Menopause and sexual desire: the role of testosterone

The present short review underlines the role of testosterone (T) in the motivational and satisfaction components of women's sexuality and critically discusses the strategies to treat hypoactive sexual desire disorder (HSDD), a condition of low desire associated with personal and/or interpersonal difficulties, which is more common in surgical menopausal women. There are multiple ways androgens target the brain regions (hypothalamic, limbic and cortical) involved in sexual function and behaviour. Even though circulating available androgens have been implicated in several domains of sexual response, they seem to be related weakly to symptoms, such as low sexual desire, poor sexual arousal, orgasm and diminished well-being in postmenopausal women. The possibilities of treating low sexual desire/HSDD are multifaceted and should include the combination of pharmacological treatments able to maximize biological signals driving the sexual response, and individualized psychosocial therapies in order to overcome personal and relational difficulties. Transdermal T has been shown to be effective at a dose of 300 μg/day both in surgically and naturally menopausal women replaced with estrogen or not, without any relevant side-effects. However, the decision to treat postmenopausal women with HSDD with T is mainly based on clinical judgement, after informed consent regarding the unknown long-term risks.     

Assessing potential hybridization between a hypothetical gene drive-modified Drosophila suzukii and nontarget Drosophila species

Genetically engineered gene drives (geGD) are potentially powerful tools for suppressing or even eradicating populations of pest insects. Before living geGD insects can be released into the environment, they must pass an environmental risk assessment to ensure that their release will not cause unacceptable harm to non-targeted entities of the environment. A key research question concerns the likelihood that nontarget species will acquire the functional GD elements; such acquisition could lead to reduced abundance or loss of those species and to a disruption of the ecosystem services they provide. The main route for gene flow is through hybridization between the geGD insect strain and closely related species that co-occur in the area of release and its expected dispersal. Using the invasive spotted-wing drosophila, Drosophila suzukii, as a case study, we provide a generally applicable strategy on how a combination of interspecific hybridization experiments, behavioral observations, and molecular genetic analyses can be used to assess the potential for hybridization.     

Differential Mortality and the Design of the Italian System of Public Pensions

Abstract. This paper considers the issue of actuarial fairness of the new Italian public pension system in view of the recent trends in old‐age mortality and the survival differences by gender, birth cohort and region of residence. After reviewing the secular trends in elderly mortality in Italy, and the evolution of regional differences in survival over the last three decades, we evaluate the impact, on the conversion factors introduced by the Dini reform, of a further decline in elderly mortality over the next few decades. We compute the conversion factors using a close approximation to the unknown formula employed in the Dini reform but allowing for gender‐ and region‐specific survival probabilities. Our results leave no doubt about the importance of frequently updating the conversion factors in the light of the rapid increase in elderly survival. The paper also quantifies to what extent gender‐ and region‐specific conversion factors may differ from their currently legislated values, that only vary by age. Finally, we recognize that the actuarial fairness of the system introduced by the recent reform can only be guaranteed on average and that, in the presence of a heterogeneous population of individuals that differ considerably in their mortality prospects, the current system implies a substantial degree of redistribution from high‐mortality groups (typically characterized by low income and low wealth) to low‐mortality groups (typically characterized by high income and high wealth).     

Meeting in the mist: Key considerations in a collaborative research partnership with people with mental health issues

Objectives: This study explored the experiences of an established collaborative research group, which were collected as data to gain research skills. Currently ideas about user involvement and knowledge transfer have not been considered together, indicating possible gaps in knowledge. Participants: Eight members of the group took part, including five people using local mental health services, an assistant and an occupational therapist from local services, and an academic. Methods: Experiences of collaborative working were explored in phases. Structured individual reflections were recorded and shared for initial analysis. A group discussion prepared for constant comparative analysis, which synthesized the emerging themes. Results: Participants had gained and shared skills, understanding and knowledge. "Meeting in the mist" was a metaphor to explain the journeys experienced by participants, within a collaborative cycle. This cycle was central to a visual model, "Creating space", which suggested the importance of allowing sufficient time and space to work for a shared vision of the future. A final theme was the "warp factor", which drew on relativity theory to highlight the sense of innovation. Conclusions: Collaborative work can be based on knowledge transfer and ideas about user involvement, generating tangible benefits for all involved, including engaging in productive occupations.     

