A classification updating procedure motivated by high-content screening data

The current paradigm for the identification of candidate drugs within the pharmaceutical industry typically involves the use of high-throughput screens. High-content screening (HCS) is the term given to the process of using an imaging platform to screen large numbers of compounds for some desirable biological activity. Classification methods have important applications in HCS experiments, where they are used to predict which compounds have the potential to be developed into new drugs. In this paper, a new classification method is proposed for batches of compounds where the rule is updated sequentially using information from the classification of previous batches. This methodology accounts for the possibility that the training data are not a representative sample of the test data and that the underlying group distributions may change as new compounds are analysed. This technique is illustrated on an example data set using linear discriminant analysis, k-nearest neighbour and random forest classifiers. Random forests are shown to be superior to the other classifiers and are further improved by the additional updating algorithm in terms of an increase in the number of true positives as well as a decrease in the number of false positives.     

Desegregation in Higher Education: An Examination of Traditionally Black and White Institutions*

Using the data collection techniques of historical analysis, secondary analysis of EEO-6 records, mailed questionnaires, and personal interviews, race relations among trustees, administrators, and faculty in the southeastern United States were examined during the late 1970s and early 1980s. The conclusion that blacks at traditionally white institutions (TWI) (1) had more tenuous job status, (2) experienced less job satisfaction, (3) experienced greater degrees of institutional alienation, and (4) more often stated a need for affirmative action programs than did their white colleagues at the same institution will surprise no one. Similar patterns and perceptions were found for whites at traditionally black institutions (TBI) where whites were in the “minority.” Although whites at TBIs remained members of the societal majority group as traditionally defined in the sociology of intergroup relations, their position and perceptions within specific TBIs were remarkably similar to the experience of black professionals at TWIs. Some implications for policy are drawn.     

FIRM HETEROGENEITY AND THE PATTERN OF R&D COLLABORATIONS

We consider an oligopoly setting in which firms form pairwise collaborative links in research and development with other firms. Each collaboration generates a value that depends on the identity of the firms that collaborate. First, we provide properties satisfied by pairwise equilibrium networks and efficient networks. Second, we use these properties in two types of situation: (1) there are two groups of firms, and the value of a collaboration is higher when firms belong to the same group; (2) some firms have more innovative capabilities than others. These two situations provide clear insights about how firms' heterogeneity affects both equilibrium and efficient networks. We also show that the most valuable collaborative links do not always appear in equilibrium, and a public policy that increases the value of the most valuable links may lead to a loss of social welfare. (JEL C70, L13, L20)     

RENT CREATION AND RENT SHARING: NEW MEASURES AND IMPACTS ON TOTAL FACTOR PRODUCTIVITY

This analysis proposes new measures of rent creation and rent sharing and assesses their impact on productivity on cross‐country‐industry panel data. We find first that: (1) anticompetitive product market regulations positively affect rent creation and (2) employment protection legislation boosts hourly wages, particularly for low‐skill workers. However, we find no significant impact of this employment legislation on rent sharing, as the hourly wage increases are offset by a negative impact on hours worked. Second, using regulation indicators as instruments, we find that rent creation and rent sharing both have a substantial negative impact on total factor productivity. (JEL E22, E24, O30, L50, O43, O47, C23)     

Fundamentals for an International Typology of Social Enterprise Models

The quest for a widely accepted definition of social enterprise (SE) has been a central issue in the last two decades. However, it only seems feasible today to identify a few criteria that were most debated: the specific role of individual social entrepreneurs, the place of social innovation, the search for market income and the issue of governance. The arena of conceptualization efforts should now be fed with more contributions starting from bottom-up approaches built upon a hypothesis that could be termed “the impossibility of a unified definition”. In this paper, we develop a theoretical framework combining principles of interest (mutual, general and capital interest) and resource mixes to identify institutional trajectories generating four major SE models. We then show that all four SE models may address the actual diversity of SE’s social missions. Finally, we suggest that such social missions may be enhanced differently depending on the respective governance mechanisms.     

Nest design in a changing world: Great tit <Emphasis Type="Italic">Parus major</Emphasis> nests from a Mediterranean city environment as a case study

Investigations of urbanization effects on birds have focused mainly on breeding traits expressed after the nest-building stage (e.g. first-egg date, clutch size, breeding success, and offspring characteristics). Urban studies largely ignored how and why the aspects of nest building might be associated with the degree of urbanization. As urban environments are expected to present novel environmental changes relative to rural environments, it is important to evaluate how nest-building behavior is impacted by vegetation modifications associated with urbanization. To examine nest design in a Mediterranean city environment, we allowed urban great tits (Parus major) to breed in nest boxes in areas that differed in local vegetation cover. We found that different measures of nest size or mass were not associated with vegetation cover. In particular, nests located adjacent to streets with lower vegetation cover were not smaller or lighter than nests in parks with higher vegetation cover. Nests adjacent to streets contained more pine needles than nests in parks. In addition, in nests adjacent to streets, nests from boxes attached to pine trees contained more pine needles than nests from boxes attached to other trees. We suggest that urban-related alterations in vegetation cover do not directly impose physical limits on nest size in species that are opportunistic in the selection of nesting material. However, nest composition as reflected in the use of pine needles was clearly affected by habitat type and the planted tree species present, which implies that rapid habitat change impacts nest composition. We do not exclude that urbanization might impact other aspects of nest building behaviour not covered in our study (e.g. costs of searching for nest material), and that the strengths of the associations between urbanization and nest structures might differ among study populations or species.     

Importance of fairness in humanitarian relief distribution

Abstract

This article is inspired by some of the challenges faced by non-governmental organizations in the distribution of humanitarian relief to vulnerable rural communities. A major concern of these organizations is to warrant that relief is distributed in an impartial and transparent way, which gives rise to the notion of fairness. This article thus discusses the importance of fairness in relief distribution and how it can be defined, especially in a context where delivery of vital items must be ensured periodically. We also propose some performance indicators to measure fairness, which can be useful to organizations that are held accountable for the impartiality of their decisions. Finally, an empirical study of an academic case, inspired by a rural aid distribution problem, is used to analyse how different mathematical formulations may contribute in helping crisis managers integrate fairness or equity in their decisions.     

Physical education and sport teachers' health: from expressed ill-being to hindrances of action

The researches that specifically analyse the working conditions of teachers are few in the ergonomic literature. Our research relates more specifically to teachers of physical education and sports in french context of college. The research project described here includes both a quantitative exploratory survey (218 respondents) and qualitative case studies (interviews and observation), using the general framework of Activity Ergonomics. The results of this exploratory work tend to emphasize the importance of collective and organizational dimensions in the experience of teachers' physical education and sports. Specifically, in a perceived context of degradation of working conditions and accumulation of constraints, the collective and local ability to negotiate the various constraints on the activity appears to be a protective factor. This power to act, these margin of manoeuvre could be a relevant topic for future research.     

Voluntas Symposium: Comments on Salamon and Sokolowski’s Re-conceptualization of the Third Sector

With their “Beyond Nonprofits: Re-conceptualizing the Third Sector”, Salamon and Sokolowski have made an important contribution to the ongoing debate on how to define the third sector. This Voluntas symposium brings together the comments of five leading scholars both supportive and critical of the new definition. The comments are based on a debate held at the conference of the International Society for Third Sector Research, in Stockholm in 2016.