Evaluation of program success for programs with multiple trials in binary outcomes

A late‐stage clinical development program typically contains multiple trials. Conventionally, the program's success or failure may not be known until the completion of all trials. Nowadays, interim analyses are often used to allow evaluation for early success and/or futility for each individual study by calculating conditional power, predictive power and other indexes. It presents a good opportunity for us to estimate the probability of program success (POPS) for the entire clinical development earlier. The sponsor may abandon the program early if the estimated POPS is very low and therefore permit resource savings and reallocation to other products. We provide a method to calculate probability of success (POS) at an individual study level and also POPS for clinical programs with multiple trials in binary outcomes. Methods for calculating variation and confidence measures of POS and POPS and timing for interim analysis will be discussed and evaluated through simulations. We also illustrate our approaches on historical data retrospectively from a completed clinical program for depression. Copyright © 2015 John Wiley & Sons, Ltd.     

Understanding preferences for tree attributes: the relative effects of socio-economic and local environmental factors

Urban plant biodiversity is influenced by both the physical environment and attitudes and preferences of urban residents for specific plant types. Urban residents are assumed to be disconnected from their immediate environment, and cultural and societal factors have been emphasized over environmental factors in studies of landscaping choices. However, we postulate that local climatic and environmental factors can also affect preferences for plant attributes. Therefore, spatial and temporal patterns in urban tree biodiversity may be driven not only by the direct effect of environmental variables on plant function, but also by the effect of environmental variables on attitudes toward trees and associated choices about which types of trees to plant. Here, we tested the relative effects of socio-economic and local environmental factors on preferences toward tree attributes in five counties in southern California in and surrounding Los Angeles, based on 1,029 household surveys. We found that local environmental factors have as strong an effect on preferences for tree attributes as socio-economic factors. Specifically, people located in hotter climates (average maximum temperature 25.1 °C) were more likely to value shade trees than those located in cooler regions (23.1 °C). Additionally, people located in desert areas were less likely to consider trees to be important in their city compared with people located in naturally forested areas. Overall, our research demonstrates the inherent connections between local environmental factors and perceptions of nature, even in large modern cities. Accounting for these factors can contribute to the growing interest in understanding patterns of urban biodiversity.     

Identity Development in a Transracial Environment: Racial/Ethnic Minority Adoptees in Minnesota

It has been argued that transracially adopted children have increased risk of problems related to self-esteem and ethnic identity development. We evaluated this hypothesis across four groups of transracial adoptees: Asian (n = 427), Latino (n = 28), Black (n = 6), mixed/other (n = 20), and same-race White adoptees (n = 126) from 357 adoptive families. No mean differences were found in adoptees’ ratings of affect about adoption or of curiosity about birth parents. Some differences were found in general identity development and adjustment. There were notable differences in communication about race/ethnicity across groups and between parent and child report.     

Using repeated-prevalence data in multi-state modeling of renal replacement therapy

Multi-state models help predict future numbers of patients requiring specific treatments but these models require exhaustive incidence data. Deriving reliable predictions from repeated-prevalence data would be helpful. A new method to model the number of patients that switch between therapeutic modalities using repeated-prevalence data is presented and illustrated. The parameters and goodness of fit obtained with the new method and repeated-prevalence data were compared to those obtained with the classical method and incidence data. The multi-state model parameters’ confidence intervals obtained with annually collected repeated-prevalence data were wider than those obtained with incidence data and six out of nine pairs of confidence intervals did not overlap. However, most parameters were of the same order of magnitude and the predicted patient distributions among various renal replacement therapies were similar regardless of the type of data used. In the absence of incidence data, a multi-state model can still be successfully built with annually collected repeated-prevalence data to predict the numbers of patients requiring specific treatments. This modeling technique can be extended to other chronic diseases.     

Wavelet Shrinkage with Double Weibull Prior

In this article, we propose a denoising methodology in the wavelet domain based on a Bayesian hierarchical model using Double Weibull prior. We propose two estimators, one based on posterior mean (Double Weibull Wavelet Shrinker, DWWS) and the other based on larger posterior mode (DWWS-LPM), and show how to calculate them efficiently. Traditionally, mixture priors have been used for modeling sparse wavelet coefficients. The interesting feature of this article is the use of non-mixture prior. We show that the methodology provides good denoising performance, comparable even to state-of-the-art methods that use mixture priors and empirical Bayes setting of hyperparameters, which is demonstrated by extensive simulations on standardly used test functions. An application to real-word dataset is also considered.     

Regression Methods for Combining Multiple Classifiers

As no single classification method outperforms other classification methods under all circumstances, decision-makers may solve a classification problem using several classification methods and examine their performance for classification purposes in the learning set. Based on this performance, better classification methods might be adopted and poor methods might be avoided. However, which single classification method is the best to predict the classification of new observations is still not clear, especially when some methods offer similar classification performance in the learning set. In this article we present various regression and classical methods, which combine several classification methods to predict the classification of new observations. The quality of the combined classifiers is examined on some real data. Nonparametric regression is the best method of combining classifiers.     

Corporate political power and US foreign policy, 1981–2002: the role of the policy-planning network

Theory and Society - Recent empirical work has offered strong support for ‘biased pluralism’ and ‘economic elite’ accounts of political power in the United States, according...     

Food Insecurity Measurement: Stakeholder Comparisons of the EU-SILC and HFSSM Indicators and Considerations Towards the Usefulness of a Headline Indicator

Social Indicators Research - Prior to the February 2019 announcement that the Household Food Security Survey Module (HFSSM) will be used to estimate household food insecurity, there has not been a...