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71.

Much scholarship on boundary-making focuses on dyadic relationships between “us” and “them.” Yet the presence of multiple categories within societies allows for complex interactions among more than two potentially relevant groups. To capture this phenomenon and its dynamics better, we develop the concept of leveraging: the strategic manipulation of social distance among three or more constructed groups for political gain. The use of one group as a lever against another may involve stigmatizing or elevating categories of people along boundaries of race, ethnicity, national origin, religion, gender, class, sexual orientation, or other salient social markers. We theorize these processes and identify the motivations of the initiators of leveraging as well as the range of possible responses to it. We use a pair of empirical case studies drawn from contemporary Europe and additional examples from other settings to demonstrate the relevance of the concept. Conceptualizing leveraging both improves our scholarly understanding of group-making processes and offers political actors tools for interpreting and responding to a common set of strategic practices.

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In oncology/hematology early phase clinical trials, efficacies were often observed in terms of response rate, depth, timing, and duration. However, the true clinical benefits that eventually support registrational purpose are progression-free survival (PFS) and/or overall survival (OS), the follow-up of which are typically not long enough in early phase trials. This gap imposes challenges in strategies for late phase drug development. In this article, we tackle the question by leveraging published study to establish a quantitative link between early efficacy outcomes and late phase efficacy endpoints. We used solid tumor cancer as disease model. We modeled the disease course of a RECISTv1.1 assessed solid tumor with a continuous Markov chain (CMC) model. We parameterize the transition intensity matrix of a CMC model based on published aggregate-level summary statistics, and then simulate subject-level time-to-event data. The simulated data is shown to have good approximation to published studies. PFS and/or OS could be predicted with the transition intensity matrix modified given clinical knowledge to reflect various assumptions on response rate, depth, timing, and duration. The authors have built a R shiny application named PubPredict, the tool implements the algorithm described above and allows customized features including multiple response levels, treatment crossover and varying follow-up duration. This toolset has been applied to advise phase 3 trial design when only early efficacy data are available from phase 1 or 2 studies.  相似文献   
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The present study examined what kinds of patterns of task‐values adolescents show, and whether these patterns predict their educational and occupational expectations and school track. Six hundred and fourteen adolescents were examined twice before their transition to secondary education and once thereafter. The clustering‐by‐cases analyses identified 6 groups: (1) those who placed a high value on all school subjects, (2) those who did not value any of the subjects, (3) those who valued Finnish and social sciences, (4) those who valued in particular practical and art subjects, (5) those who valued only practical and art subjects, and (6) those who especially valued mathematics and science. The patterns of task‐values also predicted adolescents' occupational and educational expectations.  相似文献   
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How do global issue constructions serve as resources for actors engaged in domestic political contention, and what does the appropriation of global ideas by domestic actors imply about the spread of global culture? To contribute to knowledge about conflict‐based diffusion of global ideas, we examine the histories of global constructions of indigenous rights and national debates about indigenous rights in Fiji and Tanzania. While global models of indigenous rights emphasize self‐determination for nondominant, culturally distinct groups at risk from the nation‐state, advocates for indigenization policies in Fiji and Tanzania have argued for state policies to entrench political and economic rights for majority or near‐majority groups that were well integrated into the nation‐state. Although transnationally connected indigenous rights organizations have a greater presence in Tanzania than in Fiji, actors in Fiji remain more engaged with changes in international indigenous rights discourse than their counterparts in Tanzania. This difference reflects variations in the leverage global culture offered in the two cases because of its externality to national political debates. In Fiji, actors appropriated global culture as a means to internationalize a domestic dispute, while in Tanzania the impetus for indigenization came from global economic pressures. Our findings imply that conflict‐based diffusion concentrates agency with respect to the use of global legal discourses in domestic actors rather than the globally connected actors and experts who carry global culture in consensus‐based diffusion.  相似文献   
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This article scrutinizes the widely held belief that British and French colonial models have influenced each countrys immigrant integration structures. It assesses the core assumptions underlying the argument: that British colonial and integration policies have relied on indirect rule of groups defined by race or ethnicity; and that corresponding French policies have emphasized direct rule and have been highly assimilationist. It demonstrates that the two countries are not as different as often portrayed. It also pinpoints the specific paths through which colonial legacies influenced integration policies, while rejecting the thesis that colonial institutions have broadly informed integration policies in Britain or France. The article thus challenges a series of received ideas, replacing them with a more precise assessment of the relations between the colonial past and the integration present.  相似文献   
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Previous research highlighted the correlation between parent–infant's attachment quality and joint attention skills. However, the underlying mechanisms of this relationship are still unclear. The aim of this study was to assess whether it is by mediating the expectation component in Internal Working Models that the quality of attachment style can affect joint attention. At first, 12- to 20-month-old infants were classified into secure and insecure groups using the Strange Situation Procedure. On a following day, using a violation-of-expectation paradigm, infants were habituated to two joint attention videos. Finally, the mean looking time duration of secure and insecure infants were compared with each other between two “divergent attention” and “joint attention” videos. Infants looked longer for divergent attention videos suggesting they did have expectation regarding the appropriate response in triadic interactions. In line with our main hypothesis, secure infants, but not insecure ones, looked longer in the divergent attention situation when an attachment-related context was present, revealing the possible mediating role of “expectations” in the correlation between attachment and joint attention.  相似文献   
79.
Population and Environment - It is well-known that men and women differ in their views regarding the severity of climate change, but do they also differ in their support for climate policy and in...  相似文献   
80.
Since the first electrification systems were established in the United States between 1910 and 1930, energy systems governance at the municipal level has included competing visions for how engineering design and energy policy-making should foster particular social outcomes. Using Phoenix as a representative metropolitan area, and the cases of distributed generation and in-home power management devices as examples, this paper explores how the norms and values embedded in energy systems design and planning shape how residents experience change in the energy grid. Through these case studies, the authors argue that such “sociotechnical imaginaries” – collectively formed visions of social life related to science and technology development – are a crucial, yet overlooked, pathway for social science to engage in fostering socially reflexive mechanisms in energy development. To conclude, the authors outline a research program for applying the established methodology of socio-technical integration research (STIR) in order to develop socially reflexive capacities in municipal energy producing, regulating, and planning institutions. Such a program has the ability to produce a deeper intellectual understanding of how energy development occurs, and in doing so generate new pathways for fostering cultural and material changes in the structure of contemporary energy systems.  相似文献   
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