Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study

Purpose: To investigate a possible relation between penile Doppler ultrasound examination (PDUE) parameters and efficacy of chronic therapy with tadalafil (TAD) combined with a protocol of aerobic physical activity (PA) in patients with late onset hypogonadism (LOH). Methods: The study evaluated 30 patients consecutively enrolled with LOH and erectile dysfunction which present contraindication to hormonal replacement therapy for concomitant prostate disease. These patients were subjected to a combined protocol with phosphodiesterase V selective inhibitors (TAD 5?mg daily) and aerobic PA.

Results: After three months, we observed significant improvements in erectile function [IIEF-5, median (IQR)?=?13.0 (7.0–18.0) versus 6.0 (5.0–6.75); p?p?Conclusion: PA in association with phosphodiesterase V inhibitors could compensate the effects of hypogonadism on erectile function and facilitate the clinical response to these drugs even in the absence of adequate serum concentrations of total testosterone.     

The role of prosody in infants’ preference for speech: A comparison between speech and birdsong

Speech preferences emerge very early in infancy, pointing to a special status for speech in auditory processing and a crucial role of prosody in driving infant preferences. Recent theoretical models suggest that infant auditory perception may initially encompass a broad range of human and nonhuman vocalizations, then tune in to relevant sounds for the acquisition of species‐specific communication sounds. However, little is known about sound properties eliciting infants’ tuning‐in to speech. To address this issue, we presented a group of 4‐month‐olds with segments of non‐native speech (Mandarin Chinese) and birdsong, a nonhuman vocalization that shares some prosodic components with speech. A second group of infants was presented with the same segment of birdsong paired with Mandarin played in reverse. Infants showed an overall preference for birdsong over non‐native speech. Moreover, infants in the Backward condition preferred birdsong over backward speech whereas infants in the Forward condition did not show clear preference. These results confirm the prominent role of prosody in early auditory processing and suggest that infants’ preferences may privilege communicative vocalizations featured by certain prosodic dimensions regardless of the biological source of the sound, human or nonhuman.     

Unit Root Tests under Time-Varying Variances

The paper provides a general framework for investigating the effects of permanent changes in the variance of the errors of an autoregressive process on unit root tests. Such a framework - which is based on a novel asymptotic theory for integrated and near integrated processes with heteroskedastic errors - allows to evaluate how the variance dynamics affect the size and the power function of unit root tests. Contrary to previous studies, it is shown that non-constant variances can both inflate and deflate the rejection frequency of the commonly used unit root tests, both under the null and under the alternative, with early negative and late positive variance changes having the strongest impact on size and power. It is also shown that shifts smoothed across the sample have smaller impacts than shifts occurring as a single abrupt jump, while periodic variances have a negligible effect even when a small number of cycles take place over a given sample. Finally, it is proved that the locally best invariant (LBI) test of a unit root against level stationarity is robust to heteroskedasticity of any form under the null hypothesis.     

Correlates of internal audit function involvement in sustainability audits

Journal of Management and Governance - While an increasing number of organizations are engaging in sustainability activities, assurance of these activities is relatively new. We investigate the...     

Who knows what? Reconfiguring the governance and the capabilities of the supply chain between physical and digital processes in the fashion industry

Abstract

On the basis of an exploratory multiple-case qualitative longitudinal study in the fashion industry, this article describes how digital technologies enabled choices among different types of supply chain governance. In doing so, this study responds to calls for governance-oriented longitudinal explorations and suggests an alternative path of governance choices in which the digital technologies become the platform that allows a dynamic discourse between outsourcer and outsourcee. Our results show that, when firms decide to leverage their performances through the adoption of information technology, they need to define their knowledge transfer capacities in order to adopt the appropriate type of governance model. With this article, we contribute to the global value chain literature adding to the knowledge transfer dimension.     

The management of firms’ alliance network positioning: Implications for innovation

In spite of the frequent calls for a much more integrated approach, the field of management still faces the ever continuing challenges in attempting to bridge the gap between academic research and managerial actions and practices. The field of strategic alliances and firms’ networks are those among which research and practice are more diverging. Trying to cover this separation, the article presents an empirical research on automotive industry that investigates the effects on innovation performance of the position that firms occupy in the network of alliances. The hypothesis that guides this research is that innovation is generated not only from the resources that a company is able to develop internally, but also through access to resources and capabilities owned by the external companies and organizations that the firm itself is tied to through alliances and cooperation agreements. Beyond this broad argument, the paper links tightly research and practice showing way and how the quality of access to resources owned by partners is influenced by the position occupied in the network of alliances and not only by the existence of single collaborative ties. Assuming a managerial approach which relies on the milestones of network research, different types of positioning in the network of alliances are discussed and tested on their impact on innovation.     

Inhabitants' and Experts' Assessments of Environmental Quality for Urban Sustainability

In the context of sustainable urban development, we discuss the assessment of residential environmental quality and the importance of considering inhabitants' perceptions of natural resources in urban areas. Two series of studies, conducted in Guildford (United Kingdom) and in Rome (Italy), addressed the correspondence, or contrast, between inhabitants' and experts' assessment of urban quality concerning two crucial natural resources: air quality and biodiversity. The Guildford study emphasized the accuracy of the assessment of urban air quality by experts and the public. The Rome study focused on the evaluative criteria employed by scientists and the public in assessing the quality of urban green spaces. The results from both studies shed more, albeit complex, light on the simple conventional wisdom about public versus expert understanding and assessment of environmental quality. Study implications are discussed for the support of programs, methods, and tools for urban development, particularly with regard to effective communication and better structuring of residents' participation in urban environmental decision making.     

Development and Validation of a Democratic System Justification Scale

Social Indicators Research - Social psychologists have explored the multiple forms of status quo legitimization mainly in regard to the social and economic system. This study aimed to explore the...