Statistical methodology for assessing homology of intronic regions of genes

We consider the problem of statistically evaluating the similarity of DNA intronic regions of genes. Present algorithms are based on matching a sequence of interest with known DNA sequences in a gene bank and are designed primarily to assess homology among exonic regions of genes. Most research focuses on exonic regions because they have a clear biological significance, coding for proteins, and therefore tend to be more conserved in evolution than intronic regions. To investigate whether the intronic features of genes whose expression is highly sensitive to environmental perturbations differ from genes that have a more constant expression, a collection of oncogenes, tumor suppressor genes, and nonregulatory genes involved in energy metabolism are compared. An analysis of the features of these genes' intronic regions result in clustering by regulatory group. In addition, Billingsley's test for Markov structure (1961) suggests that 67% of the intronic regions in this collection of genes show evidence of nonrandom structure, indicating the possibility of a biological function for these regions. The result of Billingsley's test for homology is used as input to a clustering algorithm. The biological significance of this methodology lies in the identification of groups based on the intronic regions from genes of unknown function. With the advent of rapid sequencing techniques, there is a great need for statistical techniques to help identify the purpose of poorly understood portions of genes. These methods can be utilized to assess the functional group to which such a gene might possibly belong.     

Use of time and preferences for time allocation among urban,employed, married women

This study examines the relationship between employed wives' preferences for household production time, employment time, leisure, and their actual time use. A random sample of 235 employed, married women estimate their time use on an average weekday and weekend day in 13 activities and indicate their preferences for time in those activities. Hierarchical multiple regression procedures are used to examine the relationships between actual and preferred time use. Weekday employment time is not related to preferences for more or less time in household production but wives allocating more time to employment want to spend less time at that employment and more time in leisure. Weekend employment time is related to preferences for more time in leisure, child care, and other household work. Time spent performing household work is not related to preferences for more or less time in any activity except the desire for more leisure time on weekends.Ann Renigar Hiatt is Assistant Professor in the Department of Human Services, College of Education and Allied Professions at the University of North Carolina at Charlotte, Charlotte, NC 28223. Her research interests include employed women's time allocation, time pressures, and use of time management strategies. She received her Ph.D. from the University of North Carolina at Greensboro.Deborah D. Godwin is Associate Professor in the Department of Housing and Consumer Economics at the University of Georgia, Athens, GA 30602. Her research has focused on husbands' and wives' time allocation to household production, the effects of women's employment on family economic functioning, and family financial management. She received her Ph.D. from the University of North Carolina at Greensbore.     

Generalizability of Gottman and Colleagues' Affective Process Models of Couples' Relationship Outcomes

The generalizability of Gottman et al's. (1998) affective process models was examined using a community-based sample of 85 married or cohabiting couples with at-risk backgrounds. Predictive associations between affective processes assessed at about age 21 years and relationship status and satisfaction approximately 2.5 years later were examined. The major findings of Gottman et al. failed to replicate. In particular, men's rejection of their partners' influence, the lack of men's deescalation of partners' negative affect, and women's negative start up were not predictive of relationship status. Further, differences in affective processes were found when comparing discussion sessions of the men's versus the women's chosen topics. The findings suggested that the validity and utility of the affective process models need further investigation.     

Northern Crises

Abstract

Using feminist disability studies and intersectionality, this article draws upon the ongoing resource extractions in Labrador, Canada to argue for examining local communities and relationships as one way to understand gender and global social, economic and environmental crises. The article explores how crises in Labrador have been constituted and maintained around global agendas of economic and resource development, historical and current colonial practices and a limited and constrained international relations with local Indigenous nations. The lives of women and their communities in Labrador illustrate one wave of a global crisis that extinguishes diversity and connection to the land in a race to extract natural resources, maintain global military power and gain profit in the global economy. The actions over the past thirty years by NATO and the Canadian federal, provincial and municipal governments, coupled with transnational mining corporations such as Vale, have “normalized” crisis in the communities and reduced the capacity of these communities and Indigenous nations to respond to the issues arising as a result of the Muskrat Falls hydroelectric development project. Yet the women and their communities illustrate their agency and reject an analysis of them exclusively as victims. Together with researchers and activists, the women in Labrador have built a community of practice in the Feminist Northern Network.     

The shtetl in the museum: representing Jews in the eras of Stalin and Putin

This article considers the representation of the shtetl in two museum narratives devoted to Jews in Soviet and post-Soviet Russia. The first, the state-funded 1939 exhibit “The Jews in Tsarist Russia and the USSR” was organized by the Jewish Section of the State Museum of Ethnography in Leningrad and remained on display to the Soviet public until the Nazi invasion in June 1941. The second is the privately funded Jewish Museum and Tolerance Center in Moscow, which opened in 2012. Though conceived under radically different ideological and political circumstances, each exhibition conveys a significant message about the place of Jews in Soviet and post-Soviet society, respectively, and each positions the shtetl as a formative arena for Jewish civic identity vis-à-vis the Russian homeland. Across the chasm of over seventy years, these two museum projects raise strikingly similar questions about how and why cultural institutions are mobilized to define the relationship of Ashkenazi Jews and the state. In both cases, the shtetl plays a significant role in narrating this unequal relationship.     

Class voting, social change, and the left in Australia, 1943-96

The relationship between class and voting choices has been the subject of controversy in recent years, especially in connection with the apparent decline of the traditional left. This paper examines class voting in Australia, focusing on three major issues: (1) changes in the overall strength of class voting (2) realignment, or changes in the relative political positions of the classes (3) the connection between the strength of class voting and support for Labor. It finds that (1) there is a decline in 'general' class voting (2) much of this decline involves a realignment of certain middle class groups, but there is no support for the popular idea that class alignments have become more complex (3) there is no connection between the strength of class voting and Labor performance. Our results cast doubt on accounts that regard the electoral difficulties of left parties as a symptom of the decline of class.     

Parents’ economic support of young-adult children: do socioeconomic circumstances matter?

We assess how the support parents provide to young adults as they leave school and begin working is related to their family’s socioeconomic circumstances. We do this using an innovative Australian data set which merges survey and administrative data. The survey data inform us about intergenerational co-residence and financial gifts and the administrative data about the family’s welfare receipt history. We find that disadvantaged young people are more likely to be economically independent of their parents than are their more advantaged peers. This disparity is larger for financial gifts than for co-residence and increases with age. Moreover, there is a complex relationship between parental support and participation in study and work. We find no evidence, however, that a lack of parental support is the source of the socioeconomic gradient in either studying or employment. These results are important in eliminating one potential pathway through which socioeconomic disadvantage limits young people’s outcomes.