Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study

Purpose: To investigate a possible relation between penile Doppler ultrasound examination (PDUE) parameters and efficacy of chronic therapy with tadalafil (TAD) combined with a protocol of aerobic physical activity (PA) in patients with late onset hypogonadism (LOH). Methods: The study evaluated 30 patients consecutively enrolled with LOH and erectile dysfunction which present contraindication to hormonal replacement therapy for concomitant prostate disease. These patients were subjected to a combined protocol with phosphodiesterase V selective inhibitors (TAD 5?mg daily) and aerobic PA.

Results: After three months, we observed significant improvements in erectile function [IIEF-5, median (IQR)?=?13.0 (7.0–18.0) versus 6.0 (5.0–6.75); p?p?Conclusion: PA in association with phosphodiesterase V inhibitors could compensate the effects of hypogonadism on erectile function and facilitate the clinical response to these drugs even in the absence of adequate serum concentrations of total testosterone.     

Ukraine Economy and Finance in the Reform Process and the European Partnership: A Focus on Aerospace Industry

In spite of economic stabilization and the growth rate uprise since 2003, Ukraine has received less than EUR 5 billion in foreign direct investment over the last five years (from 2000 to 2004). This is less than other less FDI-attractive countries got, notwithstanding the fact that Ukraine has a steel industry of international significance, great agriculture potential, and an automotive industry which accounts for almost 6% of the value added generated by the industrial sector. The new government of Ukraine has declared the foreign investment flows into Ukraine among its top priorities. Unfair competition as a result of past bad government policies was the reason for the low FDI inflow. The former Ukrainian government promoted private interests of a limited group of businessmen. Unfair privatization sales with a limited access of other investors, as well as violent ownership takeovers, took place. The new government has committed to stop this practice. The role of independent courts will grow in dealing with conflicts, including the revision of unfair privatization sales. The determination to be integrated with the EU represents an ultimate goal. Such a step is expected to facilitate Ukraine's movement towards European standards in all spheres. I also present a brief inside evaluation on the aerospace industry, for both the civil and military sectors, starting from a sketch of the defense industry in 2000. The situation of civil and military aviation in Russia and Ukraine has many points in common and it could not be different after such a prolonged common history in the same military-industrial complex. Ukrainian industrial capacity is more or less completely secluded from international partners and markets. EU and NATO should not miss the opportunity to take into account the human capital and the technology achievement already accumulated by Ukrainian industries, research centres, academies, laboratories. The Ukraine aviation industry has suffered a serious decline over the last 15 years. Only recently new programs and major developments in the sector, which is undergoing a major restructuring, have reopened the perspectives of new projects in both civil and military aviation, as well as in space projects. The components sectors will be affected positively if the developments will be confirmed by concrete international partnerships and investments, first of all with the EU and the United States. Mergers and restructuring of the existent production plants are a real need. As experience shows in Europe and in the global market, no national way or revival of past alliances could help Ukraine to maintain a role in the aerospace sector.     

%Gra: an SAS macro for generalized redundancy analysis

In the framework of redundancy analysis and reduced rank regression, the extended redundancy analysis model managed to account for more than two blocks of manifest variables in its specification. A further extension, the generalized redundancy analysis (GRA), has been recently proposed in literature, with the aim of incorporating external covariates into the model, thanks to a new estimation algorithm that manages to separate all the contributions of the exogenous and external covariates in the formation of the latent composites. At present, software to estimate GRA models is not available. In this paper, we provide an SAS macro, %GRA, to specify and fit structural relationships, with an application to illustrate the use of the macro.     

Technological change and technology monitoring process: Evidence from four Italian case studies

Technology monitoring (TM) may take on different meanings in a company’s day-to-day activities. In some cases it can be interpreted as a technology intelligence methodology, while in others it is understood as technology forecasting or even as technology assessment. These different interpretations are confirmed by an analysis of the literature. This case study examines the technology monitoring process in four Italian companies.For each of the cases considered, first we analysed the way technology monitoring is carried out and then we tried to understand what factors influence the company approach to technology monitoring. Four factors that can be expected to influence a company’s technology monitoring approach came out of this empirical research study: the industry a company operates in, the business model it uses, the importance of technology in the corporate culture, and the level of its R&D resources.     

On the max-weight edge coloring problem

We study the following generalization of the classical edge coloring problem: Given a weighted graph, find a partition of its edges into matchings (colors), each one of weight equal to the maximum weight of its edges, so that the total weight of the partition is minimized. We explore the frontier between polynomial and NP-hard variants of the problem, with respect to the class of the underlying graph, as well as the approximability of NP-hard variants. In particular, we present polynomial algorithms for bounded degree trees and star of chains, as well as an approximation algorithm for bipartite graphs of maximum degree at most twelve which beats the best known approximation ratios.     

Theories of International Relations: from an American Science Towards a Pluralism of Thought

The change was not only promised during Obama’s electoral campaign but urgently invoked by all the major international actors in view of the financial and economic crises: the world foreign policy has suddenly entered a new age not being yet prepared to govern globalization and its wide interdependence conditionality. Even Russia has changed tune now and President Medvedev announced vigorously a new strategy, a new policy, and a new drive for Russia. Until a few years ago, the theories of International Relations were simply an American intellectual and governance exit of the growing role of the US in the world, a kind of field of competence for the greatest power in the global economic, political, strategic and innovative sectors. The British School was an island of the core American thinking and the rest of the world mostly absent. FSU has not expressed a relevant contribution to the various schools of thinking related to the IR theories and even the Marxist political scientists did not dedicate specifically to this main research area because convinced that first it was not a real “science” but a derivative outcome from Philosophy or Political Science; secondly, for the reason of the monopoly of the power in the hands of an autocratic regime where these issues were not left to the researchers and experts but only to the institutional and military leadership. Today Russia—after having caressed and found opportunistically convenient to resume the realism doctrines of the past US almost decennial Presidency, with modest attempts to assume the great changes in international affairs intervened— has the chance to take the last train for a competitive power role, “de facto” under the unavoidable strict rules of engagement of the global governance. In the 2020–2030 the world would be completely reshape by the present metamorphosis.     

University Quality and Labour Market Outcomes in Italy

Abstract. This paper uses proxies for university quality derived from Performance Indicators to evaluate the impact of university quality on the early labour market outcome of a cohort of recent Italian graduates. Institutional research quality is found to have a negative effect on the probability that both male and female graduates will be overeducated. Additionally, research inputs are positively related to men's wages. In contrast, teaching quality does not appear to enhance students’ economic success.     

ENDOGENOUS NETWORKS IN RANDOM POPULATION GAMES

Population learning in dynamic economies traditionally has been studied in contexts where payoff landscapes are smooth. Here, dynamic population games take place over “rugged” landscapes, where agents are uncertain about payoffs from bilateral interactions. Notably, individual payoffs from playing a binary action against everyone else are uniformly distributed over [0, 1]. This random population game leads the population to adapt over time, with agents updating both actions and partners. Agents evaluate payoffs associated to networks thanks to simple statistics of the distributions of payoffs associated to all combinations of actions performed by agents out of the interaction set. Simulations show that: (1) allowing for endogenous networks implies higher average payoff compared to static networks; (2) the statistics used to evaluate payoffs affect convergence to steady-state; and (3) for statistics MIN or MAX, the likelihood of efficient population learning strongly depends on whether agents are change-averse or not in discriminating between options delivering the same expected payoff.