Oxidative stress increases continuously with BMI and age with unfavourable profiles in males

Oxidative stress is a risk factor for chronic diseases and was previously shown to be independently associated with obesity. The authors investigated the relationship between body mass index (BMI), age and oxidative stress on 2190 subjects undergoing a health care examination. Total antioxidant status (TAS), total peroxides (TOC) and autoantibodies against oxidized LDL (oLAb) were used as oxidative stress biomarkers in addition to serum lipoproteins, bilirubin and uric acid. Gender-specific differences were observed for age, BMI, serum concentrations of bilirubin, low-density lipoprotein (LDL), uric acid and TAS, all of which were higher in males (p < 0.001), while high-density lipoprotein (HDL), HDL/LDL ratio and TOC were higher in females (p < 0.001). Total cholesterol (p < 0.05) and LDL were increased (p < 0.05), while HDL was decreased (p < 0.05) in overweight and obese subjects. This was accompanied by increased uric acid and TAS concentrations. Lowest oLAb titers were detected in obese subjects. In extremely obese subjects, increased TOC and decreased TAS were observed in spite of high uric acid levels. These results demonstrate that oxidative stress increases with increasing BMI and age, as a sequel to an impaired antioxidant status, the consumption of oLAbs, an increase of peroxides and uric acid and a disadvantaged lipid profile.     

Attachment to Mothers and Fathers during Middle Childhood: Associations with Child Gender, Grade, and Competence

Attachment relationships of first, third, and fifth graders with their mothers and fathers, and their associations with self‐perceived and teacher‐rated competence, were investigated. Children rated their attachment security with mothers and fathers using the Kerns security scale. Children's perceptions of academic and peer competence were measured using Harter's self‐perception profile, and teachers also rated children's competence. Girls felt greater attachment security to their mothers than to their fathers, and boys felt greater attachment security to their fathers than did girls. Greater attachment security with both mothers and fathers was associated with children's perceptions of greater peer and academic competence, and this association was stronger for older children. A greater sense of attachment security with both parents was associated with greater competence than a sense of attachment security with only one parent. Teacher‐rated competence was significantly related to attachment security with mothers but not fathers.     

On Multicollinearity and Concurvity in Some Nonlinear Multivariate Models

Recent developments of multivariate smoothing methods provide a rich collection of feasible models for nonparametric multivariate data analysis. Among the most interpretable are those with smoothed additive terms. Construction of various methods and algorithms for computing the models have been the main concern in literature in this area. Less results are available on the validation of computed fit, instead, and many applications of nonparametric methods end up in computing and comparing the generalized validation error or related indexes. This article reviews the behaviour of some of the best known multivariate nonparametric methods, based on subset selection and on projection, when (exact) collinearity or multicollinearity (near collinearity) is present in the input matrix. It shows the possible aliasing effects in computed fits of some selection methods and explores the properties of the projection spaces reached by projection methods in order to help data analysts to select the best model in case of ill conditioned input matrices. Two simulation studies and a real data set application are presented to illustrate further the effects of collinearity or multicollinearity in the fit.     

Silent dark: the orders of silence

ABSTRACT

This article examines anxiety, arguing that it is a systemic feature of neoliberalism which regenerates the economy and acts in a conservative manner, thereby effectively preventing social change. Anxiety is explored using psychoanalytic theory to extend Foucault’s conception of neoliberal governmentality as proposed in his lectures on neoliberalism at the Collège de France. Relying on Foucault’s notion of governmentality as an analytic perspective, this article does not present the economy or the state as the origin of power in neoliberalism. Rather, these are seen as mediums of power, whereas the anchorage point of power relations is understood to be a particular form of governmentality. In neoliberalism, this anchorage point of power is largely supported and strongly characterised by anxiety. While examining the psychic life of power in neoliberalism, I avoid positioning and thus analysing anxiety either on the individual or the macro level of society. Rather, showing that anxiety exposes the weakness of such clean divisions, it is argued that neoliberal subjects are nowadays governed through anxiety.     

