Assessing efficacy in important subgroups in confirmatory trials: An example using Bayesian dynamic borrowing

Assessment of efficacy in important subgroups – such as those defined by sex, age, race and region – in confirmatory trials is typically performed using separate analysis of the specific subgroup. This ignores relevant information from the complementary subgroup. Bayesian dynamic borrowing uses an informative prior based on analysis of the complementary subgroup and a weak prior distribution centred on a mean of zero to construct a robust mixture prior. This combination of priors allows for dynamic borrowing of prior information; the analysis learns how much of the complementary subgroup prior information to borrow based on the consistency between the subgroup of interest and the complementary subgroup. A tipping point analysis can be carried out to identify how much prior weight needs to be placed on the complementary subgroup component of the robust mixture prior to establish efficacy in the subgroup of interest. An attractive feature of the tipping point analysis is that it enables the evidence from the source subgroup, the evidence from the target subgroup, and the combined evidence to be displayed alongside each other. This method is illustrated with an example trial in severe asthma where efficacy in the adolescent subgroup was assessed using a mixture prior combining an informative prior from the adult data in the same trial with a non-informative prior.     

Prosecution of women arrested for intimate partner abuse

Increasing arrests of women for domestic violence (DV) in the wake of mandatory arrest laws have generated significant concern among victim advocates, researchers, and practitioners. It is commonly believed that many, if not most, of the women arrested are victims who were acting in self-defense. Understanding how these cases are handled by prosecutors and judges is important if we wish to minimize the negative consequences of these errant arrests. The present study examines factors prosecutors in a large southern city considered when accepting or rejecting DV cases involving female defendants. The results indicate that almost one half (47%) of the cases involving women arrested for DV against a heterosexual intimate partner were rejected by prosecutors; another 16% were dismissed by a judge. Legal factors like a defendant's prior criminal arrests, use of a weapon, victim injury, and, most important, the type of arrest (i.e., dual vs. single arrest) all affected prosecutors' decisions to take these cases. Female defendants arrested for offending against a male intimate partner were treated more leniently than male defendants and women arrested for domestic offenses involving other types of relationships (i.e., familial, homosexual). The results highlight the need for a further study of officers' arrest decisions in cases involving heterosexual intimate partners.     

Disjunctive total domination in graphs

Let \(G\) be a graph with no isolated vertex. In this paper, we study a parameter that is a relaxation of arguably the most important domination parameter, namely the total domination number, \(\gamma _t(G)\). A set \(S\) of vertices in \(G\) is a disjunctive total dominating set of \(G\) if every vertex is adjacent to a vertex of \(S\) or has at least two vertices in \(S\) at distance \(2\) from it. The disjunctive total domination number, \(\gamma ^d_t(G)\), is the minimum cardinality of such a set. We observe that \(\gamma ^d_t(G) \le \gamma _t(G)\). We prove that if \(G\) is a connected graph of order \(n \ge 8\), then \(\gamma ^d_t(G) \le 2(n-1)/3\) and we characterize the extremal graphs. It is known that if \(G\) is a connected claw-free graph of order \(n\), then \(\gamma _t(G) \le 2n/3\) and this upper bound is tight for arbitrarily large \(n\). We show this upper bound can be improved significantly for the disjunctive total domination number. We show that if \(G\) is a connected claw-free graph of order \(n > 14\), then \(\gamma ^d_t(G) \le 4n/7\) and we characterize the graphs achieving equality in this bound.     

Epistemological inclusiveness in researching the African American community

Abstract

African American communities have experienced negative effects from a history of medical abuse, lack of proper research procedures, and misinterpretations of study findings because of racism. These past injustices have led to a mistrust of research and researchers. This paper focuses on how some methodological challenges, in a study funded by a National Institutes of Health grant on two low-income African American communities in Kentucky, were mediated through the collaboration of a multi-racial/ethnic team of researchers engaged in cross-disciplinary research. The information for this paper is based on the reflections of key members of the research team. The reflections show that having researchers with different epistemologies resulted in a culturally aware and sensitive study in which emic and etic research approaches were adopted. The inclusion of race-based epistemologies and close community ties were found to be particularly useful in building trust and getting the support of the two communities. However, these outcomes were only possible because research team members provided each other latitude for intellectual freedom and leadership.     

Magnetic Imagery: War‐Related Ribbons as Collective Display*

The collective display of particular symbols represents an emergent form of social movement participation. This study documents the patterns of the collective display of one such symbol; the magnetic war‐related ribbon (WRR). Using bivariate and multivariate analyses of a sample of 8,100 vehicles, we studied the relationships between WRR display and measures of political affiliation, patriotism, and war support. The results find that that WRR display is positively associated with affiliation with George W. Bush and the Republican Party, and various displays of patriotism and war support. This study demonstrates how advents in communication technologies, shifts in the social, economic, and political structures have converged and given rise to a new form of symbolic participation marked by the collective display of cause‐related symbols.     

Joseph Gusfield and Social Problems Theory

Joseph R. Gusfield was a key figure in the emergence of constructionist social problems theory. His approach was characterized by: his determination to identify the cultural, structural, and historical context of claims; attention to the choices among alternatives that shaped how problems were defined; and the rhetoric used by advocates. He highlighted the role of ownership–the ability to define the terms in which social problems are constructed. His work is also notable for its skepticism regarding social scientists’ theorizing.