A time-varying measurement error model for age of onset of a psychiatric diagnosis: applied to first depressive episode diagnosed by the Composite International Diagnostic Interview (CIDI)

A substantial degree of uncertainty exists surrounding the reconstruction of events based on memory recall. This form of measurement error affects the performance of structured interviews such as the Composite International Diagnostic Interview (CIDI), an important tool to assess mental health in the community. Measurement error probably explains the discrepancy in estimates between longitudinal studies with repeated assessments (the gold-standard), yielding approximately constant rates of depression, versus cross-sectional studies which often find increasing rates closer in time to the interview. Repeated assessments of current status (or recent history) are more reliable than reconstruction of a person's psychiatric history based on a single interview. In this paper, we demonstrate a method of estimating a time-varying measurement error distribution in the age of onset of an initial depressive episode, as diagnosed by the CIDI, based on an assumption regarding age-specific incidence rates. High-dimensional non-parametric estimation is achieved by the EM-algorithm with smoothing. The method is applied to data from a Norwegian mental health survey in 2000. The measurement error distribution changes dramatically from 1980 to 2000, with increasing variance and greater bias further away in time from the interview. Some influence of the measurement error on already published results is found.     

Projection Measures And Estimation Variances Of Intensities

The paper investigates random processes of geometrical objects in Euclidean spaces. General properties of the measure of total projections are derived by means of Palm distribution. Explicit formulas for variances of the projection measure are obtained for Poisson point processes of compact sets.

Intensity estimators of fibre (surface) processes are then studied by means of projection measures. Classification of direct and indirect probes is introduced. The indirect sampling design of vertical sections and projections is generalized and its statistical properties derived.     

Statistical Certification of Software Systems

Common software release procedures based on statistical techniques try to optimize the trade-off between further testing costs and costs due to remaining errors. We propose new software release procedures where the aim is to certify with a certain confidence level that the software does not contain errors. The underlying model is a discrete time model similar to the geometric Moranda model. The decisions are based on a mix of classical and Bayesian approaches to sequential testing and do not require any assumption on the initial number of errors.     

A specification strategy for order determination in arma models

In this paper a specification strategy is proposed for the determination of the orders in ARMA models. The strategy is based on two newly defined concepts: the q-conditioned partial auto-regressive function and the p-conditioned partial moving average function. These concepts are similar to the generalized partial autocorrelation function which has been recently suggested for order determination. The main difference is that they are defined and employed in connection with an asymptotically efficient estimation method instead of the rather inefficient generalized Yule-Walker method. The specification is performed by using sequential Wald type tests. In contrast to the traditional testing of hypotheses, these tests use critical values which increase with the sample size at an appropriate rate     

Selection of bandwidth for kernel regression

ABSTRACT

The most important factor in kernel regression is a choice of a bandwidth. Considerable attention has been paid to extension the idea of an iterative method known for a kernel density estimate to kernel regression. Data-driven selectors of the bandwidth for kernel regression are considered. The proposed method is based on an optimally balanced relation between the integrated variance and the integrated square bias. This approach leads to an iterative quadratically convergent process. The analysis of statistical properties shows the rationale of the proposed method. In order to see statistical properties of this method the consistency is determined. The utility of the method is illustrated through a simulation study and real data applications.     

Non parametric portmanteau tests for detecting non linearities in high dimensions

ABSTRACT

We propose two non parametric portmanteau test statistics for serial dependence in high dimensions using the correlation integral. One test depends on a cutoff threshold value, while the other test is freed of this dependence. Although these tests may each be viewed as variants of the classical Brock, Dechert, and Scheinkman (BDS) test statistic, they avoid some of the major weaknesses of this test. We establish consistency and asymptotic normality of both portmanteau tests. Using Monte Carlo simulations, we investigate the small sample properties of the tests for a variety of data generating processes with normally and uniformly distributed innovations. We show that asymptotic theory provides accurate inference in finite samples and for relatively high dimensions. This is followed by a power comparison with the BDS test, and with several rank-based extensions of the BDS tests that have recently been proposed in the literature. Two real data examples are provided to illustrate the use of the test procedure.     

The Modeling and Seasonal Adjustment of Weekly Observations

Several important economic time series are recorded on a particular day every week. Seasonal adjustment of such series is difficult because the number of weeks varies between 52 and 53 and the position of the recording day changes from year to year. In addition certain festivals, most notably Easter, take place at different times according to the year. This article presents a solution to problems of this kind by setting up a structural time series model that allows the seasonal pattern to evolve over time and enables trend extraction and seasonal adjustment to be carried out by means of state-space filtering and smoothing algorithms. The method is illustrated with a Bank of England series on the money supply.     

Mean intergrated squared error properties and optimal kernels when estimating a diatribution function

Let X₁,X₂,… X_n be a sample of independent identically distributed (i.i.d)random variables having an unknown absolutely continuous distribution function f with density f the twofold aim of his paper consists in, firstly deriving asymptotic expressions of the mean intergrated squared error (MISE) of a kernel estimator of F when f is either assumed to be continuous everywhere or problem of finding optimal kernels in these two cases is studied in detail.     

State transition modeling of complex monitored health data

This article considers the analysis of complex monitored health data, where often one or several signals are reflecting the current health status that can be represented by a finite number of states, in addition to a set of covariates. In particular, we consider a novel application of a non-parametric state intensity regression method in order to study time-dependent effects of covariates on the state transition intensities. The method can handle baseline, time varying as well as dynamic covariates. Because of the non-parametric nature, the method can handle different data types and challenges under minimal assumptions. If the signal that is reflecting the current health status is of continuous nature, we propose the application of a weighted median and a hysteresis filter as data pre-processing steps in order to facilitate robust analysis. In intensity regression, covariates can be aggregated by a suitable functional form over a time history window. We propose to study the estimated cumulative regression parameters for different choices of the time history window in order to investigate short- and long-term effects of the given covariates. The proposed framework is discussed and applied to resuscitation data of newborns collected in Tanzania.