A Unified Approach of Meta-Analysis: Application to an Antecedent Biomarker Study in Alzheimer's Disease

This article provides a unified methodology of meta-analysis that synthesizes medical evidence by using both available individual patient data (IPD) and published summary statistics within the framework of likelihood principle. Most up-to-date scientific evidence on medicine is crucial information not only to consumers but also to decision makers, and can only be obtained when existing evidence from the literature and the most recent individual patient data are optimally synthesized. We propose a general linear mixed effects model to conduct meta-analyses when individual patient data are only available for some of the studies and summary statistics have to be used for the rest of the studies. Our approach includes both the traditional meta-analyses in which only summary statistics are available for all studies and the other extreme case in which individual patient data are available for all studies as special examples. We implement the proposed model with statistical procedures from standard computing packages. We provide measures of heterogeneity based on the proposed model. Finally, we demonstrate the proposed methodology through a real life example studying the cerebrospinal fluid biomarkers to identify individuals with high risk of developing Alzheimer's disease when they are still cognitively normal.     

Generalised data augmentation and posterior inferences

This paper explores the use of data augmentation in settings beyond the standard Bayesian one. In particular, we show that, after proposing an appropriate generalised data-augmentation principle, it is possible to extend the range of sampling situations in which fiducial methods can be applied by constructing Markov chains whose stationary distributions represent valid posterior inferences on model parameters. Some properties of these chains are presented and a number of open questions are discussed. We also use the approach to draw out connections between classical and Bayesian approaches in some standard settings.     

A Theoretical Perspective on Coping With Stigma

Stigmatized people have a vast array of responses to stressors resulting from their devalued social status, including emotional, cognitive, biological, and behavioral responses. This article uses existing theory and research on general stress and coping responses to describe responses to stigma-related stressors and to discuss the adaptiveness of these responses.     

Differences in perceptions of leadership between U.S. and Japanese workers

Differences between American and Japanese workers regarding perceptions of effective leadership were investigated. 128 American workers and 203 Japanese workers were asked to describe the characteristics of their ideal leader. Results indicated that Americans perceive personality characteristics as more important for leadership, whereas Japanese perceive skills and behaviors as more important for leadership. Suggestions are made for training leaders from the U.S. and Japan for cross-cultural situations and for future cross-cultural leadership research.     

Exploring the professor and student relationship after a life-threatening trauma

ABSTRACT

A professor shares his account of recovering from a near fatal bicycle accident in this article. The authors explore the professor/student relationship after this life-threatening accident. Using qualitative research methods, a purpose sample of students from a mid-size undergraduate social work program described their experiences of interacting with the professor after he returned to work. All the students in the sample took a course from the professor before the accident. All the students in the sample also knew about the severity of his injuries after the accident. Important themes of trauma emerged interwoven in the relationship between students and the professor. There are also important concepts mentioned in the article that look at the healing process that occurs between the students and the professor, where significant trauma has occurred in the life of a professor. Existing studies examine the professional/student relationship when the student experienced trauma. Administrators need to consider these important themes of trauma when a professor returns to work after a life-threatening accident.     

Investigating the role of orthogonal and non – orthogonal rotation in multivariate factor analysis,in regard to the repeatability of the extracted factors: A simulation study

ABSTRACT

Factor analysis (FA) is the most commonly used pattern recognition methodology in social and health research. A technique that may help to better retrieve true information from FA is the rotation of the information axes. The main goal is to test the reliability of the results derived through FA and to reveal the best rotation method under various scenarios. Based on the results of the simulations, it was observed that when applying non-orthogonal rotation, the results were more repeatable as compared to the orthogonal rotation, and, when no rotation was applied.     

Does Conservative Protestantism Moderate the Association Between Corporal Punishment and Child Outcomes?

Using longitudinal data from a sample of 456 focal children in the National Survey of Families and Households (NSFH), this study examined two research questions: (a) Does corporal punishment of young children (ages 2–4 at baseline) predict increases in levels of externalizing and internalizing problems over a 5‐year study period? (b) Does the religion of the mother—specifically, her conservative Protestant affiliation and conservative beliefs about the Bible—moderate the estimated net effects of corporal punishment? Results revealed that early spanking alone was not associated with adjustment difficulties, but spanking that persisted into or began in middle childhood was associated with difficulties. In contrast to their counterparts from other (or no) religious backgrounds, children whose mothers belonged to conservative Protestant groups exhibited minimal adverse effects of corporal punishment. Several conclusions, limitations, and promising directions for future research are identified.     

Confidence intervals and significance tests for a single trial

Confidence intervals are developed for the location parameter of a continuous, symmetric, unimodal distribution in the casev where only a single observation from the distribution is available. These intervals are similar to those given by Abbott and Rosenblatt (1963), but shorter. The result is extended to include distributions which can be standardized to have unit scale. The procedure is exemplified for the normal distribution and the power of one- and two-sided significance tests are computed under normality.