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11.
Both treatment efficacy and safety are typically the primary endpoints in Phase II, and even in some Phase III, clinical trials. Efficacy is frequently measured by time to response, death, or some other milestone event and thus is a continuous, possibly censored, outcome. Safety, however, is frequently measured on a discrete scale; in Eastern Cooperative Oncology Group clinical trial E2290, it was measured as the number of weekly rounds of chemotherapy that were tolerable to colorectal cancer patients. For the joint analysis of efficacy and safety, we propose a non-parametric, computationally simple estimator for the bivariate survival function when one time-to-event is continuous, one is discrete, and both are subject to right-censoring. The bivariate censoring times may depend on each other, but they are assumed to be independent of both event times. We derive a closed-form covariance estimator for the survivor function which allows for inference to be based on any of several possible statistics of interest. In addition, we derive its covariance with respect to calendar time of analysis, allowing for its use in sequential studies. 相似文献
12.
Denise Shelley Newnham 《思想、文化和活动》2018,25(2):138-150
An epistemological and methodological approach, The Change Laboratory, is analysed to determine which forms of distributing knowledge are apparent during cross-cultural research. Distributing knowledge is intricately related to methodological design, to researchers’ and practitioners’ life experiences and to roles of power. The article concludes that research conducted across cultures necessitates careful analysis of the power found within forms of distributing knowledge. This power is derived from a tacit belief that certain knowledge is only available to those within a given circle or that it is available to those outside a given circle without alteration. 相似文献
13.
Denise McLane-Davison 《Journal Of Human Behavior In The Social Environment》2017,27(5):474-486
ABSTRACTStanding on the hope of the initial social work course from 1914 at Morgan College, this article provides insight into the significant learning outcomes of contemporary students in advanced social work practice with urban African American families. This research introduces the conceptual framework of urban womanist social work pedagogy as an inclusive practice-informed knowledge produced through the rituals, traditions, values, culture, and resilience of historically disenfranchised communities. Urban womanist social work teaching methods honor truth telling from the ones who have lived there. Urban womanist social work affirms transformative-centered research, teaching, and scholarship produced through institutions such as historically black colleges and universities (HBCU’s). The students’ reflective narratives reveal a process of transformation, centered in the freedom standpoint, which includes recognizing the location and context of their individual and collective identity as African Americans in the profession of social work. Urban womanist social work pedagogy cumulatively equips our students with intergenerational knowledge that inform their assessment of critical issues in Baltimore’s African American communities. 相似文献
14.
The purpose of this study was to elucidate Cambodian refugees’ perceptions of immigration-related stressors and their impacts on intergenerational relations during the processes of immigration and settlement. We used narrative analysis to evoke older immigrants’ voices as they transitioned to the United States. Thirty-one Cambodian immigrants were interviewed using open-ended interview guides informed by ethnographic tenets of data collection. Participants expressed (a) changes in family structure and elder isolation and (b) intergenerational ambivalence and elder’s dependence on adult children as products of immigration-related stressors. Implications of these results for refugee and immigrant mental health research are discussed. 相似文献
15.
With the decline of public trust in corporate America, organizations must consider ways to improve their relationships with key publics. One of the best strategies to build trust is through engaging in transparent communication (Rawlins, 2009). The increase in the popularity of social media has brought both challenges and opportunities for organizational transparency. This study used multiple methods to explore whether public relations professionals believe they are using social media to communicate transparently, to investigate how social media can be used to improve transparency along with its benefits and challenges, and to identify how transparency is used in social media campaigns. 相似文献
16.
