Who cares about consent requirements for sourcing human embryonic stem cells? Are errors in the past really errors of the past?

Through an Access to Information Act request, we have obtained the consent forms used by the providers of every human embryonic stem cell (hESC) line approved for use by the Canadian Institutes of Health Research (CIHR), and examined them to verify whether or not they meet the consent requirements established by Canadian law and regulations. Our findings show that at least seven out of ten consent forms studied did not satisfy these minimum requirements. We then outline various options for responding to this situation in terms of: (i) remedial measures for dealing with executive problems with regulatory oversight procedures; and (ii) remedial measures for dealing with the impugned lines.     

Tissue Dosimetry, Pharmacokinetic Modeling, and Interspecies Scaling Factors

Interspecies scaling factors (ISFs) are numbers used to adjust the potency factor (for example, the q1* for carcinogens or reference doses for compounds eliciting other toxic endpoints) determined in experimental animals to account for expected differences in potency between test animals and people. ISFs have been developed for both cancer and non-cancer risk assessments in response to a common issue: toxicologists often determine adverse effects of chemicals in test animals and then they, or more commonly risk assessors and risk managers, have to draw inferences about what these observations mean for the human population. This perspective briefly reviews the development of ISFs and their applications in health risk assessments over the past 20 years, examining the impact of pharmacokinetic principles in altering current perceptions of the ISFs applied in these health risk assessments, and assessing future directions in applying both pharmacokinetic and pharmacodynamic principles for developing ISFs.     

Decision-making in the public sector- a logical model

The decision making process consists of three basic elements. These factors are goals and standards, personality, and environment. Given these three concepts, the decision maker in the public sector follows identifiable processes. Some of these processes are more valuable and yield better results than others. This work is an attempt to discuss this process after an overview of the subject and to identify a model which will facilitate the decision making procedure.     

Consumer racial discrimination: A reassessment of the market for baseball cards

Research on the presence of consumer racial discrimination in the baseball labor and memorabilia markets has produced contradictory empirical results. While studies of baseball salaries find no evidence of discrimination, Nardinelli and Simon (1990) and Andersen and La Croix (1991) use data from the baseball card market to show that the price that consumers pay for a card depends on the player’s race. In this paper, we reconsider the evidence of consumer discrimination in the baseball card market. Our study improves on previous research by applying more appropriate econometric methods and using a data set in which card supply is constant and incentives for speculative demand are weaker. In contradiction to the aforementioned studies, we find little evidence of racial discrimination. This result proves robust across variable specifications and econometric models. The authors thank Tyler Cowen, Kevin Grier, David Levy, Barb McKiernan, Don Palmer, Dan Sutler, and Bob Tollison for helpful suggestions on an earlier draft.     

Deviance,Rule-Breaking and Male Dominance in Conversation

Previous research on dyadic interaction indicates that cross-sex conversations (male-female) are characterized by more frequent interruptions than same-sex conversations. More specifically, males consistently tend to interrupt their female co-conversationalists. Survey data from three student samples suggest that normative definitions reflected in perceptions of interruption are inconsistent with the empirical distribution of rule-breaking observed by conversational researchers. These results provide some strategic insights into the problematic distinction between deviance and rule-breaking that has been central to labeling theory.     

Achieving the indeterminate: Accomplishing degrees of certainty in life and death situations

This paper explores technology's pivotal position at the intersection of control and uncertainty. It examines two areas: Intensive Care and a Labour Ward. Building on the work of Davis (1960), it argues that certainty and uncertainty are socially constructable and reconstructable. This is actively achieved by the deployment of strategies involving particular paradigms (the biomedical model) and artefacts (medical technology). Power lies in control over knowledge and the structures and practices which sustain it, including those embedded in advanced technology. The contribution of medical technology to the achievement of certainty in Intensive Care and end-game Obstetrics (the Labour Ward) is considered. Achieved certainty in medical situations is seen as: the structured masking of uncertainty by the application of medical iconography, artefacts and techniques to create the illusion of certainty. The accomplishment of uncertainty in Obstetrics (as a precursor to technological intervention) is also explored. The accomplishment of uncertainty in medical situations is seen as associated with the structured projection of uncertainty, involving using medical discourse rooted in the medical paradigm to exaggerate the generality of risk and the probability of pathology. It is argued that the highly structured and routinised settings of ICU and the labour Ward, not only aid control by the medical profession but diminish perceptions of uncertainty.