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71.
Methods for exploring treatment effect heterogeneity in subgroup analysis: an application to global clinical trials
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Multi‐country randomised clinical trials (MRCTs) are common in the medical literature, and their interpretation has been the subject of extensive recent discussion. In many MRCTs, an evaluation of treatment effect homogeneity across countries or regions is conducted. Subgroup analysis principles require a significant test of interaction in order to claim heterogeneity of treatment effect across subgroups, such as countries in an MRCT. As clinical trials are typically underpowered for tests of interaction, overly optimistic expectations of treatment effect homogeneity can lead researchers, regulators and other stakeholders to over‐interpret apparent differences between subgroups even when heterogeneity tests are insignificant. In this paper, we consider some exploratory analysis tools to address this issue. We present three measures derived using the theory of order statistics, which can be used to understand the magnitude and the nature of the variation in treatment effects that can arise merely as an artefact of chance. These measures are not intended to replace a formal test of interaction but instead provide non‐inferential visual aids, which allow comparison of the observed and expected differences between regions or other subgroups and are a useful supplement to a formal test of interaction. We discuss how our methodology differs from recently published methods addressing the same issue. A case study of our approach is presented using data from the Study of Platelet Inhibition and Patient Outcomes (PLATO), which was a large cardiovascular MRCT that has been the subject of controversy in the literature. An R package is available that implements the proposed methods. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
72.
Ian C. Marschner 《Australian & New Zealand Journal of Statistics》2015,57(4):437-462
Relative risks are often considered preferable to odds ratios for quantifying the association between a predictor and a binary outcome. Relative risk regression is an alternative to logistic regression where the parameters are relative risks rather than odds ratios. It uses a log link binomial generalised linear model, or log‐binomial model, which requires parameter constraints to prevent probabilities from exceeding 1. This leads to numerical problems with standard approaches for finding the maximum likelihood estimate (MLE), such as Fisher scoring, and has motivated various non‐MLE approaches. In this paper we discuss the roles of the MLE and its main competitors for relative risk regression. It is argued that reliable alternatives to Fisher scoring mean that numerical issues are no longer a motivation for non‐MLE methods. Nonetheless, non‐MLE methods may be worthwhile for other reasons and we evaluate this possibility for alternatives within a class of quasi‐likelihood methods. The MLE obtained using a reliable computational method is recommended, but this approach requires bootstrapping when estimates are on the parameter space boundary. If convenience is paramount, then quasi‐likelihood estimation can be a good alternative, although parameter constraints may be violated. Sensitivity to model misspecification and outliers is also discussed along with recommendations and priorities for future research. 相似文献
73.
Can ranking techniques elicit robust values? 总被引:1,自引:0,他引:1
This paper reports two experiments which examine the use of ranking methods to elicit ‘certainty equivalent’ values. It investigates
whether such methods are able to eliminate the disparities between choice and value which constitute the ‘preference reversal
phenomenon’ and which thereby pose serious problems for both theory and policy application. The results show that ranking
methods are vulnerable to distorting effects of their own, but that when such effects are controlled for, the preference reversal
phenomenon, previously so strong and striking, is very considerably attenuated.
相似文献
Graham LoomesEmail: |
74.
Australian farms continue to suffer economic pressure which directly and indirectly produces stress among farm family members. This study uses qualitative and quantitative data to isolate factors which predict stress, Financial condition, perception of what is at stake, the combination of on-farm and off-farm obligations and the general frustrations of farm life are found to predict stress among both men and women. Gender relations and attachment to farm life emerge as stronger predictors for women, while youth is a stronger predictor for men. The study concludes that attempts to develop and preserve the family farm may be creating stressful situations which threaten the family relations upon which the farming system is based. 相似文献
75.
Theory and Society - 相似文献
76.
The investigation of multi-parameter likelihood functions is simplified if the log likelihood is quadratic near the maximum, as then normal approximations to the likelihood can be accurately used to obtain quantities such as likelihood regions. This paper proposes that data-based transformations of the parameters can be employed to make the log likelihood more quadratic, and illustrates the method with one of the simplest bivariate likelihoods, the normal two-parameter likelihood. 相似文献
77.
Doyo G. Enki Nickolay T. Trendafilov Ian T. Jolliffe 《Journal of applied statistics》2013,40(3):583-599
A new method for constructing interpretable principal components is proposed. The method first clusters the variables, and then interpretable (sparse) components are constructed from the correlation matrices of the clustered variables. For the first step of the method, a new weighted-variances method for clustering variables is proposed. It reflects the nature of the problem that the interpretable components should maximize the explained variance and thus provide sparse dimension reduction. An important feature of the new clustering procedure is that the optimal number of clusters (and components) can be determined in a non-subjective manner. The new method is illustrated using well-known simulated and real data sets. It clearly outperforms many existing methods for sparse principal component analysis in terms of both explained variance and sparseness. 相似文献
78.
Ian Bedford 《The Asia Pacific Journal of Anthropology》2013,14(1):70-87
Michael M.J. Fischer and Mehdi Abedi. Debating Muslims: cultural dialogue in postmodernity and tradition. Madison: University of Wisconsin Press. 1990. xxxvi, 564pp., plates, 3 appendices, chronology of events, notes, glossary, bibliography. $36.95 ISBN 0 299 12430 4 (hard), 0 299 12434 7 (paper). 相似文献
79.
When Ian Wilson and Carlos Barahona of the Statistical Services Centre at the University of Reading were asked to review an evaluation of the effectiveness of an aid package in Malawi, they expected a simple enough task. But few things in the developing world are simple. Where aid for the poorest is concerned, is evidence collected and analysed with enough rigour to enable well-informed decisions to be made? 相似文献
80.
Chris Lange 《Nonprofit management & leadership》2003,13(3):237-252
The process of European integration affects an increasing number of areas of life. The influence of the European single market on the social sector, including organizations providing human services, can no longer be denied. This article looks at the activities of the European Commission toward these organizations and argues that European regulations are relevant to the German system of social service delivery due to the introduction of market‐like features in the national context. Within this context, German welfare organizations have discovered an important field of interest representation and lobbying. 相似文献