Dara Seybold Byron Calhoun Denise Burgess Tammi Lewis Kelly Gilbert Angie Casto 《Journal of social work practice in the addictions》2014,14(3):239-249
The objective of this article is not to present a scientific or systematic study, but to provide an initial framework for designing a training workshop to enhance health practitioners’ (nurses, social workers, physicians, etc.) knowledge regarding substance abuse treatment and to decrease their bias toward substance-abusing women, particularly pregnant women in rural communities. We incorporated the 4 Transdisciplinary Foundations from the Substance Abuse and Mental Health Services Administration Competencies Model, with specific competencies targeted that related to provider bias. After the conference, 52 of the 70 participants completed a questionnaire to self-assess knowledge level and confidence in skill related to substance abuse management. Participant mean scores were statistically significantly higher following the conference than 1 week prior (p < .001) in the area of “gender difference with substance abuse,” moving from an average of 2.6 to 4.5 on a 5-point Likert scale. Our conference was successful in increasing attendees’ knowledge about gender difference and substance abuse among pregnant patients. 相似文献
17.
Practice based learning in Northern Ireland is a core element of social work education and comprising 50% of the degree programme for undergraduate and postgraduate students. This article presents evidence about the perceptions of practice learning from voluntary sector/non-government organisation (NGO) placement providers and final year social work students on social work degree programmes in Northern Ireland in 2011. It draws on data from 121 respondents from189 final year students and focus group interviews with voluntary sector providers offering 16% (85) of the total placements available to students. The agencies who participated in the research study provide a total of 55 PLOs to social work students, and are therefore fairly representative in terms of voluntary sector (NGO) provision. The article locates these data in the context of practice learning pedagogy and the changes introduced by the Regional Strategy for Practice Learning Provision in Northern Ireland 2010–2015. Several themes emerged including; induction, support and guidance, practice educator/student relationship, professional identity and confidence in risk assessment and decision-making. Social work educators, placement providers and employers must be cognisant of newly qualified social workers’ needs in terms of consolidating knowledge within the formative stages of their professional development. 相似文献
18.
This article explores the contradictory results of the shift from a race‐conscious affirmative action discourse to a broader “diversity embrace” that advocates tolerance, equality, and respect for cultural differences on university campuses. Drawing on critical race theory and research on the practice of affirmative action in organizations, we argue that the diversity embrace subsumes recognition of racialized histories, social relations, and practices in favor of a “color‐blind” rhetoric that reinforces negative assumptions about the academic merit and worthiness of underrepresented minority students (URM). Our review of the status and condition of URM graduate students in sociology departments reveals that minority inclusion is part of a larger strategy that emphasizes individual and group differences rather than corrective action for past discrimination. We find that access and inclusion in graduate programs in sociology have been uneven with relatively few departments producing a majority of URM sociology doctorates. The diversity embrace obscures their continual low representation in graduate programs, fosters professionalization practices detrimental to these students, and undermines efforts to create a “critical mass” of faculty of color. Such practices constitute a racial project that preserves White privilege at the individual and institutional levels. 相似文献
19.
This paper reviews the human resource management literature on the management of workplace conflict. It suggests that workplace conflict is commonly viewed in the literature as a symptom of management failure: the notion that conflict may be intrinsic to the nature of work because employees and managers have hard‐to‐reconcile competing interests is given short‐shrift. At the same time, the paper identifies important differences in the literature, which the authors call ‘pathways’, about the best methods to manage problems at the workplace. It is argued that four contrasting pathways can be detected in the literature with regard to how organizations approach workplace conflict management practices. Each pathway is examined fully and their respective strengths and weaknesses are assessed. 相似文献
20.
Prof. Dr. Dipl.-Psych. Heidi Möller Dipl.-Psych. Katrin Oellerich Denise Elisabeth Schubert M.Sc. Dipl.-Psych. Silja Kotte 《Organisationsberatung, Supervision, Coaching》2014,21(3):313-327
This article deals with the extent to which consulting research and consulting practice are pulling in the same direction or whether the gap between them still seems insurmountable. Therefore we examine the literature on consulting research, report what kind of research coaching practitioners would consider beneficial and introduce first findings from an empirical survey in which coaching practitioners were asked about their motivation for—or against—taking part in coaching research. 相似文献