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101.
102.
Fabio Lopez Chiara Di Bartolo Tommaso Piazza Antonino Passannanti Jörg C. Gerlach Bruno Gridelli Fabio Triolo 《Risk analysis》2010,30(12):1857-1871
International regulatory authorities view risk management as an essential production need for the development of innovative, somatic cell‐based therapies in regenerative medicine. The available risk management guidelines, however, provide little guidance on specific risk analysis approaches and procedures applicable in clinical cell therapy manufacturing. This raises a number of problems. Cell manufacturing is a poorly automated process, prone to operator‐introduced variations, and affected by heterogeneity of the processed organs/tissues and lot‐dependent variability of reagent (e.g., collagenase) efficiency. In this study, the principal challenges faced in a cell‐based product manufacturing context (i.e., high dependence on human intervention and absence of reference standards for acceptable risk levels) are identified and addressed, and a risk management model approach applicable to manufacturing of cells for clinical use is described for the first time. The use of the heuristic and pseudo‐quantitative failure mode and effect analysis/failure mode and critical effect analysis risk analysis technique associated with direct estimation of severity, occurrence, and detection is, in this specific context, as effective as, but more efficient than, the analytic hierarchy process. Moreover, a severity/occurrence matrix and Pareto analysis can be successfully adopted to identify priority failure modes on which to act to mitigate risks. The application of this approach to clinical cell therapy manufacturing in regenerative medicine is also discussed. 相似文献
103.
Using insurance data, medically impairing injuries sustained by 111 firefighters were analyzed. The injury incidence per year among full-time working firefighters was 39 per 10 000, and among part-time working firefighters 6 per 10 000. More than half (51%) were injured during fitness training, 14% during job training, and 13% during emergency response, while 4% were injured in traffic crashes and 18% in other injury events. Soccer and floorball caused 82% of all fitness injuries, of which more than half were meniscal or sprain injuries of knees or ankles. None of those injured during emergency response suffered from burn injuries, however during job training 4 sustained burns. Less injurious fitness training and practice activities could greatly reduce impairing injuries among firefighters and consequently reduce economical losses and disability. 相似文献
104.
105.
Michael Bölker 《Poiesis & praxis》2004,3(1-2):73-82
Genetic variability and diversity are the result of a mutation-selection balance that acts permanently within and between species. The presence of deleterious mutations is a necessary consequence of this process and thus “the price paid by a species for its capacity for further evolution” (Haldane 1937, Am Nat 71:337–349). Recent estimations of mutation rate in the human lineage has revived the debate as to whether the high number of deleterious mutations poses a severe problem for the future of mankind. Theoretical considerations allow a scenario in which the survival of the human race is maintained by truncation selection of deleterious mutations that removes as many mutations as appear anew in every generation. In this case our genetic burden is carried by those individuals that suffer a genetic death resulting from random distribution of deleterious alleles. Nevertheless, one has to ask whether the mutation rate may set absolute limits on the complexity of a species. 相似文献
106.
It may be difficult or impossible to make a reliable empirical investigation of an unknown network of interpersonal choices or contacts if these are in some respect sensitive for the individuals involved. We consider how choice data given anonymously can be used to reveal various features of the network. Using tools from statistical decision theory and information theory we can determine risks and capacities of disclosing choice data, the graph structure of choice data and its numbers of loops and mutuals. We give some general results, illustrate the combinatorial complexity of the problem and comment upon the computational difficulties. 相似文献
107.
A projective (2n,n,λ,1)-design is a set of n element subsets (called blocks) of a 2n-element set V having the properties that each element of V is a member of λ blocks and every two blocks have a non-empty intersection. This paper establishes existence and non-existence results for various projective (2n,n,λ,1)-designs and their subdesigns. 相似文献
108.
109.
The costs of hospitals. Developments of the German hospital sector evaluated in the case of Berlin This article illustrates the development of the German hospital sector evaluated in the case of the capital Berlin. Due to the difficult economic situation of the hospital sector after the reunification major reforms became unavoidable. Especially a reduction of the average days of stay per case created overcapacities of personell. But all the reforms which have been taken during the last years had to consider the major role of the hospital sector for the labour market of the city. On the one hand the article shows, that the reforms of the nineties have been successful also with regard to the important role for the labour market. On the other hand the restructuring of the hospital sector is not finished yet, there is still a need for further reforms. 相似文献
110.
Martin Körner 《Zeitschrift für Betriebswirtschaft》2007,77(11):1111-1134
Zusammenfassung Der Beitrag erkl?rt einerseits die Notwendigkeit eines durch Gesetz geregelten Verfahrens zur Insolvenzabwicklung mittels
betriebswirtschaftlicher Grundlagentheorien. Andererseits werden dieselben Grundlagentheorien genutzt, um die unterschiedlichen
sich ver?ndernden Machtstrukturen, die oft gegens?tzlichen Interessen von Stakeholdern, die Kosten des Insolvenzprozesses
sowie deren Dynamik im Rahmen des vierphasigen Insolvenzprozesses (vor Insolvenzanmeldung, nach Antragstellung, nach Er?ffnung,
nach Abschluss des Verfahrens) eines Not leidenden Unternehmens besser veranschaulichen zu k?nnen. Der besondere Schwerpunkt
wird hierbei auf das Verfahren in Eigenverwaltung, das hei?t mit eigenem Management, gelegt.
The bankruptcy process and the self-administration in the bankruptcy proceedings
Summary This article explains on one hand the necessity of a legally fixed process for the bankruptcy proceedings with basic economic theories. On the other hand, the same theories are used to demonstrate the changing power structures, the often different interests of stakeholders, the costs of the bankruptcy proceedings as well as its dynamics during the four bankruptcy phases (before the filing, after the filing, after opening and after closing) of the bankruptcy process. The focus of this article lies hereby on bankruptcy proceedings in self-administration which means that the management stays on duty.
Dr. Martin K?rner ist promovierter Diplom- und Bankkaufmann und leitet die Abteilung Strategic Advisory bei einem führenden europ?ischen IT- und Telekommunikationsunternehmen. Seine Forschungsgebiete umfassen strategische Fragestellungen, Kapitalmarktthemen, das Outsorcing sowie das Krisen- und Insolvenzmanagement. 相似文献