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191.
T. Jaki A. Gordon P. Forster L. Bijnens B. Bornkamp W. Brannath R. Fontana M. Gasparini L.V. Hampson T. Jacobs B. Jones X. Paoletti M. Posch A. Titman R. Vonk F. Koenig 《Pharmaceutical statistics》2018,17(5):593-606
This paper provides an overview of “Improving Design, Evaluation and Analysis of early drug development Studies” (IDEAS), a European Commission–funded network bringing together leading academic institutions and small‐ to large‐sized pharmaceutical companies to train a cohort of graduate‐level medical statisticians. The network is composed of a diverse mix of public and private sector partners spread across Europe, which will host 14 early‐stage researchers for 36 months. IDEAS training activities are composed of a well‐rounded mixture of specialist methodological components and generic transferable skills. Particular attention is paid to fostering collaborations between researchers and supervisors, which span academia and the private sector. Within this paper, we review existing medical statistics programmes (MSc and PhD) and highlight the training they provide on skills relevant to drug development. Motivated by this review and our experiences with the IDEAS project, we propose a concept for a joint, harmonised European PhD programme to train statisticians in quantitative methods for drug development. 相似文献
192.
This study compares different strategies for arranging machines in a facility. Computer simulation of two different machine shops was used to compare process layout (the arrangement of groups of machines where the machines within a group are interchangeable) to cellular layout designed using group technology concepts (the use of manufacturing cells where each cell contains different types of machines dedicated to the production of similar parts). Four layout strategies, including process layout, cellular layout, and two hybrid layouts, were compared in two machine-shop models. The shops that used cellular layouts had shorter setup times, lower machine utilization, and shorter distances traveled, on average. The shops with process layout, however, had better performance on queue-related statistics such as work-in-process inventory level and average flow time. This suggests that a well-organized traditional job shop may be able to achieve overall performance that at least is comparable to that of the same shop using cellular (group technology) layout. 相似文献
193.
Clifford L. Broman Myriam Torres Renee B. Canady Harold W. Neighbors James S. Jackson 《Race and social problems》2010,2(2):81-91
We examine if commonly used distress measures, rates of psychiatric disorders, and chronic health conditions are affected
by alternate measures of race-ethnicity for African Americans and Caribbean blacks. We examined two alternative self-identification
measures to investigate if their influence might differ. A study on national household probability sample of non-institutionalized
African Americans (n = 3,570) and blacks from Caribbean countries, who now live in the United States (n = 1,621), was conducted between February 2001 and June 2003, using a slightly modified version of the Composite International
Diagnostic Interview. The method used to measure black race and ethnicity has influence on physical and mental health outcomes.
The distributions of depressive symptoms are not affected, while the distributions of DSM IV disorders and chronic health
conditions vary by race and ethnic self-identifications among the African American and Caribbean black populations. There
are serious implications of using alternate measures of race-ethnicity on the distribution of physical and mental health morbidity
among African Americans and Caribbean blacks. The conceptualization and assessment of race-ethnicity should be carefully considered
when studying mental and physical health statuses and service needs in the American black population. 相似文献
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195.
Shaw L Jacobs K Rudman D Magalhaes L Huot S Prodinger B Mandich A Hocking C Akande V Backman C Bossers A Bragg M Bryson M Cowls J Stone SD Dawe E Dennhardt S Dennis D Foster J Friesen M Galheigo S Gichuri J Hughes I Isaac A Jarus T Kinsella A Klinger L Leyshon R Lysaght R McKay E Orchard T Phelan S Ravenek M Rebeiro Gruhl K Robb L Stadnyk R Sumsion T Suto M 《Work (Reading, Mass.)》2012,41(4):369-377
196.
This investigation assesses the relationships between racial threat and partisan dominance in state legislatures with tests of interactive hypotheses. The findings show that historically contingent expectations derived from racial threat theory, Republican law and order campaign appeals, and fundamentalist strength account for Republican strength in the legislatures. Two-way fixed-effects estimates based on pooled time-series analyses of 799 state-years in the post-civil rights era show that the percentage of Republicans in the state legislatures grew after increases in African American presence and the violent crime rates. The combined effects of a growth in African American and fundamentalist populations also account for increased Republican seats in these bodies. Statements by Republican campaign officials on how they deliberately used mass resentments against minorities to gain votes provide evidence about the intervening links between minority threat, the menace posed by high violent crime rates, and increased Republican strength in the state legislatures. 相似文献
197.
Harold H. Gardner Nathan L. Kleinman Richard J. Butler 《Journal of Risk and Uncertainty》2000,20(1):89-112
At $60 billion per year, the workers' compensation system has come under increased scrutiny as firms, insurers, and researchers study the dynamics of claim filing. The Family and Medical Leave Act also covers most workers, and there has been very little research concerning the effects of FMLA legislation on employment. One hitherto neglected research area in both workers' compensation and FMLA is claim contagion. That is, as a claim is filed within a workgroup, does this increase the likelihood that others within the same workgroup will also file claims? We find the answer to be yes. We also find that this contagion effect is subject to diminishing returns to scale, however, in the sense that the claims probability increases at a decreasing rate as fellow employees' claims frequency increases. We argue that this is consistent with a model in which workers learn about filing a workers' compensation or FMLA claim from other workers. 相似文献
198.
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200.
This article compares the functionalist and behaviorist approachesto mass communications research and examines their respectivepolicy-making implications and limitations. 相似文献