The Job Demands-Job Control Model and absence behaviour: results of a 3-year longitudinal study

Empirical results of earlier studies only marginally supported the relevance of Karasek's Job Demands-Job Control Model for absence behaviour. Since longitudinal studies with respect to these relations were largely lacking, a four-wave panel study was carried out using data from 1755 male employees of a technical maintenance firm in the public sector. Job demands, job control, physical working conditions, and the employee's age, education, and health were measured in one year and absenteeism in the same year and in the next 3 years. Data were analysed with linear regression and Poisson regression techniques. The Poisson regression technique was superior to the linear regression technique in explaining absence. Age, health and prior absence were the best predictors of later absence behaviour. With respect to the Job Demands-Job Control Model, the main findings of the study were (1) that job control was significantly associated with a low number of simultaneous and later absence days, and (2) that, contrary to expectations, job demands were also related to a low number of simultaneous and later absence days. These results hold when age, health, education, prior absence, and working conditions are controlled for. Job control and job demands did not predict later absence frequency. In the discussion it is suggested that a high level of job demands may not only be harmful for the well-being of employees but also work as 'a pressure to attend'.     

Marketing and the medical specialist in the managed care environment

Marketing means more than just communicating or advertising to potential patients; marketing means identifying your customers and working to meet or exceed their expectations. There are five key areas of a marketing plan: (1) Establish the foundation, beginning with your mission statement; (2) Assess your marketing environment by internal and external research; (3) Target your efforts, looking at image and perception; (4) Develop your particular mix of product, price, place of distribution, and promotion; and (5) implement and evaluate your marketing process. This article discusses the importance of a marketing plan for the medical specialist and highlights the features unique to a practice working in a system of capitated reimbursement. Applying these principles will help to demonstrate added value, protect the fundamental role of the patient-physician relationship, ensure that our efforts are aligned with professional missions and goals, and ultimately increase profitability and professional success.     

基于SYS-GMM的中国人口结构变化与经济增长关系研究

本文利用中国29个省份20年的面板数据,探讨了人口结构变化对储蓄、投资和经济增长的影响。我们将人口结构指标引入传统的经济增长模型中,并用固定效应模型和SYS-GMM计量方法分别测算其对储蓄、投资和经济增长的效应。考虑到老年抚养比在经济增长方程的内生性,我们还将滞后30年的就业人数比率作为工具变量来识别老年抚养比对经济增长的因果效应。结果显示老年抚养率对储蓄、投资和经济增长存在显著的正相关。人口增长率对储蓄和投资有着负相关,但对经济增长没有影响。工作年龄人口比率对储蓄率存在负相关,对投资和经济增长存在正向影响但估计的回归系数不显著。在加入其它制度和人口变量之后回归结果依然稳定。     

The negative binomial–beta Weibull regression model to predict the cure of prostate cancer

In this article, for the first time, we propose the negative binomial–beta Weibull (BW) regression model for studying the recurrence of prostate cancer and to predict the cure fraction for patients with clinically localized prostate cancer treated by open radical prostatectomy. The cure model considers that a fraction of the survivors are cured of the disease. The survival function for the population of patients can be modeled by a cure parametric model using the BW distribution. We derive an explicit expansion for the moments of the recurrence time distribution for the uncured individuals. The proposed distribution can be used to model survival data when the hazard rate function is increasing, decreasing, unimodal and bathtub shaped. Another advantage is that the proposed model includes as special sub-models some of the well-known cure rate models discussed in the literature. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We analyze a real data set for localized prostate cancer patients after open radical prostatectomy.     

Bayesian semiparametric modeling and inference with mixtures of?symmetric distributions

We propose a semiparametric modeling approach for mixtures of symmetric distributions. The mixture model is built from a common symmetric density with different components arising through different location parameters. This structure ensures identifiability for mixture components, which is a key feature of the model as it allows applications to settings where primary interest is inference for the subpopulations comprising the mixture. We focus on the two-component mixture setting and develop a Bayesian model using parametric priors for the location parameters and for the mixture proportion, and a nonparametric prior probability model, based on Dirichlet process mixtures, for the random symmetric density. We present an approach to inference using Markov chain Monte Carlo posterior simulation. The performance of the model is studied with a simulation experiment and through analysis of a rainfall precipitation data set as well as with data on eruptions of the Old Faithful geyser.     

