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81.
Exact calculation of power and sample size in bioequivalence studies using two one‐sided tests 下载免费PDF全文
The number of subjects in a pharmacokinetic two‐period two‐treatment crossover bioequivalence study is typically small, most often less than 60. The most common approach to testing for bioequivalence is the two one‐sided tests procedure. No explicit mathematical formula for the power function in the context of the two one‐sided tests procedure exists in the statistical literature, although the exact power based on Owen's special case of bivariate noncentral t‐distribution has been tabulated and graphed. Several approximations have previously been published for the probability of rejection in the two one‐sided tests procedure for crossover bioequivalence studies. These approximations and associated sample size formulas are reviewed in this article and compared for various parameter combinations with exact power formulas derived here, which are computed analytically as univariate integrals and which have been validated by Monte Carlo simulations. The exact formulas for power and sample size are shown to improve markedly in realistic parameter settings over the previous approximations. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
82.
Letter to the editor by the authors of Exact Calculation of Power and Sample Size in Bioequivalence Studies Using Two One‐sided Tests,Pharmaceutical Statistics,DOI: 10.1002/pst.1666 下载免费PDF全文
This article reflects the views of the authors and should not be construed to be those of the US Food and Drug Administration. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
83.
Molly Tovar David A. Patterson Silver Wolf Julia Stevenson 《Journal of social work in disability & rehabilitation》2015,14(3-4):163-175
American Indians and Alaska Natives (AI/AN) have a long tradition of military service, allying with Western forces in North America since the 1700s. It is hardly surprising, therefore, that AI/AN veterans experience higher rates of overall disability and service-related disability than veterans of other races and ethnicities. It is not clear, however, that AI/AN veterans with disabilities are receiving effective, culturally informed rehabilitation services. This article examines the incidence of disability among contemporary AI/AN veterans, considers barriers to effective treatment, and points out model programs tailored to the particular needs of this population, with attention to the historical and cultural context of AI/AN military service. 相似文献
84.
85.
Evidence-based standards are becoming increasingly influential in frontline services connected to labor market inclusion of vulnerable citizens. To increase our understanding of standardization in such public service delivery, this study draws on interviews and ethnographic fieldwork from two frontline offices in the Norwegian Labour and Welfare Administration (2017–2018) that use the evidence-based Individual Placement and Support (IPS) standard. Adopting a theoretical perspective of organizational practices, the study highlights two distinct approaches to practicing IPS in the frontline organizations: as a “practice shift” in one organization (i.e., creating and legitimizing radically new service practices involving closer collaboration with employers) and as a “practice revival” in the other (i.e., reinstating more traditional service practices involving a holistic client orientation). Each approach relates to a specific constellation of recruitment practices, dynamics between frontline supervisors and staff, and team integration. The study contributes to the literature in two ways. First, it shows the underlying flexibility embedded in standardization and how standards may be implemented and adapted in ways that may either promote more radical change or revive traditional practices. Second, it nuances positions in the literature on the impact of standards on professional service work. On this basis, the study suggests broadening the attention in research on evidence-based standards in public service delivery from discussions of “what works” to understanding the broader organizational dynamics involved in “making it work.” 相似文献
86.
Journal of Risk and Uncertainty - We analyze the impact of risk aversion and ambiguity aversion on the competing demands for annuities and bequeathable savings using a lifecycle recursive utility... 相似文献
87.
Objectives. We examine voter turnout of inner‐city African‐American mothers, many of whom are single parents and endure long‐term, economic hardship. Previous research suggests that income is a more important factor among these groups than in the general population. We seek to understand the interplay of family structure, income, and voter turnout. Methods. We explore these ideas using panel data on 754 mothers living in Chicago and interviewed as part of the 1967–1976 Woodlawn Community Study. Results. We find that marital status has no effect when women are younger but over time single parents' turnout falls behind that of married parents. This is primarily due to factors related to income and income change. Conclusions. Single mothers have lower rates of participation and, given the high rates of single parenthood in segregated inner‐city neighborhoods, this substantially diminishes the political voice of the nation's poor, contributing to class bias in the electorate. 相似文献
88.
The phenomenon of cognitive enhancement is attracting attention in bioethics literature and beyond, in public policy. In response, three bodies--the British Medical Association (BMA); the Commission de l'éthique de la Science et de la technologie (CEST) du Québec; the American Academy of Neurology (AAN)--have produced reports and guidance on this topic. To gain insights into different public policy approaches, rationales, and recommendations on the topic, we analyzed these reports in depth. We found convergence on the definition (with the exception of the CEST) of cognitive enhancement. However, we noted a lack of critical reflection with respect to the underlying rationale for developing these reports, i.e., that cognitive enhancement practices are rampant and represent major social changes. As it currently stands, cognitive enhancement is constituted in a way that challenges the creation of coherent and effective policy recommendations. However, policy makers should not simply wait for definitional consensus and hope that on balance the benefits turn out to be greater than the risks. Some components of cognitive enhancement could be reduced down to clearly identified policy targets to be further examined. Then, if appropriate, policy should be created that is, amongst other criteria, beneficial to the majority of the population. 相似文献
89.
Eric M. Cave 《Theory and Decision》1996,41(3):229-256
Let us say that an individual possesses aprincipled preference if she prefers satisfying her preferences without violating the principles of justice governing her community to satisfying her preferences by violating these principles. Although living among possessors of principled preferences benefits individuals, maintaining such a preference is individually costly. Further, individuals can benefit from others possessing principled preferences without themselves possessing one. In this paper, I argue that occupying a choice situation which mirrors key aspects of our own situation, maximizing rationality requires individuals to develop and maintain principled preferences.To establish that maintaining a principled preference is individually rational for the occupants of such a choice situation, I define a range of individual strategies for them, model their choice of individual strategies as a game, and argue that this game involves an equilibrium in which all of its participants would choose to develop and maintain a principled preference. 相似文献
90.
Scientists study seasonality in order to understand the effect of environmental, biological, and social factors on demographic events. Poor data quality can also affect seasonal variation in mortality and fertility statistics. The influence of error on seasonal data becomes crucial as researchers analyze timing and spacing of events in time-series analyses. In this study we examine the reported number of births by month in the Soviet Union for 1950, 1955, and 1958–85. The lowest number of births has typically occurred in December, and the highest in January. This seasonal pattern is not consistent with any plausible biological or behavioural explanation. It is probably an artifact of attributing births that actually occurred during the preceding December or earlier, to January. This implies that Soviet statistical practice has not followed the stated policy of attributing births to the period (day, month, year) in which they occur. A substantial reduction between the 1950s and 1985 in the December-January peak in reported births implies marked improvement in Soviet vital registration statistics. The Soviet case shows that characteristics of the registration system can impart a particular seasonal pattern to demographic data. It also shows that officially prescribed procedures are not always followed in data generation, even in centrally planned economies. Researchers should carefully examine the quality of seasonal data before concluding that the data reflect real variations in demographic behaviour. 相似文献