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Hans Jørgen Rasmusen 《Omega》1974,2(2):243-251
This paper presents a multigoal linear programming model designed to analyse the impact of different strategic objectives in the planning of hospitals. The paper argues that it is necessary to adopt an overall point-of-view in planning; that it is necessary to consider the interactions between the hospital, other social and health institutions and the community at large in order to attain an efficient plan. A simplified cost-benefit analysis is suggested, and it is demonstrated that the opportunity costs of lost working days may be more important than both capital and operating costs from a social point of view. 相似文献
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The behaviour of the dynamic stochastic approximation algorithm suggested by DUPA[Cbreve] [4, 5] is examined under various conditions. Essentially, convergence in q.m. is proved and the rate of convergence is obtained for three classes of regression functions. Necessary and sufficient conditions are established for the convergence in q.m. of the algorithm in terms of the algorithm parameters for the stationary (nondynamic) case. 相似文献
65.
Sample size reestimation in a crossover, bioequivalence study can be a useful adaptive design tool, particularly when the intrasubject variability of the drug formulation under investigation is not well understood. When sample size reestimation is done based on an interim estimate of the intrasubject variability and bioequivalence is tested using the pooled estimate of intrasubject variability, type 1 error inflation will occur. Type 1 error inflation is caused by the pooled estimate being a biased estimator of the intrasubject variability. The type 1 error inflation and bias of the pooled estimator of variability are well characterized in the setting of a two‐arm, parallel study. The purpose of this work is to extend this characterization to the setting of a crossover, bioequivalence study with sample size reestimation and to propose an estimator of the intrasubject variability that will prevent type 1 error inflation. 相似文献
66.
Sanne te Meerman Laura Batstra Justin E. Freedman Rink Hoekstra Hans Grietens 《Children & Society》2020,34(2):136-150
Studies of brain size of children classified with ADHD appear to reveal smaller brains when compared to ‘normal’ children. Yet, what does this mean? Even with the use of rigorously screened case and control groups, these studies show only small, average group differences between children with and without an ADHD classification. However, academic textbooks used in the Netherlands often portray individual children with an ADHD classification as having a different, malfunctioning brain that necessitates medical intervention. This conceptualisation of ADHD might serve professional interests, but not necessarily the interests of children. 相似文献
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If we express our knowledge in sentences, we will find that these sentences are linked in complex patterns governed by our observations and our inferences from these observations. These inferences are to a large extent driven by logical rules. We ask whether the structure logic imposes on our knowledge restricts what we forget and what we remember. The model is a two period S5 logic. In this logic, we propose a memory loss operator: the agent forgets a sentence pif and only if he knows pat time 1 and he does not know pat time 2. Equipped with the operator, we prove theorems on the relation between knowledge and memory loss. The main results point to classes of formulas that an agent cannot forget, and classes of formulas he must forget. A desirable feature is that most results hold in the S4 logic. The results illustrate bounds to memory loss, and thus to bounded rationality. We apply the model to single-agent conventions: conventions made between an agent and himself. 相似文献
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When offering a product that has a complementary product in a different market, a firm must consider the interdependence between the complementary products as well as the competition within markets. If the firm participates in both markets, the balancing act becomes even more challenging. This article provides insights about strategies in this latter setting: when should the firm seek to keep its products closed to competing complementary products, and when would the firm be better off by accepting a common standard? To address these questions, we employ standard game theoretic analysis to a simple spatial model that captures aspects of both intermarket externalities and intramarket competition. We find that if a firm participates in both markets and chooses a closed standard, it achieves lower profits compared to an open standard, but gains greater market share. Surprisingly, we find that customers are better off when standards are kept closed. 相似文献