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391.
Professor Eugene Sadler-Smith Peter J. Smith 《Human Resource Development International》2013,16(2):271-281
Abstract This paper outlines the limitations of a technical rationalist approach to HRD practice without seeking to negate it. It then offers a complementary view based on Schon's notion of the reflective practitioner which exhorts HRD practitioners to embrace complexity and reflection. We outline, first, a number of dimensions of diversity which confer complexity upon HRD practice, and, second, a series of suggested questions that may aid the framing of practical problems in a more effective way than might be the case with a purely technical rationalist approach. We urge novice (and expert) HRD practitioners to adopt a mind set that is contemplative of the diversities that they may encounter in practice and which is conjectural with regard to how these diversities may impact upon problems and their solutions. 相似文献
392.
Karpievitch YV Polpitiya AD Anderson GA Smith RD Dabney AR 《The annals of applied statistics》2010,4(4):1797-1823
Mass spectrometry-based proteomics has become the tool of choice for identifying and quantifying the proteome of an organism. Though recent years have seen a tremendous improvement in instrument performance and the computational tools used, significant challenges remain, and there are many opportunities for statisticians to make important contributions. In the most widely used "bottom-up" approach to proteomics, complex mixtures of proteins are first subjected to enzymatic cleavage, the resulting peptide products are separated based on chemical or physical properties and analyzed using a mass spectrometer. The two fundamental challenges in the analysis of bottom-up MS-based proteomics are: (1) Identifying the proteins that are present in a sample, and (2) Quantifying the abundance levels of the identified proteins. Both of these challenges require knowledge of the biological and technological context that gives rise to observed data, as well as the application of sound statistical principles for estimation and inference. We present an overview of bottom-up proteomics and outline the key statistical issues that arise in protein identification and quantification. 相似文献
393.
The theory of max-stable processes generalizes traditional univariate and multivariate extreme value theory by allowing for processes indexed by a time or space variable. We consider a particular class of max-stable processes, known as M4 processes, that are particularly well adapted to modeling the extreme behavior of multiple time series. We develop procedures for determining the order of an M4 process and for estimating the parameters. To illustrate the methods, some examples are given for modeling jumps in returns in multivariate financial time series. We introduce a new measure to quantify and predict the extreme co-movements in price returns. 相似文献
394.
This paper examines the processes of change in two ‘rural’ environs of Hebden Bridge, West Yorkshire, associated with the in-migration and consumption practices of relatively affluent households. In doing so, we address the knowledge gap identified by Phillips (J. Rural Studies 9 (1993) 123) relating to the gentrification of rural locations. The term ‘rural greentrification’ is suggested to emphasise the varying cultural predilections of in-migrant households in the consumption of ‘green’ spaces. More specifically, a geography of greentrification is identified in the locale, which encompasses two socio-spatial relationships: ‘village’and ‘remote’. These are interpreted as distinct constructions of rural ‘habitus’ and thus exemplify the significance of Hebden Bridge as a special place, where the multiple appeals and meanings of different representations of greentrified Pennine rurality enable cultural and social differentiation. The findings reaffirm the value of viewing the rural as a socio-cultural construct, tied to place and time, which is specific to individuals and social groups. 相似文献
395.
Risk Estimation and Value-of-Information Analysis for Three Proposed Genetic Screening Programs for Chronic Beryllium Disease Prevention 总被引:1,自引:0,他引:1
Scott M. Bartell Rafael A. Ponce Timothy K. Takaro Richard O. Zerbe Gilbert S. Omenn & Elaine M. Faustman 《Risk analysis》2000,20(1):87-100
Genetic differences (polymorphisms) among members of a population are thought to influence susceptibility to various environmental exposures. In practice, however, this information is rarely incorporated into quantitative risk assessment and risk management. We describe an analytic framework for predicting the risk reduction and value-of-information (VOI) resulting from specific risk management applications of genetic biomarkers, and we apply the framework to the example of occupational chronic beryllium disease (CBD), an immune-mediated pulmonary granulomatous disease. One described Human Leukocyte Antigen gene variant, HLA-DP beta 1*0201, contains a substitution of glutamate for lysine at position 69 that appears to have high sensitivity (approximately 94%) but low specificity (approximately 70%) with respect to CBD among individuals occupationally exposed to respirable beryllium. The expected postintervention CBD prevalence rates for using the genetic variant (1) as a required job placement screen, (2) as a medical screen for semiannual in place of annual lymphocyte proliferation testing, or (3) as a voluntary job placement screen are 0.08%, 0.8%, and 0.6%, respectively, in a hypothetical cohort with 1% baseline CBD prevalence. VOI analysis is used to examine the reduction in total social cost, calculated as the net value of disease reduction and financial expenditures, expected for proposed CBD intervention programs based on the genetic susceptibility test. For the example cohort, the expected net VOI per beryllium worker for genetically based testing and intervention is $13,000, $1,800, and $5,100, respectively, based on a health valuation of $1.45 million per CBD case avoided. VOI results for alternative CBD evaluations are also presented. Despite large parameter uncertainty, probabilistic analysis predicts generally positive utility for each of the three evaluated programs when avoidance of a CBD case is valued at $1 million or higher. Although the utility of a proposed risk management program may be evaluated solely in terms of risk reduction and financial costs, decisions about genetic testing and program implementation must also consider serious social, legal, and ethical factors. 相似文献
396.
