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621.
Mike Campbell 《Significance》2005,2(3):116-118
It has recently been suggested 1 that many clinical trials should have a data monitoring and ethics committee, and that on this committee should be a statistician. Such committees are attached to individual trials and are distinct from local ethics committees, which are not required to have a statistician and are not concerned solely with trials. Given the plethora of trials, there will be increasing demand for statisticians to sit on these committees. Although it is both an honour and a privilege, Mike Campbell warns that membership should not be undertaken lightly. 相似文献
622.
Disciplinary alternative schools have a reputation as gateways to the juvenile and criminal justice systems. The authors conducted an evaluation of an intervention (Strategies for Success) designed to divert seventh-, eighth-, and ninth-grade alternative school students from this gateway. They used propensity score matching and a multivariate random effects model to estimate program impacts and found that the program not only increased attendance rates, at least in the short term, but also increased the likelihood of reassignment to alternative schools. The discussion focuses on possible reasons and solutions for high rates of return to alternative school and for the erosion of program effects. 相似文献
623.
Elaine Chan 《Social indicators research》2014,119(2):803-821
This article aims to ascertain whether organizational life and informal connections, which made up part of Putnam’s (Bowling alone: the collapse and revival of American community. Simon & Schuster, New York, 2000) Social Capital Index, have separate effects on social cohesion. Postulating that informal gatherings with family and friends might be a functional alternative to associational life, we employed multiple regression analysis to test the hypothesis. The analysis was based on a 2011 territory-wide door-to-door survey in Hong Kong. Controlling for the effects of demographic variables including gender, age, educational level, and employment status, it was found that formal participation in organizations contributed significantly to the explanation in five of the eight subindexes of social cohesion. In contrast, informal connections contributed significantly only to one subindex. The pattern persisted when attitudinal variables such as life satisfaction, social support, and perceived social class were added to the regression analysis. In short, our analysis demonstrated that participation in formal organizations fosters various aspects of social cohesion, and that this effect cannot be replaced by informal gatherings with family and friends. 相似文献
624.
Young-Oak Wells Elaine Dietsch 《Women and birth : journal of the Australian College of Midwives》2014,27(4):e1-e6
BackgroundThe percentage of overseas-born mothers giving birth in Australia has increased to 31.5% in 2012 and Indian women represent 10% (the highest proportion). It is important for midwives in Australia to be aware of the childbearing traditions of Indian women and how these influence Indian women birthing in Australia.AimTo explore childbearing practices in India and Indian women's experience of giving birth abroad; and to discuss the relevant findings for midwives working with Indian women in Australia.MethodAn integrative literature review was employed. 32 items, including 18 original research articles were thematically reviewed to identify commonly occurring themes relating to Indian women's childbearing traditions.FindingsFive themes relating to traditional childbearing practices of women birthing in India were identified. These themes included diversity and disparity; social context of childbirth and marriage; diet based on Ayurveda; pollution theory and confinement; and finally, rituals and customs.ConclusionIndian women giving birth abroad and by implication in Australia experience a transition to motherhood in a new culture. While adjusting to motherhood, they are also negotiating between their old and new cultural identities. To provide culturally safe care, it is essential that midwives reflect on their own culture while exploring what traditions are important for Indian women. 相似文献
625.
This article considers a discrete-time Markov chain for modeling transition probabilities when multiple successive observations are missing at random between two observed outcomes using three methods: a na\"?ve analog of complete-case analysis using the observed one-step transitions alone, a non data-augmentation method (NL) by solving nonlinear equations, and a data-augmentation method, the Expectation-Maximization (EM) algorithm. The explicit form of the conditional log-likelihood given the observed information as required by the E step is provided, and the iterative formula in the M step is expressed in a closed form. An empirical study was performed to examine the accuracy and precision of the estimates obtained in the three methods under ignorable missing mechanisms of missing completely at random and missing at random. A dataset from the mental health arena was used for illustration. It was found that both data-augmentation and nonaugmentation methods provide accurate and precise point estimation, and that the na\"?ve method resulted in estimates of the transition probabilities with similar bias but larger MSE. The NL method and the EM algorithm in general provide similar results whereas the latter provides conditional expected row margins leading to smaller standard errors. 相似文献
626.
