城市年轻母亲育儿感受与育儿支援——基于北京与南京4所幼儿园的调查研究

本研究运用调查分析的方法了解大城市年轻母亲在育儿过程中的感受。研究发现,夫妻共同分担家庭育儿责任的观念深入人心,母亲在孩子成长中的重要性也得到肯定。养育孩子使年轻的母亲既充满了快乐和幸福,也伴随着各种不安和焦虑;她们普遍感到育儿支援存在缺陷,以至于难以从容面对育儿过程,希望能够获得比较充裕的社会资源,有一个良好的社会支持网络,帮助她们顺利完成育儿过程。为此建议,政府应制定相应的政策法规,提供一定的资金支持,加强对处于育儿期家庭的人文关怀;进一步强化男女平等意识,促进父亲更多地参与日常育儿活动;建立网上支援系统;改善城市规划建设,为育儿提供更好的空间环境。     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

伸展构造背景下倾角资料的构造解释

系统总结了在伸展构造背景下，导致反映构造特征的地层倾角模式复杂化的多种因素。沉积相的不同、岩性变化、井眼状况和测井作业时间等多种因素都可能使地层倾角资料复杂化。进一步指出在拉张盆地中，进行倾角资料的构造解释，必须了解其构造样式的多样性和复杂性，解释存在的多解性。重点解剖了铲式断层在横剖面情况下，对于不同构造位置下的倾角模式。详细分析了一个倾角模式对应多种构造样式的倾角构造解释实例。倾角资料的构造解释应是综合解释，既要综合井筒的相关地质资料，又要综合测井与地质知识，还必须考虑综合地震资料。     

如何促进产业集群发展?——美国亚利桑那州产业集群发展模式分析

1980年代末至1990年代初,美国亚利桑那州经济遭遇严重衰退,地区经济发展面临转型压力。1992年,亚利桑那州实施了产业集群战略,成功推动了地区经济的复苏和转型,并使其成为之后十余年美国经济增长最快的地区之一。通过对亚利桑那州产业集群战略的制定、调整和集群发展特征的深入分析发现,亚利桑那州产业集群的发展得益于科学的战略设计和以"技术密集型中小企业+企业网络组织"为双驱动的发展模式,而政府在这一过程中只扮演着"组织者"和"协调者"的角色。这对中国产业集群的发展具有重要的借鉴意义。     

自杀和生命的意义——来自脑科学研究的解读

生命本身是一个随机事件，并不具有高尚的意义。进化的结果使人类可通过工作、家庭和人际关系等给予自己的生命以意义感。当我们的生活方式使脑内奖赏系统获得刺激，就会带来生命具有意义的感受，这种感受给人带来更好的生存机会。生存的欲望是一切生物体最具特征的属性，一些精神疾病患者缺乏这种欲望。自杀主要发生于精神疾病患者，它并非是基于自由意志的行为。抗精神病治疗和适当的社会交往可以预防自杀。由于不同个体有着不同的大脑，人们的生活方式就应该去适应各自大脑的特征。只要人们的生活方式不对他人造成过多的伤害，政府就应该允许和保护人们自由地按照各自的方式生活。     

Changing Frameworks in Attitudes Toward Abortion

For more than two decades, legal abortion has been the subject of heated political debate and adversarial social movement activity; however, national polls have shown little change in aggregate levels of support for abortion. This analysis examines how the determinants of abortion attitudes have changed between 1977 and 1996, using data from the General Social Surveys. While in early time periods, whites were more approving of abortion than blacks, that pattern had reversed by the late 1980s. After controlling for other factors, older people are more accepting of abortion throughout the two decades, while gender is generally unrelated to abortion views. Catholic religion weakens slightly as a predictor of abortion attitudes, while religious fundamentalism and political liberalism increase in explanatory power. The associations between attitudinal correlates and abortion approval also change over this time period. Religiosity becomes a less powerful predictor of abortion attitudes, while respondents' attitude toward sexual freedom and belief in the sanctity of human life increase in their predictive power. Support for gender inequality remains a weak but stable predictor of abortion attitudes. This pattern of results suggests that the public is influenced more by the pro-life framework of viewing abortion than by the pro-choice perspective.     

Hidden Resources and Barriers in Career Learning Assessment With Adolescents Vulnerable to Discrimination

The authors maintain that the social learning theory of career development and counseling has not been applied to diverse populations. To address this gap in the literature, the authors conducted a qualitative analysis of interviews with 21 middle school students in a low‐income, culturally diverse, inner‐city public school. Four themes emerged, reflecting the influence of discrimination on participants' career learning: contextual barriers and resources for learning, and psychological barriers and resources for learning. The authors provide a conceptual framework for assessing resources and barriers and a rationale for why these aspects often remain hidden or unexamined in career assessment with clients who are vulnerable to discrimination.