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Effective recruitment is a prerequisite for successful execution of a clinical trial. ALLHAT, a large hypertension treatment trial (N = 42,418), provided an opportunity to evaluate adaptive modeling of recruitment processes using conditional moving linear regression. Our statistical modeling of recruitment, comparing Brownian and fractional Brownian motion, indicates that fractional Brownian motion combined with moving linear regression is better than classic Brownian motion in terms of higher conditional probability of achieving a global recruitment goal in 4-week ahead projections. Further research is needed to evaluate how recruitment modeling can assist clinical trialists in planning and executing clinical trials.  相似文献   
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ABSTRACT

This study sheds new light on the role of identity in virtual environments when virtual representation of self is in support of disabled individuals and the potential impact of their virtual identity on work opportunities. It is widely understood that individuals who live with disability often experience a lifetime of bullying, exclusion, marginalization and rejection. They often experience workplace bias and discrimination. Yet, when they can create an identity and experience embodiment in virtual environments, the results can be extraordinarily powerful – even life-changing. This research builds on nearly a decade of ethnographic research in 3D online immersive social virtual worlds; seven of those years working with disability communities to answer the following: RQ1: In a virtual world where one can choose any avatar form, how does that visual sense of self-representation influence one’s ability to gain access to a social network, to be a leader in that network, and to find work? RQ2: How does realism in representation influence work experiences in these digital worlds? The results reveal the importance of choice in online representation of avatars in creating work and online social engagement. Implications contribute to our understanding of visual bias in the workplace and how emerging virtual reality technologies may open new avenues for meaningful work and social interactions for people with disabilities.  相似文献   
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Research on the functional independence of verbal operants (Skinner, 1957) has demonstrated inconsistent findings. One explanation may be that these studies have not manipulated the motivating operation (MO) to facilitate the emergence of mands (Hall & Sundberg, 1987; Lamarre & Holland, 1985). In the current study, 1 participant, diagnosed with autism, was taught to tact high-preference and low-preference leisure items, and emergence of mands was tested under varying MO conditions. Results showed the emergence of mands following periods of arranged deprivation, and greater maintenance for a highly preferred relative to a less preferred stimulus. However, mands only emerged when presession tact trials were conducted. These results suggest that in a state of deprivation, transfer of stimulus control from discriminative to motivational conditions may occur without direct training.  相似文献   
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Prior research on Mexican migration has shown that social networks and economic incentives play an important role in determining migration outcomes. We use experimental data from PROGRESA, Mexico's primary poverty-reduction program, to evaluate the effects of conditional cash transfers on migration both domestically and to the United States. Our study complements a growing body of literature aimed at overcoming longstanding hurdles to the establishment of causal validity in empirical studies of migration. Analysis based on the data collected before and after the program's onset shows that conditional transfers reduce U.S. migration but not domestic migration. The data also enable us to explore the role of existing family and community migration networks. The results show that migration networks strongly influence migration, but that the effect of conditional transfers on migration is apparently not mediated by existing migration network structures. Our results suggest that conditional transfers may be helpful in managing rural out-migration, particularly to the United States.  相似文献   
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Race and Social Problems - The goal of the current study was to examine the role of racial attitudes, empathic concern, and prosocial behaviors among emerging adults. Research linking racial...  相似文献   
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