Claire Watkins Xin Huang Nicholas Latimer Yiyun Tang Elaine J. Wright 《Pharmaceutical statistics》2013,12(6):348-357
In parallel group trials, long‐term efficacy endpoints may be affected if some patients switch or cross over to the alternative treatment arm prior to the event. In oncology trials, switch to the experimental treatment can occur in the control arm following disease progression and potentially impact overall survival. It may be a clinically relevant question to estimate the efficacy that would have been observed if no patients had switched, for example, to estimate ‘real‐life’ clinical effectiveness for a health technology assessment. Several commonly used statistical methods are available that try to adjust time‐to‐event data to account for treatment switching, ranging from naive exclusion and censoring approaches to more complex inverse probability of censoring weighting and rank‐preserving structural failure time models. These are described, along with their key assumptions, strengths, and limitations. Best practice guidance is provided for both trial design and analysis when switching is anticipated. Available statistical software is summarized, and examples are provided of the application of these methods in health technology assessments of oncology trials. Key considerations include having a clearly articulated rationale and research question and a well‐designed trial with sufficient good quality data collection to enable robust statistical analysis. No analysis method is universally suitable in all situations, and each makes strong untestable assumptions. There is a need for further research into new or improved techniques. This information should aid statisticians and their colleagues to improve the design and analysis of clinical trials where treatment switch is anticipated. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
627.
628.
The literature on gender differences in orientations to work among Protestant clergy has been mixed, but generally points to the hypothesis that female clergy hold fewer career and professional work values than their male counterparts. This expectation flies in the face, however, of other more general population studies that show women and men hold similar work values and orientations to work. Using a national sample of clergy from two Protestant denominations, we test for gender differences in these values and orientations. Consistent with the general population findings, female clergy have professional values and orientations that are just as strong, if not stronger than those of male clergy. 相似文献
629.
A common problem with medical surveillance programs using biomarkers is determining the optimal frequency of testing to minimize adverse health effects and cost. In the case of beryllium-exposed workers, frequency of testing for beryllium sensitization may be especially important. Recent studies indicate a lack of dose response for beryllium sensitization, but do support a dose response for the development of chronic beryllium disease (CBD). Though unproven, this implies that early identification of sensitization and immediate removal from exposure may reduce development of CBD. A model is proposed to project the optimal frequency of sensitization testing using the current beryllium lymphocyte proliferation test (BeLPT) to minimize disease-related costs, assuming that a positive BeLPT will precede CBD. Conversion rates for cumulative exposure to disease development were adapted from the literature and used with testing costs and cost of disease estimates in the model. The model was run assuming several test frequency regimes. Results support the use of periodic testing in line with the annual schedule proposed in the Final Chronic Beryllium Disease Prevention Program Rule (1999) following initial testing within three months of first beryllium exposure. The financial and health benefits of reducing the time from exposure to detection of early disease was also explored with the model and demonstrated as a highly desirable characteristic for an alternative test or improved BeLPT. Limitations of the approach are discussed as well as options for adapting this biomarker optimization methodology to consider biomarkers of other exposure-associated diseases. 相似文献
630.
Donald K. Fromme William E. Jaynes Deborah K. Taylor Elaine G. Hanold Jennifer Daniell J. Richard Rountree Marie L. Fromme 《Journal of Nonverbal Behavior》1989,13(1):3-14
A measure of comfort with touching was found to predict whether or not subjects would volunteer to participate in an experiment involving hugging strangers of both sexes and also to predict levels of personal space. Among those volunteering to give hugs, subjects reporting greater comfort with touch rated those hugs more positively, but this seemed to reflect a readiness to interpret touch positively rather than any clear differences in the nature of the hug actually given. Earlier findings that women report greater comfort with touch than do men were replicated. It was found that reported touch comfort was directly related to such constructs as satisfaction with life, with oneself, and with one's childhood, as well as to self-confidence, assertiveness, socially acceptable self-presentation, and active rather than passive modes of coping with problems. Touch comfort was inversely related to expressed concerns with touches which might reflect status differentials, homosexuality, or negative affective states. It was concluded that the touch comfort construct reflects the degree of one's openness to expressing intimate behavior, the degree to which one adopts an active, rather than passive, interpersonal style, and the degree to which one's social relationships are satisfactory. 相似文献