QUANTIFYING THE DETERRENT EFFECT OF ANTICARTEL ENFORCEMENT

This paper presents a rare attempt to quantify the deterrent effect of anticartel policy. It develops a conceptual framework, which establishes the sort of information necessary for such quantification. This is then illustrated and calibrated by drawing upon existing literatures and using evidence from legal cartels to approximate what would be observed absent policy. Measuring impact by the proportion of all potential harm that is deterred, our best estimate is two‐thirds and, even on conservative assumptions, at least half of all harms (or seven times the detected harm) is deterred. (JEL H11, K21, L44)     

Posttraumatic stress disorder and older women

This article examines the literature related to the identification and treatment of post traumatic stress disorder in older women. From this review, several key findings emerge. Consistent in the research literature is the fact that American women are more at risk for PTSD than are men as a result of the high frequency of sexual and domestic physical abuse that women experience. Studies on older women and PTSD indicate that older women are underdiagnosed and are more typically perceived as suffering from depression, anxiety or poor physical health. It was found consistently that older women who present with age-related stressors may not be asked about earlier trauma history or it may not be understood within the context of trauma related variables. In several research studies, trauma history was often not identified either as a result of current assessment practice or because women from certain age cohorts did not disclose trauma-related data to health professionals. Key researchers emphasize the necessity of clinicians, staff and medical personnel to attend to the historical variables present in trauma histories of older women. Researchers underscore the importance of understanding the impact of early and repeated trauma, especially interpersonal trauma, on the physical health and social functioning of older women- even though a significant amount of time may have elapsed since exposure. These findings indicate that further study of PTSD in older women is warranted. The paper concludes with a discussion of assessment and treatment options.     

Sing for me,Mama! Infants' discrimination of novel vowels in song

When adults speak or sing with infants, they sound differently than in adult communication. Infant-directed (ID) communication helps caregivers to regulate infants' emotions and helps infants to process speech information, at least from ID-speech. However, it is largely unclear whether infants might also process speech information presented in ID-singing. Therefore, we examined whether infants discriminate vowels in ID-singing, as well as potential differences with ID-speech. Using an alternating trial preference procedure, infants aged 4–6 and 8–10 months were tested on their discrimination of an unfamiliar non-native vowel contrast presented in ID-like speech and singing. Relying on models of early speech sound perception, we expected that infants in their first half year of life would discriminate the vowels, in contrast to older infants whose non-native sound perception should deteriorate, at least in ID-like speech. Our results showed that infants of both age groups were able to discriminate the vowels in ID-like singing, while only the younger group discriminated the vowels in ID-like speech. These results show that infants process speech sound information in song from early on. They also hint at diverging perceptual or attentional mechanisms guiding infants' sound processing in ID-speech versus ID-singing toward the end of the first year of life.     

Board characteristics effects on performance in family and non-family business: a multi-theoretical approach

This paper examines the role of the board of directors in influencing the value of Italian listed firms from 2003 to 2013. In particular, employing agency, stewardship and resource dependence theories, the study aims to compare board characteristics in family and non-family firms and define the theory that best applies to family firms. Empirical results show that the presence of CEO duality and busy directors has a positive effect on the value of family firms, while gender diversity has a negative impact on the value when a member of the family leads a family firm. Conversely, the size of the board positively affects the value of non-family firms. Our main findings suggest the prevalence, in family firms, of the benefits of the board structure argued by stewardship and resource dependence theories rather than the disadvantages expected from agency theory.     

Socio-demographic Components of Eudaimonic Well-Being: A Survey in an Italian Province

This work is part of a well-established strand of study about quality of life (QoL) and the different methodologies for its quantitative evaluation. The study focuses on a specific dimension of QoL, that of the eudaimonic well-being (EuWB), with two main objectives. On the one hand, we try to clarify how EuWB can be framed in the systematizations of QoL proposed in the literature. Its relation to the concept of subjective well-being is discussed, and the need to distinguish such approach from the so-called hedonic dimension of QoL is highlighted. On the other hand, the paper aims to investigate the link between the perception of EuWB and individual socio-demographic characteristics through a quantitative analysis based on the results of a survey. The survey carried out in Central Italy in 2010, involved a sample of 1,134 individuals, which are classified according to their perception of EuWB. An analysis of the socio-demographic characteristics within the EuWB groups is then performed in order to investigate the association between these variables and the perception of EuWB. Results are discussed with respect to the evidences from similar surveys found in the literature. The analysis confirms the influence of some variables on the perception of EuWB, yet it underlines the difficulty in comparing different studies on QoL without clarifying to which of the different declensions of this concept the survey methodology refers to.     

Experience of Career‐Related Discrimination for Female‐to‐Male Transgender Persons: A Qualitative Study

In this qualitative study, the authors examined the experience of discrimination and its relationship to the career development trajectory of 9 female‐to‐male transgender persons. Participants were between 21 and 48 years old and had a variety of vocational experiences. Individual semistructured interviews were conducted via telephone and analyzed using grounded theory methodology. The emergent model consisted of forms of discrimination and impact of discrimination. These components intersected with the career development trajectory. Participants provided their own suggestions for improving the workplace environment. Counseling, advocacy, and future research implications are discussed.