Two-stage hierarchical modeling for analysis of subpopulations in conditional distributions

In this work, we develop modeling and estimation approach for the analysis of cross-sectional clustered data with multimodal conditional distributions where the main interest is in analysis of subpopulations. It is proposed to model such data in a hierarchical model with conditional distributions viewed as finite mixtures of normal components. With a large number of observations in the lowest level clusters, a two-stage estimation approach is used. In the first stage, the normal mixture parameters in each lowest level cluster are estimated using robust methods. Robust alternatives to the maximum likelihood estimation are used to provide stable results even for data with conditional distributions such that their components may not quite meet normality assumptions. Then the lowest level cluster-specific means and standard deviations are modeled in a mixed effects model in the second stage. A small simulation study was conducted to compare performance of finite normal mixture population parameter estimates based on robust and maximum likelihood estimation in stage 1. The proposed modeling approach is illustrated through the analysis of mice tendon fibril diameters data. Analyses results address genotype differences between corresponding components in the mixtures and demonstrate advantages of robust estimation in stage 1.     

Comparisons of Test Statistics Arising from Marginal Analyses of Multivariate Survival Data

We investigate the properties of several statistical tests for comparing treatment groups with respect to multivariate survival data, based on the marginal analysis approach introduced by Wei, Lin and Weissfeld [Regression Analysis of multivariate incomplete failure time data by modelling marginal distributians, JASA vol. 84 pp. 1065–1073]. We consider two types of directional tests, based on a constrained maximization and on linear combinations of the unconstrained maximizer of the working likelihood function, and the omnibus test arising from the same working likelihood. The directional tests are members of a larger class of tests, from which an asymptotically optimal test can be found. We compare the asymptotic powers of the tests under general contiguous alternatives for a variety of settings, and also consider the choice of the number of survival times to include in the multivariate outcome. We illustrate the results with simulations and with the results from a clinical trial examining recurring opportunistic infections in persons with HIV.     

Interval estimation for log-linear models with one variable subject to non-ignorable non-response

Summary.  Log-linear models for multiway contingency tables where one variable is subject to non-ignorable non-response will often yield boundary solutions, with the probability of non-respondents being classified in some cells of the table estimated as 0. The paper considers the effect of this non-standard behaviour on two methods of interval estimation based on the distribution of the maximum likelihood estimator. The first method relies on the estimator being approximately normally distributed with variance equal to the inverse of the information matrix. It is shown that the information matrix is singular for boundary solutions, but intervals can be calculated after a simple transformation. For the second method, based on the bootstrap, asymptotic results suggest that the coverage properties may be poor for boundary solutions. Both methods are compared with profile likelihood intervals in a simulation study based on data from the British General Election Panel Study. The results of this study indicate that all three methods perform poorly for a parameter of the non-response model, whereas they all perform well for a parameter of the margin model, irrespective of whether or not there is a boundary solution.     

Detection of structural breaks in a time-varying heteroskedastic regression model

A Bayesian method for estimating a time-varying regression model subject to the presence of structural breaks is proposed. Heteroskedastic dynamics, via both GARCH and stochastic volatility specifications, and an autoregressive factor, subject to breaks, are added to generalize the standard return prediction model, in order to efficiently estimate and examine the relationship and how it changes over time. A Bayesian computational method is employed to identify the locations of structural breaks, and for estimation and inference, simultaneously accounting for heteroskedasticity and autocorrelation. The proposed methods are illustrated using simulated data. Then, an empirical study of the Taiwan and Hong Kong stock markets, using oil and gas price returns as a state variable, provides strong support for oil prices being an important explanatory variable for stock returns.     

Statistical approaches for conducting network meta-analysis in drug development

We introduce health technology assessment and evidence synthesis briefly, and then concentrate on the statistical approaches used for conducting network meta-analysis (NMA) in the development and approval of new health technologies. NMA is an extension of standard meta-analysis where indirect as well as direct information is combined and can be seen as similar to the analysis of incomplete-block designs. We illustrate it with an example involving three treatments, using fixed-effects and random-effects models, and using frequentist and Bayesian approaches. As most statisticians in the pharmaceutical industry are familiar with SAS? software for analyzing clinical trials, we provide example code for each of the methods we illustrate. One issue that has been overlooked in the literature is the choice of constraints applied to random effects, and we show how this affects the estimates and standard errors and propose a symmetric set of constraints that is equivalent to most current practice. Finally, we discuss the role of statisticians in planning and carrying out NMAs and the strategy for dealing with important issues such as heterogeneity.