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61.
An objective of randomized placebo-controlled preventive HIV vaccine efficacy (VE) trials is to assess the relationship between vaccine effects to prevent HIV acquisition and continuous genetic distances of the exposing HIVs to multiple HIV strains represented in the vaccine. The set of genetic distances, only observed in failures, is collectively termed the ‘mark.’ The objective has motivated a recent study of a multivariate mark-specific hazard ratio model in the competing risks failure time analysis framework. Marks of interest, however, are commonly subject to substantial missingness, largely due to rapid post-acquisition viral evolution. In this article, we investigate the mark-specific hazard ratio model with missing multivariate marks and develop two inferential procedures based on (i) inverse probability weighting (IPW) of the complete cases, and (ii) augmentation of the IPW estimating functions by leveraging auxiliary data predictive of the mark. Asymptotic properties and finite-sample performance of the inferential procedures are presented. This research also provides general inferential methods for semiparametric density ratio/biased sampling models with missing data. We apply the developed procedures to data from the HVTN 502 ‘Step’ HIV VE trial. 相似文献
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In this paper we explore the phenomenon of Chinese counterfeits smuggled into Mexico, the world's fourth largest counterfeit market, particularly highlighting the role played by Chinese transnational crime in the production and financing of these illegal exports and the role of the Korean diaspora in the distribution of Chinese counterfeits within Mexico. Based on this case study and the extant literature, we suggest propositions concerning diaspora criminal enterprises and diaspora participants in informal markets that amend current theory concerning two streams of literature — diaspora homeland investment and trade facilitation by diasporas. 相似文献
64.
Julia E. Janes Bonny Ibhawoh Narda Razack Nathan Gilbert 《Journal of Progressive Human Services》2014,25(1):50-69
The Assets Coming Together for Youth project conducted a critical discourse analysis of mainstream media depictions of Jane-Finch to better understand the discursive strategies used to constitute urban youth. Although a substantive body of literature investigates the negative discourses, little analysis interrogates the nominally positive discourses deployed by mainstream media. The findings suggest that the sociopolitical significance of these nominally positive discourses may go uncontested and pose a challenge to communities advocating for policies to support urban youth development. These discourses are examined using governmentality theory to reveal how racialized narratives of individual triumph re/produce troubled communities. 相似文献
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Computational sociology models social phenomena using the concepts of emergence and downward causation. However, the theoretical status of these concepts is ambiguous; they suppose too much ontology and are invoked by two opposed sociological interpretations of social reality: the individualistic and the holistic. This paper aims to clarify those concepts and argue in favour of their heuristic value for social simulation. It does so by proposing a link between the concept of emergence and Luhmann's theory of communication. For Luhmann, society emerges from the bottom‐up as communication and he describes the process by which society limits the possible selections of individuals as downward causation. It is argued that this theory is well positioned to overcome some epistemological drawbacks in computational sociology. 相似文献
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Kate Woodthorpe 《Sociology Compass》2010,4(5):283-294
Abundant in books, on television, in film, on the internet, and in newspapers and magazines, in the twenty-first century death is hugely accessible. Within recent years, sociologists have responded to this visibility by examining death in the media, including its role and status in popular culture and ‘public mourning’, seen for example following the death of Diana, Princess of Wales in 1997. This article considers a third strand of death in the media that requires sociological attention: public dying. Drawing on the extensive media coverage of reality TV personality Jade Goody’s dying and subsequent death in early 2009, the article examines the way in which Goody’s dying illustrated how it can be commodified. 相似文献
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