Bayes factors for goodness of fit testing

We propose the use of the generalized fractional Bayes factor for testing fit in multinomial models. This is a non-asymptotic method that can be used to quantify the evidence for or against a sub-model. We give expressions for the generalized fractional Bayes factor and we study its properties. In particular, we show that the generalized fractional Bayes factor has better properties than the fractional Bayes factor.     

Antidepressants for neuroenhancement in healthy individuals: a systematic review

Neuroenhancement offers the prospect of improving the cognitive, emotional and motivational functions of healthy individuals. Of all the conceivable interventions, psychopharmacology provides the most readily available ones, such as antidepressants which are thought to make people “better than well”. However, up until now, whether they possess such an enhancing ability remains controversial and therefore in this systematic review we will evaluate the effect and safety of modern antidepressants in healthy individuals. A search of MEDLINE and EMBASE databases and cross-references was carried out and the pharmaceutical industry was contacted for suitable data. Trials published in any language through the third week of July 2007 were regarded. Included were single or double blind randomised or quasi-randomised controlled trials that compared a placebo to one or more of the following antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, moclobemide, paroxetine, reboxetine, sertraline or venlafaxine in any dose or dosing schedule. Eligible studies were those involving healthy people of any age and either sex who showed no evidence of a psychiatric disorder, cognitive decline or other disease. One hundred thirty-five articles met our inclusion criteria reporting single dose trials and trials with repeated drug administration. Sixty-five of these articles were eligible for a statistical analysis. Based on a linear mixed model, a meta-analysis and a fixed effects meta-regression were performed. Pooling of results by meta-analysis was stratified by the outcome measures (a) mood, (b) emotional processing, (c) wakefulness, (d) attention, (e) memory, and (f) executive functions. On a significance level of p < 0.05 the following significant results emerged: After a single dose of an antidepressant, a significant effect was shown in two of the analysed outcomes. Firstly, there was a small yet significant negative effect on wakefulness. On memory, a positive effect after several measurements was found, but this result could be traced to the results of the one study out of all included studies, which had that many assessment points. The analysis of trials with repeated drug administration (mean duration 14 days, standard deviation 9) yielded the following effects: on mood, a non-significant positive effect was detected that was continuously increasing and reached significance at the last assessment point. Regarding attention, a fluctuating effect was found, while for memory, the fact that the two groups started with a group difference confounded the results. For wakefulness there was no significant effect in any particular assessment point, while for emotional processing and executive functions, the small number of studies did not allow for any effect to emerge. In summary, no consistent evidence for enhancing effects of antidepressants could be found. There is little evidence so far to support the popular opinion that antidepressants have a positive effect on the mood of healthy individuals after repeated administration. No evidence of a significant adverse event profile could be found. The studies included in this systematic review not only provide insufficient evidence for or against any effect in healthy people, but they are inapt to be used for answering this question. This may be explained by the fact that most of them were not designed to examine neuroenhancement effects. The growing public interest in neuroenhancement stands in stark contrast to the paucity of data on enhancement effects of available psychopharmacological agents.     

Gesundheitsförderliche Arbeitsgestaltung als Ansatzpunkt für das Recruiting in der Zeitarbeit

Temporary work agencies are constantly seeking new personnel. However, the industry’s image as well as reports on unfavourable working conditions impede the recruitment of new temporary agency workers (TAW). In the present study semi-structured interviews were conducted with 11 TAW to identify work characteristics that are perceived as potentially stressful and motivating, respectively. The results of the interview study can yield valuable hints for the improvement of the quality of work and further support the recruitment of new TAW. The results show that the working conditions of TAW contain a multitude of demands – e.g., high levels of insecurity, flexibility requirements and experiences of social marginalization – but only few resources. Starting from these insights possible measures are discussed that are suitable to improve TAW’s working conditions and provide recruiters with valuable arguments for the recruitment of new staff.