The influence of FDA advisory information and black box warnings on individual use of prescription antidepressants

We examine how use of antidepressant medications is influenced by Food and Drug Administration (FDA) warnings about the increased risk of suicidality associated with pediatric antidepressant use. With individual-level data on antidepressant use from the Medical Expenditure Panel Survey, we consider whether consumer responses to FDA warnings differ among targeted (children) and non-targeted (adult) age-groups. Because the warning labels specifically mentioned new users, we examine separately the effects of the warnings on initiations of antidepressant therapy and on continued use of antidepressants. We find evidence consistent with reduced initiation of antidepressant use among the intended population of children, and that usage among children with more highly educated parents responded earlier to FDA information. However, we also find spillover effects of reduced initiation among the non-targeted population of adults. Overall, our results indicate that the FDA warning may have led consumers to perceive risks beyond those specifically mentioned.     

Dynamic factor structure of team performances in Liga MX

Team performance of the Mexican Football League (Liga MX), measured as the percentage of the total points obtained during each short tournament, is analyzed using Dynamic Factor Models (DFMs). The estimation of the common components is carried out with Principal Components and the stochastic nature of the DFM is studied through Panel Analysis of Non-stationarity in Idiosyncratic and Common Components. The results reveal that there are two common factors, one being possibly non-stationary. These factors show an interesting dynamic behavior in the league and allow to split the teams into two groups, namely, top competitors and emerging or relegated teams. Some discussion is given in this direction.     

Bivariate Birnbaum-Saunders accelerated lifetime model: estimation and diagnostic analysis

In this paper, we discuss the bivariate Birnbaum-Saunders accelerated lifetime model, in which we have modeled the dependence structure of bivariate survival data through the use of frailty models. Specifically, we propose the bivariate model Birnbaum-Saunders with the following frailty distributions: gamma, positive stable and logarithmic series. We present a study of inference and diagnostic analysis for the proposed model, more concisely, are proposed a diagnostic analysis based in local influence and residual analysis to assess the fit model, as well as, to detect influential observations. In this regard, we derived the normal curvatures of local influence under different perturbation schemes and we performed some simulation studies for assessing the potential of residuals to detect misspecification in the systematic component, the presence in the stochastic component of the model and to detect outliers. Finally, we apply the methodology studied to real data set from recurrence in times of infections of 38 kidney patients using a portable dialysis machine, we analyzed these data considering independence within the pairs and using the bivariate Birnbaum-Saunders accelerated lifetime model, so that we could make a comparison and verify the importance of modeling dependence within the times of infection associated with the same patient.     

AD HOC MODEL BUILDING USING TIME-VARYING PARAMETER MODELS*

Decision support for managers and policy makers, such as required in planning and evaluation efforts, often requires ad hoc behavioral modeling to account for context-specific phenomena and to handle data limitations. This paper introduces a systematic approach useful for meeting these requirements in which time-varying parameter estimation plays an important role. A case study evaluating the impacts of public policy actions on residential natural gas conservation illustrates the approach.     

Applications and Implementation DECISION SUPPORT SYSTEMS: AN EMPIRICAL ASSESSMENT FOR DECISION MAKING

A laboratory experiment examined the effects of applying decision support system (DSS) technology to decision making in ill-structured problem environments under varying information conditions. Marketing executives participated in the experiment which investigated the effects of DSS availability, DSS training, and data availability on dependent variables that included: (1) the number of alternatives considered by a subject during decision making, (2) the period of time spent by a subject to complete the decision-making process, (3) the subject's perceived confidence in the decisions he or she had made, (4) the amount of data considered by a subject's during decision making, (5) the individual subject's decision processing, and (6) the subject's performance overall. Our results indicate that all three factors significantly affect the number of alternatives considered by subjects during the decision-making process. We therefore suggest that DSS training be coordinated with decision training in order to realize the potential of DSSs as described in the DSS literature.     

ON MODELING ADVERTISING PULSING DECISIONS

Based on empirical findings in the literature, sales response to advertising pulsing policy (APP) is modeled mathematically. The implications for APP are discussed. This policy is compared with an alternative policy of uniform expenditures (UAP), a commonly used strategy. The results of the research indicate that substantial savings in advertising budget or an increase in sales revenues may be achieved for a firm using APP.     

Enhancing Student Gerocompetencies: Evaluation of an Intergenerational Service Learning Course

This article describes the development and evaluation of an intergenerational service-learning course designed to promote social work gerocompetencies. Service-learning opportunities were structured into the course, including an optional evidence-based falls prevention program, for older adults, entitled A Matter of Balance (MOB). Significant differences between pre- and posttest scores on the Geriatric Social Work Competency Scale (GSWCS) were noted for students in the service learning course (n = 13). Once MOB was introduced as an independent variable, the MOB participants scored the highest mean posttest scores for 2 GSWCS domains: values, ethics, and theoretical perspectives; and intervention. The benefits of utilizing social work gerocompetencies to guide course objectives, content, and student outcomes are discussed.     

Foreign-born health integration during the transition to adulthood: The case of weight

Nativity differences in youths’ health in the United States are striking—the children of foreign-born parents often have healthier outcomes than those of native-born parents. However, very little is known about how immigrant-native differences evolve within the same individuals over time, or about life cycle aspects of the health-related integration of youth with migration backgrounds. Using data from the National Longitudinal Study of Adolescent Health, I examine nativity differences in trajectories of weight gain during adolescence and early adulthood, as well as the degree to which temporal patterns are stratified by race/ethnicity and socioeconomic status. I examine whether nativity differences converge, diverge or remain stable over time, and whether patterns are socially stratified within and across nativity groups. I find that first-generation adolescents begin at a lower weight than their third generation peers and gain weight at a significantly slower pace, resulting in meaningful differences by early adulthood. More complex examination of the relationship between nativity and weight gain reveals additional differences by ethnicity: the foreign-born advantage over time does not extend as strongly to Hispanic adolescents. The findings demonstrate how the health-related integration of foreign-born youth is tied to race/ethnicity and socioeconomic circumstances, and suggest the need to examine the ways in which social circumstances and health change together.     

ISO 45001 and controversial transnational private regulation for occupational health and safety

This article analyses the genesis of the ISO 45001 standard on occupational health and safety, a new initiative of transnational private regulation. The authors draw a picture of controversy from interviews with stakeholders involved in its design, approval and initial dissemination, and from a qualitative content analysis of the internal documentation of the committee responsible for its approval. Like its predecessors relating to environmental management – ISO 14001 – and corporate social responsibility – ISO 26000 – this new standard raises serious concerns among stakeholders given that it deals with substantive political, social and legal issues.