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121.
The term ‘land grabbing’ has recently attracted widespread, and sometimes agitated, attention, and its literature grows at exponential speed. At the same time, the concept remains little understood concerning both its meaning, magnitude and consequences and even who the grabbers are. Different attempts to define land grabbing appear to reflect ideological lenses and pre‐defined positions rather than a genuine ambition to find out what is actually going on. Based on a comprehensive literature review, this article aims at presenting a more nuanced understanding of this disputed topic and therefore a less biased account of what land‐grabbing and/or private investments in land represent.  相似文献   
122.
Increasing immigration is often linked with the public pressure for lower levels of publicly funded social expenditures. However, the empirical evidence on the effects of increasing immigration on social expenditures is discordant and depends on which countries are studied. This article argues that the employability of new immigrants as well as their entitlement to public benefits explains the observed impacts of immigration on social expenditures. Moreover, these same features can help to explain the increasing stringency of immigration policies.  相似文献   
123.
A gap exists between empirical evidence demonstrating the risks posed by domestic violence (DV) and the weight that evidence is given by custody evaluators. This gap may result from common beliefs about DV that diminish or deny its seriousness, which include that mothers often make false allegations to gain advantage and that DV and high conflict are synonymous and do not require differential approaches. Using a multiple segment factorial vignette design, we systematically assessed how these beliefs influenced custody evaluators' (N = 603) recommendations and judgments of the believability of allegations. Mother's demeanor (i.e., hostile vs. pleasant) was the most consistent predictor of evaluators' recommendations and judgments of credibility. Findings have implications for providing research-based education and training for evaluators.  相似文献   
124.
This paper considers the maximin approach for designing clinical studies. A maximin efficient design maximizes the smallest efficiency when compared with a standard design, as the parameters vary in a specified subset of the parameter space. To specify this subset of parameters in a real situation, a four‐step procedure using elicitation based on expert opinions is proposed. Further, we describe why and how we extend the initially chosen subset of parameters to a much larger set in our procedure. By this procedure, the maximin approach becomes feasible for dose‐finding studies. Maximin efficient designs have shown to be numerically difficult to construct. However, a new algorithm, the H‐algorithm, considerably simplifies the construction of these designs. We exemplify the maximin efficient approach by considering a sigmoid Emax model describing a dose–response relationship and compare inferential precision with that obtained when using a uniform design. The design obtained is shown to be at least 15% more efficient than the uniform design. © 2014 The Authors. Pharmaceutical Statistics Published by John Wiley & Sons Ltd.  相似文献   
125.
126.
T-cell engagers are a class of oncology drugs which engage T-cells to initiate immune response against malignant cells. T-cell engagers have features that are unlike prior classes of oncology drugs (e.g., chemotherapies or targeted therapies), because (1) starting dose level often must be conservative due to immune-related side effects such as cytokine release syndrome (CRS); (2) dose level can usually be safely titrated higher as a result of subject's immune system adaptation after first exposure to lower dose; and (3) due to preventive management of CRS, these safety events rarely worsen to become dose limiting toxicities (DLTs). It is generally believed that for T-cell engagers the dose intensity of the starting dose and the peak dose intensity both correlate with improved efficacy. Existing dose finding methodologies are not designed to efficiently identify both the initial starting dose and peak dose intensity in a single trial. In this study, we propose a new trial design, dose intra-subject escalation to an event (DIETE) design, that can (1) estimate the maximum tolerated initial dose level (MTD1); and (2) incorporate systematic intra-subject dose-escalation to estimate the maximum tolerated dose level subsequent to adaptation induced by the initial dose level (MTD2) with a survival analysis approach. We compare our framework to similar methodologies and evaluate their key operating characteristics.  相似文献   
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128.
We test a structural equations model of stigma against tattooed persons and attitudes toward future tattoos among 195 tattooed and 257 non-tattooed college students. Having tattooed friends and family members undermines stigma against tattooed persons while beliefs about negative side effects of tattooing reinforces stigma assignment. The variables above and the respondent having a tattoo predict attitude toward future tattoos. We test a second model, stigma victimization, drawing on data from the 195 tattooed respondents. While greater tattoo abundance results in greater stigma victimization, respondents with more tattoos also report a greater commitment to their current tattoos and less desire for removal. We discuss results using attitude theory, stigma theory, and the contact theory of prejudice.  相似文献   
129.
This article analyses how cultural patterns and social organization shape the meaning-making of human mobility and technology, and vice versa. We extend the definition of mobile technologies from engineered devices with portable quality to tools supporting peoples’ customary mobile practices. Specifically, we analyse the embodiment of contemporary mobile technologies into Maasai culture. Mobile practices have socio-cultural, economic and political meanings. The very fabric of the culture through which mobile practices are negotiated here is cattle. In focus are the mobilities shaping Maasailand. We argue that, rather than causing radical cultural change, novel mobile technologies are embedded, rationalized and re-purposed. Furthermore, a local-to-global cooperation on indigenous rights is facilitated.  相似文献   
130.
Incomplete preferences over lotteries on a finite set of alternatives satisfying, besides independence and continuity, a property called bad outcome aversion are considered. These preferences are characterized in terms of their specific multi-expected utility representations (cf. Dubra et al., J Econ Theory, 115:118–133, 2004), and can be seen as generalized stochastic dominance preferences.  相似文献   
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