Global Environmental Change and Historical Transitions

What do transition processes in rural areas in Thailand, biomass consumption in nineteenth-century Austria and the ecology of hunter-gatherers have to do with the appropriation of plant production and global environmental change? More than one might think of in the first place. They are part of a scholarly discourse on our changing relations with the environment. We argue that global change can be analysed in terms of transitions between major modes of subsistence and try to document this with several case studies.     

Assessing goodness-of-fit for evaluation of dose-proportionality

For the clinical development of a new drug, the determination of dose-proportionality is an essential part of the pharmacokinetic evaluations, which may provide early indications of non-linear pharmacokinetics and may help to identify sub-populations with divergent clearances. Prior to making any conclusions regarding dose-proportionality, the goodness-of-fit of the model must be assessed to evaluate the model performance. We propose the use of simulation-based visual predictive checks to improve the validity of dose-proportionality conclusions for complex designs. We provide an illustrative example and include a table to facilitate review by regulatory authorities.     

Exactness and precision

Policy Delphi methods have not received the level of methodological scrutiny evidenced by more established techniques. This paper provides an examination of the potential for study participants to opt in/opt out of consecutive Delphi rounds. The literature proposes that this is a positive feature of the approach but evidence to support this position is lacking. This paper provides a brief review of the Policy Delphi method and than presents details of participation patterns in a study where the opt‐in/opt‐out option was available. Findings showed that participants exercised the option of opting in/opting out of different Delphi rounds. Although only 20.6% of the original participants completed all three Delphi rounds, the response rate (regardless of participants’ involvement in previous rounds) across all three Delphi rounds held fairly consistent at around 40%. These findings are significant as they relate to the need for an expanded repertoire of research tools that can address the complex, non‐linear questions emerging in post‐modern society.