Abstract Many rural communities in the Rocky Mountain West with high amenity values have experienced substantial in‐migration in the 1990s. Popular media accounts and some social science literature suggest that newcomers have very different values than longer‐term residents regarding environment, growth, and development issues, and that these differences are resulting in widespread social conflict. We evaluate these “culture clash” and “gangplank” hypotheses using survey data from three rural communities in the Rocky Mountain West that are experiencing amenity‐related in‐migration. We examine attitudes about environmental concern, population growth, economic development, and tourism development. Results indicate that newcomers differ significantly from longer‐term residents on a number of sociodemographic dimensions, but either there are no significant attitude differences between the two groups, or, where difference exist, longer‐term residents wish more strongly than newcomers to limit population growth and development in their communities. We offer explanations for why the results differ from media accounts and from the earlier research observations and hypotheses. 相似文献
397.
Judith R. Smith Jeanne Brooks‐Gunn Pamela K. Klebanov Kyunghee Lee 《Journal of marriage and the family》2000,62(3):808-821
We examine the effects of mothers' strategies of combining employment and welfare receipt during the first 3 years of their child's life on the child's cognitive development, behavior problems, and home learning environment at ages 5 to 6. We compare the child outcomes of those mothers who were continuously employed and received no welfare with (a) those who worked some or all of the 3 years and also received public assistance and (b) those who were totally dependent on public assistance. We studied children in single‐parent families (N= 1271 ) living below 200% of the poverty threshold using data from the National Longitudinal Survey of Youth—Child Supplement. No negative association was found on most child outcomes with a mother's employment whether or not it was combined with public assistance. However, mothers' not working at all and receiving financial support solely from AFDC was associated with negative child outcomes. We discuss the implications of these findings for the possible effects of the new welfare laws on families and young children. 相似文献
398.
Mystery or Typical Teen? The Social Construction of Academic Engagement and Disability 总被引:1,自引:0,他引:1
Robin M. Smith 《Disability & Society》2000,15(6):909-922
A qualitative study of academic engagement of five high school students labelled mentally retarded describes strategies of student participation and non-participation, and teacher perceptions. These students were non-verbal or inarticulate, and functioned in an environment of competing formal and informal assessments of their participation and understanding in the academic environment. Teachers' informal assessments of student participation revealed how the students challenged the conventional categories employed by teachers. The examples show the power of educators' perceptions to reveal or obscure student engagement. 相似文献
399.
400.
Anthony Gilbert Gloria Lankshear Alan Petersen 《International Journal of Social Welfare》2008,17(1):54-64
Over the past 20 years, research across the developed world has identified trends towards ageing of the population with learning/intellectual disability. Alongside is the recognition that family-carers are also ageing. Recently, the UK government has sought to identify the future housing needs of dependents with intellectual disability residing with older carers. Consequentially, a city council commissioned this qualitative study involving 28 older carers. The findings indicate a need for information about housing options, a lack of practical support and feelings of marginalisation. The conclusions suggest key roles for social services in providing proactive support and advice to family-carers, and a greater degree of joint working between social services departments and housing agencies. These resonate with similar international studies and provide the opportunity to focus on the perspectives of family-carers. Their experiences are real, and if welfare professionals are to work with people with intellectual disability and their family-carers, acknowledging their views is essential. 相似文献