A new biogerontology lab in newcastle

The Henry Wellcome Laboratory for Biogerontology Research has opened at the University of Newcastle upon Tyne. The official opening followed the 4th European Congress of Biogerontology and was witnessed by many of its participants as well as a few special guests.     

Lipofuscin and aging: a matter of toxic waste

Lipofuscin is membrane-bound cellular waste that can be neither degraded nor ejected from the cell but can only be diluted through cell division and subsequent growth. The fate of postmitotic cells is to accumulate lipofuscin, which as an "aging pigment" has been considered a reliable biomarker for the age of cells such as neurons and, by extension, their hosts. In the aging human brain, deposits of lipofuscin are not uniformly distributed but are concentrated in specific regions of functional interest. The prevailing thought is that the major source of lipofuscin is incomplete lysosomal degradation of damaged mitochondria. Accumulating evidence suggests that lipofuscin is not benign but can impair the functioning of seemingly unrelated cellular systems, including the ubiquitin/proteasome pathway. A damaging feedback loop of lysosomal and proteasomal inhibition may occur as lipofuscin accumulates, leading to what has been appropriately named a "garbage catastrophe." Reversing this catastrophe presents a formidable challenge.     

Gambling and other risk behaviors on university campuses

To examine the prevalence of problem gambling and its relationship to other risk-taking behaviors, the authors surveyed 1,350 undergraduates at the 4 campuses of Connecticut State University (CSU) during fall 2000. On the basis of a modified version of the South Oaks Gambling Screen, a widely used screening instrument, they found that 18% of the men and 4% of the women reported that gambling had led to at least 3 negative life consequences (eg, felt guilty, gambled more than intended), commonly defined as problem gambling. Students identified as problem gamblers, compared with other students, were significantly more likely to be heavy drinkers, report negative consequences of alcohol consumption, and be regular tobacco and marijuana users. Problem gambling was related to binge eating and greater use of weight-control efforts. University athletes were also found to have significantly greater problem gambling rates than nonathletes. The majority of students gambled but experienced few of the negative consequences reported by problem gamblers.     

Training family therapists to work with children and families: a modified Delphi study

This study examined child inclusion issues and training marriage and family therapists (MFTs) to treat children. This modified Delphi study utilized a panel of experts, and gathered data through questionnaires and qualitative interviews. Panelists believe children should participate in family therapy sessions for both child and adult problems, except when parents are discussing sex or sensitive issues. Child-focused courses should emphasize developmental issues, engaging techniques, theoretical issues, play therapy theory, MFT treatment for child disorders, and specific child/family problems. Panelists suggest numerous child-focused references, but reached consensus for only one. Key therapist attributes and skills were identified. Deductive and inductive training methods and the role of supervision were highlighted. Although therapist playfulness and creativity were emphasized, few play techniques were included in the final profile.     

Perspectivities in irreducible collineation groups of projective planes,II

Collineation groups of finite projective planes are studied which do not leave invariant any point, line or triangle and contain a non-trivial perspectivity. In many instances the collineation group G can be determined, and it can be proved that the underlying projective plane contains a desarguesian subplane, whose order is related to the order of G. This can be done, because one has rather strong results about the structure of G, in particular about the first terms of a chief series of G. Projective planes are taken here as a suitable testing ground for methods, which can be used for many classes of designs to quickly find new examples and obtain some classification.     

Ubiquitin,proteasomes, and the aging brain

Ubiquitinated proteinaceous inclusions are the hallmark of many neurodegenerative diseases. Inefficient proteolysis might lead to the accumulation and ultimate deposition of potentially toxic entities as inclusions within neurons or glial cells. This hypothesis is supported by genetic evidence both from patient populations and from engineered mutations in genes that encode ubiquitin/proteasome components in mice. The appearance of similar inclusions in the brains of elderly individuals of normal and subclinical conditions begs the question of whether there is a general age-related decline in the ability of the ubiquitin/proteasome pathway (UPP) to recognize and eliminate abnormal proteins, and whether such a decline would be reflected by changes in the abundance or activity of some or all components of the UPP. Here we describe alterations in the aging mammalian brain that correlate with a decline in the function of the UPP and review the evidence for age-related changes in specific UPP components. These alterations are discussed within the context of prevalent theories of aging.     

Extending the family of Bayesian bootstraps and exchangeable urn schemes

A Bayesian bootstrap for a finite population with censored observations is introduced. It is shown to reduce to the finite population Bayesian bootstrap if there is no censoring and to reduce to the censored data Bayesian bootstrap for a large population. A class of general urn schemes for simulating exchangeable sequences of variables is introduced which is connected to the bootstrap method.     

Lived Experience and Interpretation in Narrative Theory: Experiences of Living with HIV/AIDS

Narrative analysis builds on the strengths of qualitative research by examining the construction of meaning and symbolic systems in a framework that is explicitly temporal and that links research in the humanities with that in the social sciences. Qualitative methodologies often assume reported data accurately reflects the realities of lived experience. On the other hand some research drawing on cultural studies argues that the facts of a person's life are irrelevant. This paper argues for a middle way based on narrative theory that explores the interaction of objective events and their subjective interpretation. Further, narrative analysis enables exploration of the temporal structure of people's experiences focusing on both how a person's memories of the past and anticipations of the future influence their understanding and actions in the present. These points are developed drawing on the theory and methodology of both Symbolic Interactionism and Paul Ricoeur's Hermeneutics. The experiences of people living with HIV/AIDS are used to illustrate and explicate the usefulness of narrative analysis.     

Nonmanipulable voting schemes when participants' interests are partially decomposable

Recent papers by Barberá and Peleg and by Zhou have established that the Gibbard-Satterthwaite Theorem remains valid when individuals are restricted to reporting only reasonable preferences. We present a theorem that covers situations in which, as in Barberá-and-Peleg and Zhou, preferences may be restricted to reasonable ones, but in which, additionally, it may be known in advance that some dimensions of the social decision do not affect all the participants — i.e., in which the social decisions are partially decomposable into decisions that affect only subsets of the participants. As in the previous theorems, the conclusion of this new theorem is that nonmanipulable voting schemes must be dictatorial.An early version of this paper was delevered at the 1989 NBER-NSF Conference on Decentralization at Cal Tech; comments by the conference participants are appreciated, as are comments by James Schmitz.