Preparing individual patient data from clinical trials for sharing: the GlaxoSmithKline approach

In May 2013, GlaxoSmithKline (980 Great West Road, Brentford, Middlesex, TW8 9GS, UK) established a new online system to enable scientific researchers to request access to anonymised patient level clinical trial data. Providing access to individual patient data collected in clinical trials enables conduct of further research that may help advance medical science or improve patient care. In turn, this helps ensure that the data provided by research participants are used to maximum effect in the creation of new knowledge and understanding. However, when providing access to individual patient data, maintaining the privacy and confidentiality of research participants is critical. This article describes the approach we have taken to prepare data for sharing with other researchers in a way that minimises risk with respect to the privacy and confidentiality of research participants, ensures compliance with current data privacy legal requirements and yet retains utility of the anonymised datasets for research purposes. We recognise that there are different possible approaches and that broad consensus is needed. Copyright © 2014 John Wiley & Sons, Ltd.     

Promoting personalization in social care services for older people

This article presents findings on 4 themes associated with the personalization of social care for older people: integration of health and social care services; initiatives that prevent the need for more costly interventions; services to maintain people at home; and systems that promote choice, control, and flexibility. The quantitative study utilized data from a national postal survey conducted in England. Findings suggest variable progress regarding the range and style of support available to older people. These are discussed in the context of service integration, community-based services, and consumer-directed care. Implications for service development and future research are highlighted.     

A statistical framework for strategic decision making with AHP: Probability assessment and Bayesian revision

A probability assessment framework is outlined for an organizational decision involving a conditioning event (CE). The decision may, for example, involve a new-product launch (strategic decision) dependent on the outcome of market research (CE). The framework illustrates how Bayesian revision could be employed as related “news” arrives intermittently to revise current probabilities prior to decision implementation. A unique contribution of this paper is its utilization of the analytic hierarchy process to ascertain a set of consistent and coherent probabilities for the event/sample spaces at all stages of the decision process.     

‘You Feel Sad?’ Emotion Understanding Mediates Effects of Verbal Ability and Mother–Child Mutuality on Prosocial Behaviors: Findings from 2 Years to 4 Years

Early individual differences in prosocial behaviors are pivotal for children's peer relationships. To investigate the interplay among verbal ability, emotion understanding, and mother–child mutuality as predictors of prosocial behaviors, we observed 102 children at the ages of two, three, and four. All time points included verbal ability and emotion understanding tests and both video‐based and maternal ratings of prosocial behavior. The first two time points also included video‐based ratings of mother–child mutuality. The third time point included teacher ratings of prosocial behavior and an experimental task. Regression analysis demonstrated robust associations between emotion understanding at the age of three and prosocial behavior at the age of four. Path analysis showed that emotion understanding at the age of three mediated associations between verbal ability/mother–child mutuality at the age of two and prosocial behavior at the age of four.     

Global value chains for medical gloves during the COVID-19 pandemic: Confronting forced labour through public procurement and crisis

This paper evaluates ways in which labour issues in global value chains for medical gloves have been affected by, and addressed through, the COVID-19 pandemic. It focuses on production in Malaysia and supply to the United Kingdom's National Health Service and draws on a large-scale survey with workers and interviews with UK government officials, suppliers and buyers. Adopting a Global Value Chain (GVC) framework, the paper shows how forced labour endemic in the sector was exacerbated during the pandemic in the context of increased demand for gloves. Attempts at remediation are shown to operate through both a reconfigured value chain in which power shifted dramatically to the manufacturers and a context where public procurement became higher in profile than ever before. It is argued that the purchasing power of governments must be leveraged in ways that more meaningfully address labour issues, and that this must be part of value chain resilience.     

Effect of Trajectories of Friends' and Parents' School Involvement on Adolescents' Engagement and Achievement

In a sample of 527 academically at‐risk youth, we investigated trajectories of friends' and parents' school involvement across ages 12–14 and the joint contributions of these trajectories to adolescents' age 15 school engagement and academic achievement. Girls reported higher levels of friends' and parents' school involvement than boys. Both parents' and friends' school involvement declined across ages 12–14. Combined latent growth models and structural equation models showed effects of the trajectories of friends' and parents' school involvement on adolescents' age 15 school engagement and academic achievement, over and above adolescents' prior performance. These effects were additive rather than interactive. Strategies for enhancing parent involvement in school and students' affiliation with peers who are positively engaged in school are discussed.