Could Removing Arsenic from Tobacco Smoke Significantly Reduce Smoker Risks of Lung Cancer?

If a specific biological mechanism could be determined by which a carcinogen increases lung cancer risk, how might this knowledge be used to improve risk assessment? To explore this issue, we assume (perhaps incorrectly) that arsenic in cigarette smoke increases lung cancer risk by hypermethylating the promoter region of gene p16INK4a, leading to a more rapid entry of altered (initiated) cells into a clonal expansion phase. The potential impact on lung cancer of removing arsenic is then quantified using a three‐stage version of a multistage clonal expansion (MSCE) model. This refines the usual two‐stage clonal expansion (TSCE) model of carcinogenesis by resolving its intermediate or “initiated” cell compartment into two subcompartments, representing experimentally observed “patch” and “field” cells. This refinement allows p16 methylation effects to be represented as speeding transitions of cells from the patch state to the clonally expanding field state. Given these assumptions, removing arsenic might greatly reduce the number of nonsmall cell lung cancer cells (NSCLCs) produced in smokers, by up to two‐thirds, depending on the fraction (between 0 and 1) of the smoking‐induced increase in the patch‐to‐field transition rate prevented if arsenic were removed. At present, this fraction is unknown (and could be as low as zero), but the possibility that it could be high (close to 1) cannot be ruled out without further data.     

SELF-CONTROL,POLITICAL IDEOLOGY,AND MISBEHAVIOR: UNPACKING THE EFFECTS OF CONSERVATIVE IDENTITY

Survey data collected from a southwestern metropolitan area indicate that self-defined politically conservative individuals are less inclined to commit criminal or deviant acts than their liberal or moderate counterparts; however, results from multivariate analyses indicate that measures of self-control and pressure to conform all reduce the effects of political conservatism to nonsignificance. In general, the relationship between political ideology and misbehavior appears to be partly spurious and partly indirectly attributable to the effects of other social and situational factors. Moreover, responsiveness to pressures to conform is not due to self-control. The results provide some challenge to traditional interpretations of misbehavior but they also confirm an important part played by structural/contextual variables.     

Into the divide: community identities and the visualisation of place

This article discusses the experience of place in a profoundly divided urban area of Sheffield. At a time when the gap between affluence and poverty has reached its widest point since the 1960s, this article explores the relationship between individuals and their sense of place and of the trenchant divisions separating communities. The study employs various methods but centres upon the use of hand-drawn maps; creating a dialogue between the interviewers and a number of local residents. These maps and the accompanying commentaries demonstrate the diverse individual sense of a particular place and a dialectical sense of space. The resulting picture is one of both the persistence of historical divisions, suggesting regulation and control through planning and policing, but also of complex entanglements of social identities, habitus and place which defy easy categorisation.     

The fusion of culture and science: Challenges and controversies of cultural competency and evidence-based practice with an African American family advocacy network

This paper identifies interrelationships between evidence-based practice (EBP), radical structuralism, and culture, arguing that culturally-specific beliefs and norms should be integrated into evidence-based, cross-cultural partnerships within child and family service systems. A single case study of family advocate training in evidence-based practice is provided as an illustration of, and impetus for, the development of a format for use with community-based and ethnically-diverse parent/family advocates. The lessons learned from teaching evidence-based practice to a parent advocate in a particular child welfare service system are highlighted. The use of enhanced roles for social workers and indigenous social capital and resources, such as family advocates as allies, is recommended to help achieve a greater degree of accountability, cooperation, and core understanding in the use of EBP. By training racially-diverse foster parents as mental health advocates to work collaboratively with policymakers, community groups, and family participants, proponents of EBP will reach and benefit more diverse populations.     

The structure of employee attitudes to safety: A European example

This paper concerns organizational safety culture and the structure or architecture of employee attitudes to safety as part of that culture. It begins by reviewing the somewhat scant literature relevant to this area, and then reports a study, conducted in a European company, which collected and factor analysed data on employee attitudes to safety. The framework provided for the study was that offered by Purdham (1984), and the results suggested that employees' attitudes to safety, within this company (across occupation/occupational level and country), could be mapped By five orthogonal factors: personal scepticism, individual responsibility, the safeness of the work environment, the effectiveness of arrangements for safety, and personal immunity. The theoretical and practical implications of these findings are discussed, and attention is drawn to their subsequent use in an intervention to enhance safety culture within the organization by attacking supervisors' attitudes to safety.     

A Methodology for Seismic Risk Analysis of Nuclear Power Plants

This methodology begins by quantifying the fragility of all key components and structures in the plant. By means of the logic encoded in the plant event trees and fault trees, the component fragilities are combined to form fragilities for the occurrence of plant damage states or release categories. Combining these, in turn, with the seismicity curves yields the frequencies of those states or releases. Uncertainty is explicitly included at each step of the process.     

Child maltreatment in families experiencing domestic violence

This study examined the association between physical domestic violence (PDV) and reported child maltreatment in a cohort of children at risk for maltreatment. Participants were 219 6- to 7-year-old children and their caregivers. PDV was measured by combining caregivers' self-reports and children's reports, while child maltreatment was based on state Division of Social Services Central Registry records. Among 219 child-caregiver pairs studied, 42 (19.2%) had at least one maltreatment report in the 2 years following the interviews. PDV consistently predicted child maltreatment, with adjusted odds ratios ranging from 2.96 to 3.46. In addition, we investigated interactions between PDV and other predictors of child maltreatment. Among Aid to Families with Dependent Children (AFDC) participants, PDV was highly associated with child maltreatment. However, this pattern was not observed among subjects who did not have AFDC. There is an increased incidence of child maltreatment reports in families experiencing PDV. AFDC participation intensified the probability of child maltreatment in the presence of PDV. Findings also suggest that in households experiencing PDV, social supports may protect children from maltreatment.     

Procedures for improving the mle for ordered binomial parameters

The problem is that of estimating the probabilities of m independent binomial random variables when their probabilities are known to be nondecreasing and the loss function is squared error. In the cases where the m.l.e. is inadmissible (essentially when the total number of trials is 7 or more) we present a method for modifying the m.l.e. to get a better estimator. The method requires a series of changes. At each step we alter the action taken by the m.l.e. on each of three, appropriately chosen, points in the sample space.