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41.
This article is devoted to the construction and asymptotic study of adaptive, group‐sequential, covariate‐adjusted randomized clinical trials analysed through the prism of the semiparametric methodology of targeted maximum likelihood estimation. We show how to build, as the data accrue group‐sequentially, a sampling design that targets a user‐supplied optimal covariate‐adjusted design. We also show how to carry out sound statistical inference based on such an adaptive sampling scheme (therefore extending some results known in the independent and identically distributed setting only so far), and how group‐sequential testing applies on top of it. The procedure is robust (i.e. consistent even if the working model is mis‐specified). A simulation study confirms the theoretical results and validates the conjecture that the procedure may also be efficient. 相似文献
42.
We derive an identity for nonparametric maximum likelihood estimators (NPMLE) and regularized MLEs in censored data models which expresses the standardized maximum likelihood estimator in terms of the standardized empirical process. This identity provides an effective starting point in proving both consistency and efficiency of NPMLE and regularized MLE. The identity and corresponding method for proving efficiency is illustrated for the NPMLE in the univariate right-censored data model, the regularized MLE in the current status data model and for an implicit NPMLE based on a mixture of right-censored and current status data. Furthermore, a general algorithm for estimation of the limiting variance of the NPMLE is provided. This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
43.
Ellen Fladger 《Serials Review》2008,34(1):77-78
44.
Blythe Durbin Sandrine DudoitMark J. van der Laan 《Journal of statistical planning and inference》2008
Neural networks are a popular machine learning tool, particularly in applications such as protein structure prediction; however, overfitting can pose an obstacle to their effective use. Due to the large number of parameters in a typical neural network, one may obtain a network fit that perfectly predicts the learning data, yet fails to generalize to other data sets. One way of reducing the size of the parmeter space is to alter the network topology so that some edges are removed; however it is often not immediately apparent which edges should be eliminated. We propose a data-adaptive method of selecting an optimal network architecture using a deletion/substitution/addition algorithm. Results of this approach to classification are presented on simulated data and the breast cancer data of Wolberg and Mangasarian [1990. Multisurface method of pattern separation for medical diagnosis applied to breast cytology. Proc. Nat. Acad. Sci. 87, 9193–9196]. 相似文献
45.
Mohajer Hameed Jennifer McIntosh Siân McLean An Vuong Ellen Welsh Brendan O'Hanlon 《Australian and New Zealand Journal of Family Therapy》2023,44(2):201-213
Internationally, while the interdisciplinary field of family therapy and systemic practices is well established and evidence for therapeutic impact is advanced, evaluation of training and measurement of its impact lags behind. This paper addresses this gap, utilising a single case study at the Bouverie Centre, the largest family therapy and workforce development service in Australia. We describe (a) the scope of workforce training and implementation at the Centre, (b) the development of our training research and evaluation framework, and (c) standardised data collection methodology, including a pre-post training reflective survey. Collectively, this work comprises our current evaluation framework through which we will subsequently examine training impact. Future research and practice recommendations are offered to address challenges to workforce training evaluation and progress efficacy of family therapy training. 相似文献
46.
Abstract There is a growing emphasis in the social work literature that social work's overall mission should be that of social justice and that mental health be relegated as outside of social work's realm. This paper draws upon a constructionist and narrative perspective in developing a general formulation of clinical social work to bridge the gap between social justice and mental health. 相似文献
47.
48.
Household headship historically has been equated with being the main economic provider of the household, a position usually occupied by men. This paper uses a change in the United States Census definition of household headship to examine whether headship for married women is associated with being the primary breadwinner in a marriage versus other non-economic explanations. According to microdata from the 1990 United States Census, women who are the main income providers in a marriage are much more likely to be household heads than women in co-provider marriages. There also is support for an egalitarian ideology explanation; that is, when both spouses are highly educated, the wife is more likely than the husband to be household head net of her relative economic independence in that marriage. Yet the force of convention remains strong given the low prevalence of headship among married women. The new census definition was meant partly to reflect the changing economic status of women. However, the reality is that conventional gender behaviors persist in household headship. 相似文献
49.
Culture and Co‐residence: An Exploration of Variation in Home‐Returning among Canadian Young Adults*
Barbara A. Mitchell Andrew V. Wister Ellen M. Gee 《Revue canadienne de sociologie》2000,37(2):197-222
Cet article s'inscrit dans la lignée des études sur les dimensions culturelles de la cohabitation entre générations en examinant de près le comportement des jeunes adultes canadiens qui retournent vivre chez leurs parents. Nous explorons les rapports mutuels entre la famille et la diversité culturelle, entre le capital financier et le capital social, et entre le rythme et les mécanismes de transitions précoces qui se manifestent au cours d'une vie. Les modéles de hasards proportionnels sont appliqués à un sous‐échantillon de 2 549 jeunes adultes, àgés de 19 á 34 ans, en tenant compte des données de l'Enquete sociale générale, cycle 10, de 1995. L'une des principales conclusions tirées ici indique que les jeunes qui sont de langue maternelle anglaise sont beaucoup plus susceptibles de retourner chez leurs parents après un premier départ que ceux dont la langue maternelle est le français ou une autre langue. Les autres variables qui entrent en jeu sont le niveau d'education du père, le nombre de frères et de soeurs, le sexe, l'âge au moment du depart de la maison et la raison de ce départ. L'article aborde aussi les questions des responsabilités et des rôles des parents autour de la cinquantaine, et de la socialisation au sein de la famille au cours de la vie. This article offers a focussed examination of variation in home‐returning behaviour among Canadian young adults. Framed within the life course perspective, we explore the interrelationships among family and cultural diversity, financial and social capital, and the timing and pathways of early transitions. Proportional hazards analyses are performed on a subsample of 2,549 young adults aged 19–34, using data from the 1995 General Social Survey, Cycle 10. A major finding is that those whose mother tongue is English are significantly more likely to return to the parental home than those with French or “other” mother tongues. Other variables include: father's education, number of siblings, gender, age at home‐leaving, and initial reason for home‐leaving. Implications for midlife parental roles and responsibilities, and for family socialization are discussed. 相似文献
50.
Ellen T. Luepker 《Clinical Social Work Journal》2010,38(2):183-192
While the literature reports therapeutic benefits of life review in the elderly, systematic involvement of family members and extensive use of video recording are uncommon. Outcomes of videotaped life reviews with 30 individuals in the general population, conducted in collaboration with family members, are described. Mutually enhanced sense of self and self-esteem were observed. Interviewees felt less fearful of traumatic events after reviewing them in the context of their entire lives. For family members afraid to ask their parents directly about painful events, the camera created safe transitional space and opportunity for more genuine connection. Using examples from popular media and the author’s videotaped work, this paper will define life review, describe the heightened need for life review in the latter stage of life, the value of systematically involving family members, and implications for including life review methods in psychotherapy. 相似文献