Late-onset hypogonadism: the advantages of treatment with human chorionic gonadotropin rather than testosterone

The traditional pharmacological treatment of patients with late onset hypogonadism (LOH) is represented by different formulations of testosterone (T) or alternatively by the extractive human chorionic gonadotropin (HCG). The hormone replacement treatment (HRT) is associated with the potential increase of hematocrit, serum concentrations of prostate-specific antigen (PSA) and prostate volume. Moreover, the gynecomastia represent a condition frequently associated with HRT. Recent evidences showed the role of leydig cells in the 25-hydroxylation of vitamin D and the elevated frequency of hypovitaminosis D among LOH patients. Finally, another important aspect of LOH is represented by the frequency of secondary infertility due to age or to traditional HRT. This study evaluated 40 LOH patients treated for 6 months with extractive HCG (n?=?10 patients) and three different formulations of T: transdermal (n?=?10 patients), undecaonate (n?=?10 patients) and enantate (n?=?10 patients). Hormonal, anthropometric, metabolic and sperm parameters were evaluated and compared. Moreover, the main safety parameters and the results of the main questionnaires were evaluated. After treatment, HCG group showed serum concentrations of 25-OH-vitamin D significantly higher (p?p?p?p?相似文献   

A spatial analysis of health and pharmaceutical firm survival

The presence of knowledge spillovers and shared human capital is at the heart of the Marhall–Arrow–Romer externalities hypothesis. Most of the earlier empirical contributions on knowledge externalities; however, considered data aggregated at a regional level so that conclusions are based on the arbitrary definition of jurisdictional spatial units: this is the essence of the so-called modifiable areal unit problem. A second limitation of these studies is constituted by the fact that, somewhat surprisingly, while concentrating on the effects of agglomeration on firm creation and growth, the literature has, conversely, largely ignored its effects on firm survival. The present paper aims at contributing to the existing literature by answering to some of the open methodological questions reconciling the literature of Cox proportional hazards model with that on point pattern and thus capturing the true nature of spatial information. We also present some empirical results based on Italian firm demography data collected and managed by the Italian National Institute of Statistics (ISTAT).     

Maternal Vocal Interactions with Infants: Reciprocal Visual Influences

The present study examined the influence of infant visual cues on maternal vocal and facial expressiveness while speaking or singing and the influence of maternal visual cues on infant attention. Experiment 1 asked whether mothers exhibit more vocal emotion when speaking and singing to infants in or out of view. Adults judged which of each pair of audio excerpts (in view, out of view) sounded more emotional. Face‐to‐face vocalizations were judged more emotional than vocalizations to infants out of view. Moreover, mothers smiled considerably more while singing than while speaking to infants. Experiment 2 examined the influence of video feedback from infants on maternal speech and singing. Maternal vocalizations in the context of video feedback were judged to be less emotional than those in face‐to‐face contexts but more emotional than those in out‐of‐view contexts. Experiment 3 compared six‐month‐old infants’ attention to maternal speech and singing with audio‐only versions or with silent video‐only versions. Infants exhibited comparable attention to audio‐only versions of speech and singing but greater attention to video‐only versions of singing. The present investigation is unique in documenting the contribution of infant visual feedback to maternal vocal emotion in contexts that control for infants’ presence, visibility, and proximity.     

The Effects of the Specialist Schools Education Policy on School and Post‐School Outcomes in England

We investigate the effects of the specialist schools policy, introduced in 1994 in England, on test scores and truancy for pupils during compulsory schooling. We also assess the effects on labour market status and post‐secondary test score performance. We use matching models and data from the Youth Cohort Surveys for pupils who left school in either 2002 or 2004. We find that the policy did raise test scores, as well as increase the probability of employment. The evidence on post‐secondary test scores is mixed insofar as the policy increased the number of A levels studied but reduced average points scores.     

Between exclusion and colonisation: seeking a place for mad people’s knowledge in academia

The omnipresent psychiatric narrative of mental illness has always had its counter-narrative – the life stories of people labelled mad. The relationship between these two accounts has always been one of domination: mad voices have been – and continue to be – not heard, overwritten, silenced or even erased in the course of psychiatric treatment. As survivor researchers who have had these kinds of experiences, we wish to discuss parallels between this tradition and some contemporary academic efforts that claim to disrupt it.     

Schengen's Soft Underbelly? Irregular Migration and Human Smuggling across Land and Sea Borders to Italy

La migration illégale à destination de l'Italie ou passant par ce pays est généralement associée dans l'esprit des gens à l'image de centaines, voire de milliers de migrants traversant la Méditerranée entassés dans de vieux rafiots se maintenant tout juste à flot. On considère souvent que les traversées de ce type sont la preuve de l'existence de cartels criminels qui seraient structurés hiérarchiquement, centralisés, extrêmement bien organisés et actifs au niveau mondial. Le seul problème avec de telles idées reçues est qu'elles ne concordent absolument pas avec les faits dont on dispose et n'ont pas grand chose à voir avec la réalité concrète des systèmes de migration illégale. Cette étude passe en revue un certain nombre de dossiers de tribunaux italiens concernant diverses organisations qui opèrent aussi bien au travers des frontières terrestres que maritimes. Elle montre comment de telles organisations opèrent en tenant compte de diverses spécificités locales et contraintes structurelles.