Non-concave penalization in linear mixed-effect models and regularized selection of fixed effects

Mixed-effect models are very popular for analyzing data with a hierarchical structure. In medical applications, typical examples include repeated observations within subjects in a longitudinal design, patients nested within centers in a multicenter design. However, recently, due to the medical advances, the number of fixed-effect covariates collected from each patient can be quite large, e.g., data on gene expressions of each patient, and all of these variables are not necessarily important for the outcome. So, it is very important to choose the relevant covariates correctly for obtaining the optimal inference for the overall study. On the other hand, the relevant random effects will often be low-dimensional and pre-specified. In this paper, we consider regularized selection of important fixed-effect variables in linear mixed-effect models along with maximum penalized likelihood estimation of both fixed and random-effect parameters based on general non-concave penalties. Asymptotic and variable selection consistency with oracle properties are proved for low-dimensional cases as well as for high dimensionality of non-polynomial order of sample size (number of parameters is much larger than sample size). We also provide a suitable computationally efficient algorithm for implementation. Additionally, all the theoretical results are proved for a general non-convex optimization problem that applies to several important situations well beyond the mixed model setup (like finite mixture of regressions) illustrating the huge range of applicability of our proposal.     

Career Adaptability and Occupational Engagement of Student Veterans

This study examined the specific career‐related behaviors of career adaptability and occupational engagement among student veterans (N = 100). Contrary to expectations, findings showed statistically significant negative correlations between career adaptability resources (control, concern, curiosity, and confidence) and occupational engagement. Multiple regression analyses indicated that the curiosity resource of career adaptability significantly predicted occupational engagement. The findings suggest a need to understand the complexity of career adaptability and occupational engagement in both research and practice for student veterans.     

The Gamma–Kumaraswamy distribution: An alternative to Gamma distribution

In this article, a new generalization of the Kumaraswamy distribution, namely the Gamma–Kumaraswamy distribution, is defined and studied. Various properties of the Gamma–Kumaraswamy are obtained. The structural analysis of the distribution in this article includes limiting behavior, mode, quantiles, moments, skewness, kurtosis, Shannon’s entropy, and order statistics. The method of maximum likelihood estimation is proposed for estimating the model parameters. For illustrative purposes, two real datasets are analyzed as application of the Gamma–Kumaraswamy distribution.     

On the Loss Robustness of Least-Square Estimators

Abstract

The article revisits univariate and multivariate linear regression models. It is shown that least-square estimators (LSEs) are minimum risk estimators in general class of linear unbiased estimators under some general divergence loss. This amounts to the loss robustness of LSEs.     

Influence of soil properties on street tree attributes in Singapore

Urban Ecosystems - Soil quality is thought to be a primary driver of street tree performance and thus a major concern for urban forest growth, health and longevity. This research was conducted to...     

Fast approximate Bayesian computation for estimating parameters in differential equations

Approximate Bayesian computation (ABC) using a sequential Monte Carlo method provides a comprehensive platform for parameter estimation, model selection and sensitivity analysis in differential equations. However, this method, like other Monte Carlo methods, incurs a significant computational cost as it requires explicit numerical integration of differential equations to carry out inference. In this paper we propose a novel method for circumventing the requirement of explicit integration by using derivatives of Gaussian processes to smooth the observations from which parameters are estimated. We evaluate our methods using synthetic data generated from model biological systems described by ordinary and delay differential equations. Upon comparing the performance of our method to existing ABC techniques, we demonstrate that it produces comparably reliable parameter estimates at a significantly reduced execution time.     

Bayesian classification of tumours by using gene expression data

Summary.  Precise classification of tumours is critical for the diagnosis and treatment of cancer. Diagnostic pathology has traditionally relied on macroscopic and microscopic histology and tumour morphology as the basis for the classification of tumours. Current classification frameworks, however, cannot discriminate between tumours with similar histopathologic features, which vary in clinical course and in response to treatment. In recent years, there has been a move towards the use of complementary deoxyribonucleic acid microarrays for the classi-fication of tumours. These high throughput assays provide relative messenger ribonucleic acid expression measurements simultaneously for thousands of genes. A key statistical task is to perform classification via different expression patterns. Gene expression profiles may offer more information than classical morphology and may provide an alternative to classical tumour diagnosis schemes. The paper considers several Bayesian classification methods based on reproducing kernel Hilbert spaces for the analysis of microarray data. We consider the logistic likelihood as well as likelihoods related to support vector machine models. It is shown through simulation and examples that support vector machine models with multiple shrinkage parameters produce fewer misclassification errors than several existing classical methods as well as Bayesian methods based on the logistic likelihood or those involving only one shrinkage parameter.     

An improved fuzzy time-series method of forecasting based on L–R fuzzy sets and its application

Classical time-series theory assumes values of the response variable to be ‘crisp’ or ‘precise’, which is quite often violated in reality. However, forecasting of such data can be carried out through fuzzy time-series analysis. This article presents an improved method of forecasting based on L–R fuzzy sets as membership functions. As an illustration, the methodology is employed for forecasting India's total foodgrain production. For the data under consideration, superiority of proposed method over other competing methods is demonstrated in respect of modelling and forecasting on the basis of mean square error and average relative error criteria. Finally, out-of-sample forecasts are also obtained.