On estimands and the analysis of adverse events in the presence of varying follow‐up times within the benefit assessment of therapies

The analysis of adverse events (AEs) is a key component in the assessment of a drug's safety profile. Inappropriate analysis methods may result in misleading conclusions about a therapy's safety and consequently its benefit‐risk ratio. The statistical analysis of AEs is complicated by the fact that the follow‐up times can vary between the patients included in a clinical trial. This paper takes as its focus the analysis of AE data in the presence of varying follow‐up times within the benefit assessment of therapeutic interventions. Instead of approaching this issue directly and solely from an analysis point of view, we first discuss what should be estimated in the context of safety data, leading to the concept of estimands. Although the current discussion on estimands is mainly related to efficacy evaluation, the concept is applicable to safety endpoints as well. Within the framework of estimands, we present statistical methods for analysing AEs with the focus being on the time to the occurrence of the first AE of a specific type. We give recommendations which estimators should be used for the estimands described. Furthermore, we state practical implications of the analysis of AEs in clinical trials and give an overview of examples across different indications. We also provide a review of current practices of health technology assessment (HTA) agencies with respect to the evaluation of safety data. Finally, we describe problems with meta‐analyses of AE data and sketch possible solutions.     

Ethnic Language Retention and East Asian Endogamy in the United States

This study examines the influence of ethnic language on the endogamy of three East Asian groups, which have been previously omitted within intermarriage research. The study findings present important indications of ethnic language playing a key role in endogamy amongst East Asian groups. Providing for this key component, the groups were divided into U.S. born vs. foreign-born East Asians. Amongst foreign-born East Asians, the effect of English ability provided significance over U.S. born East Asians. Separate examinations of Chinese, Japanese, and Koreans presented diverse patterns of endogamy, migration, and ethnic language retention. Specifically, findings provided insight to high levels of endogamy amongst U.S. born Japanese due to ethnic concentration, despite their loss of ethnic language.     

WHO WINS IN AN ENERGY BOOM? EVIDENCE FROM WAGE RATES AND HOUSING

This article presents evidence on the distributional effects of energy extraction by examining the effect of the recent U.S. energy boom on wage rates and housing. The boom increased local wage rates in almost every major occupational category. The increase occurred regardless of whether the occupation experienced a corresponding change in employment, suggesting a tighter labor market that benefited local workers. Wage rates also increased substantially across the entire wage rate distribution, although the percentage increase was slightly higher at the bottom of the distribution than at the top. Local housing values and rental prices both increased, thereby benefiting landowners. For renters, the increase in prices was completely offset by a contemporaneous increase in income. The results suggest that bans on drilling have negative monetary consequences for a large share of local residents. (JEL J23, Q33, R31)     

Variability of agroecosystems and landscape service provision on the urban–rural fringe of Wuhan,Central China

Urban Ecosystems - Urbanization drives changes in peri-urban farmland use which probably affects the spatial pattern of landscape service provision. This study charts patterns in these services and...     

A comparison of state support for young people leaving care in Norway and Sweden: Differences within comparable welfare systems

The aim of this article is to account for and discuss support to young care leavers within the comparable welfare regimes of Norway and Sweden and to explore key differences between these 2 countries. This model implies that children and young people are included and entitled to support through being family members, not as independent actors in their own right. This makes young care leaver's transition from care to adulthood problematic—as they often do not have access to family support, they may be positioned in a vacuum where they are clients neither entitled to support from the child welfare system nor supported by their families of origin. In Norway, legislators and policymakers have agreed that care leavers need particular attention and targeted support, whereas in Sweden, there has been no such agreement. However, the Norwegian system of giving leaving care services is not strong enough to provide transition support to all care leavers, even if the legislation gives stronger protection than in Sweden. The article discusses the need for targeted measures of support for a successful care‐leaving process.     

Care Farms in the Netherlands: An Underexplored Example of Multifunctional Agriculture—Toward an Empirically Grounded,Organization‐Theory‐Based Typology

For agricultural and rural development in Europe, multifunctionality is a leading concept that raises many questions. Care farming is a promising example of multifunctional agriculture that has so far received little attention. An issue that has not been examined thoroughly is the strategic mapping of different care farm organizations in this emerging field. The objective of this article is to develop a typology for care farms in the Netherlands and provide insight into the diversity of care farms. We have used different concepts from organization theory and information from regional organizations of care farmers to identify key dimensions and develop a typology of care farms. Key dimensions are the ratio between agriculture and care, the background of the initiators, and the degree of collaboration with formal care institutions. We found six main types of care farms with different identities, four of which were initiated by the farmers' families (mainly female partners). The other two types were started by new entrants in agriculture. On the basis of our findings, we confirmed, disputed, and supplemented insights to multifunctional farming literature. As a further contribution to that field, drawing from the organization theories underlying our typology, we have sought to understand how different types of care farms could emerge.     

A generalized representation theorem for Harsanyi’s (‘impartial’) observer

We provide an axiomatization of an additively separable social welfare function in the context of Harsanyi’s impartial observer theorem. To do this, we reformulate Harsanyi’s setting to make the lotteries over the identities the observer may assume independent of the social alternative.     

‘The silence is roaring’: sterilization,reproductive rights and women with intellectual disabilities

This paper reviews the history of sterilization of women with intellectual disabilities, and considers its relevance to current practice regarding reproductive choice and futures. The paper provides an overview of published research on historical practices, focusing on the United Kingdom, the United States, Canada and the Nordic countries. Most of this research draws upon written records, centring on eugenics debates. However, emerging oral history testimonies gathered by the authors suggest that sterilization procedures were also conducted in the community, the result of private negotiations between parents and medical practitioners. The article presents these accounts and calls for an end to a ‘roaring silence’ on this issue. More empirical studies are needed to recover the experiences of women who have been sterilized and to explore how decisions about reproductive choice and capacity were made in the past and continue to be made today.     

Gender Gaps in Educational Attainment in Less Developed Countries

Conventional wisdom holds that gender gaps in schooling favoring males in developing countries generally are large, though probably declining. In this article we re‐examine recent gender gaps in schooling in the developing world and come to a more nuanced characterization of their nature, which suggests that the developing countries are becoming more like the developed countries, with gender gaps that increasingly favor, rather than discriminate against, females. Using data from 38 countries with multiple Demographic and Health Surveys, we examine how the gender gaps in current school enrollment and grade completion emerge across the educational life course from age 6 to 18. We also examine how these age‐specific measures have changed over time, comparing the periods 1990–99 and 2000–06. Our analyses indicate that among children who have ever attended school, girls younger than 16 years of age have equal or greater schooling progress than boys of the same age in all regions of the developing world.     

Partners’ Educational Pairings and Fertility Across Europe

We provide new evidence on the education-fertility relationship by using EU-SILC panel data on 24 European countries to investigate how couples’ educational pairings predict their childbearing behavior. We focus on differences in first-, second-, and third-birth rates among couples with varying combinations of partners’ education. Our results show important differences in how education relates to parity progressions depending on the education of the partner. First, highly educated homogamous couples show a distinct childbearing behavior in most country clusters. They tend to postpone the first birth most and display the highest second- and third-birth rates. Second, contrary to what may be expected based on the “new home economics” approach, hypergamous couples with a highly educated male and a lower-educated female partner display among the lowest second-birth transitions. Our findings underscore the relevance of interacting both partners’ education for a better understanding of the education-fertility relationship.