Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin‐releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.     

Zero-inflated sum of Conway-Maxwell-Poissons (ZISCMP) regression

While excess zeros are often thought to cause data over-dispersion (i.e. when the variance exceeds the mean), this implication is not absolute. One should instead consider a flexible class of distributions that can address data dispersion along with excess zeros. This work develops a zero-inflated sum-of-Conway-Maxwell-Poissons (ZISCMP) regression as a flexible analysis tool to model count data that express significant data dispersion and contain excess zeros. This class of models contains several special case zero-inflated regressions, including zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), zero-inflated binomial (ZIB), and the zero-inflated Conway-Maxwell-Poisson (ZICMP). Through simulated and real data examples, we demonstrate class flexibility and usefulness. We further utilize it to analyze shark species data from Australia's Great Barrier Reef to assess the environmental impact of human action on the number of various species of sharks.     

Quantile regression for large-scale data via sparse exponential transform method

In recent decades, quantile regression has received much more attention from academics and practitioners. However, most of existing computational algorithms are only effective for small or moderate size problems. They cannot solve quantile regression with large-scale data reliably and efficiently. To this end, we propose a new algorithm to implement quantile regression on large-scale data using the sparse exponential transform (SET) method. This algorithm mainly constructs a well-conditioned basis and a sampling matrix to reduce the number of observations. It then solves a quantile regression problem on this reduced matrix and obtains an approximate solution. Through simulation studies and empirical analysis of a 5% sample of the US 2000 Census data, we demonstrate efficiency of the SET-based algorithm. Numerical results indicate that our new algorithm is effective in terms of computation time and performs well for large-scale quantile regression.     

Participation in Everyday Life Before and After a Housing Adaptation

Housing adaptation aims to enable clients to live independently in their own homes. Studies focusing on participation in everyday life following a housing adaptation are lacking and needed. This study aimed to explore housing adaptation clients' experiences of participation in everyday life before and after a housing adaptation, through the lens of a housing adaptation, using a qualitative follow-up design, with 11 participants. It was found that when the housing adaptation met the participants' needs, performance of activities improved and the housing adaptation opened doors to engagement and participation in everyday life. Thus, focus on performance and engagement in everyday life at the onset of the housing adaptation process, combined with regular follow-ups, may enhance participation.     

Que faut‐il voir dans les écarts de rémunération entre les travailleurs immigrés des pays du Golfe: l'effet d'a priori patronaux ou la simple conséquence de coûts d'opportunité différents?

Les auteurs s'intéressent aux disparités salariales entre les différents groupes de migrants qualifiés qui travaillent en grand nombre pour le secteur privé dans les États du Conseil de coopération du Golfe. Ils se demandent notamment si la prime salariale des Occidentaux (par rapport aux travailleurs venus d'Asie ou d'autres États arabes) découle d'éventuels a priori des employeurs. L'analyse, qui repose sur des données de 2012–2014 et sur deux méthodes de décomposition classiques, infirme l'hypothèse: les caractéristiques observables relatives à la productivité expliquent entre un tiers et trois quarts des écarts; le coût d'opportunité de la migration, supérieur pour les Occidentaux, explique la portion restante.     

Shyness,Preference for Solitude,and Adolescent Internalizing: The Roles of Maternal,Paternal, and Best‐Friend Support

The researchers examined differential outcomes related to two distinct motivations for withdrawal (preference for solitude and shyness) as well as the possibility that support from important others (mothers, fathers, and best friends) attenuate any such links. Adolescents (159 males, 171 females) reported on their motivations to withdraw, internalizing symptoms, and relationship quality in eighth grade, as well as their anxiety and depression in ninth grade. Using structural equation modeling, the authors found that maternal support weakened the association between shyness and internalizing problems; friend support weakened the association between preference for solitude and depression; and friend support strengthened the association between shyness and depression. Results suggest that shy adolescents may not derive the same benefits from supportive friendships as their typical peers.     

Urbanization-related distribution patterns and habitat-use by the marine mesopredator,giant Pacific octopus (<Emphasis Type="Italic">Enteroctopus dofleini</Emphasis>)

Urbanization is a process that heavily alters marine and terrestrial environments, though terrestrial urban ecosystems have been studied far more intensively. Terrestrial studies suggest that urbanization can facilitate mesopredators by enhancing food and shelter resources and reducing predation pressure from apex consumers. This in turn has considerable consequences for ecological communities. We evaluated spatial distribution patterns and habitat-use of the marine mesopredator, giant Pacific octopus (Enteroctopus dofleini), relative to terrestrial urbanization intensity in Puget Sound, Washington, USA. Using field surveys and citizen-contributed data for E. dofleini, we examined whether: (1) Distribution was related to urbanization, (2) Abundance was related to the extent of benthic anthropogenic debris, and (3) Diet differed as a function of urbanization and den cover. Our results suggest that urbanization impacts may differ with depth. Mixed-effects logistic regression model estimates for the probability of occurrence increased with urbanization in deep-water (> 24 m), and decreased with urbanization in shallow water (< 18 m). Accompanying field surveys indicated that E. dofleini abundance was correlated with the number of benthic anthropogenic debris items, and that E. dofleini diets were not affected by urbanization intensity or den cover. Though E. dofleini may be synanthropic within certain urban environments, the mechanisms driving this pattern likely differ from those affecting common urban mesopredators on land, with den provisioning from man-made structures being more important than altered food resources.     

Spatial Inequality in Access to Food Assistance in Indiana

This project is an analysis of the spatial inequality that exists between rural and urban areas in access to food assistance agencies. I gathered the population of all food pantries and soup kitchens in 24 sample counties in Indiana and mapped the location of these agencies using geographic information system analysis. Using the population center of the census block group, I measured the distance from the population center to the nearest food assistance agency. If the closest agency was more than a mile away, the census block group was considered a food assistance desert, a concept I created that draws on the food desert measurement. I found that rural high‐poverty counties in my sample are the most likely to contain census block groups that are food assistance deserts, and urban high‐poverty counties are the least likely to contain food assistance deserts. From these findings, I determine that access to assistance agencies needs to be increased in rural areas, especially rural areas with high‐poverty rates.     

Gaining by giving? Peer research into service user and carer perceptions of inclusivity in Higher Education

Abstract

Service users and carers (SUAC) have made significant contributions to professional training in social work courses in Higher Education (HE) over the past decade in the UK. Such participation has been championed by government, academics and SUAC groups from a range of theoretical and political perspectives. Most research into the effectiveness of SUAC involvement at HE has come from the perspectives of academics and very little SUAC-led research exists. This qualitative peer research was led by two members of the University of Worcester’s SUAC group. Findings were that SUAC perceived their involvement brought benefits to students, staff, the University and the local community. Significant personal benefits such as finding a new support network, increased self-development and greater confidence to manage their own care were identified in ways that suggested that the benefits that can flow from SUAC involvement at HE are perhaps more far-reaching than previously recognised. Barriers to inclusion were less than previously reported in the literature and the humanising effects of SUAC involvement are presented as a partial antidote to an increasingly marketised HE culture.