计算机辅助机械设计中的成本分析

本文提出了通过机械设备生存期评估其成本的概念，描述了在机械设计过程中用计算机进行经济辅助分析，用参数化的方法进行面向机械设计的成本评估，同时讨论了基于零件特征的成本分析。     

Conditional estimation of average on the basis of weighting data

LetF(x,y) be a distribution function of a two dimensional random variable (X,Y). We assume that a distribution functionF _x(x) of the random variableX is known. The variableX will be called an auxiliary variable. Our purpose is estimation of the expected valuem=E(Y) on the basis of two-dimensional simple sample denoted by:U=[(X ₁, Y₁)…(X_n, Y_n)]=[X Y]. LetX=[X ₁…X _n]andY=[Y ₁…Y _n].This sample is drawn from a distribution determined by the functionF(x,y). LetX _(k)be the k-th (k=1, …,n) order statistic determined on the basis of the sampleX. The sampleU is truncated by means of this order statistic into two sub-samples: % MathType!End!2!1! and % MathType!End!2!1!.Let % MathType!End!2!1! and % MathType!End!2!1! be the sample means from the sub-samplesU _k,1 andU _k,2, respectively. The linear combination % MathType!End!2!1! of these means is the conditional estimator of the expected valuem. The coefficients of this linear combination depend on the distribution function of auxiliary variable in the pointx _(k).We can show that this statistic is conditionally as well as unconditionally unbiased estimator of the averagem. The variance of this estimator is derived. The variance of the statistic % MathType!End!2!1! is compared with the variance of the order sample mean. The generalization of the conditional estimation of the mean is considered, too.     

On conditional sampling strategies

Estimation of the population average by means of a conditional strategy has been considered e.g. in [2–6,9] and [10]. Let us assume that the sampling design depends on a function of an auxiliary variable called an auxiliary statistic like: the sample mean or the sample variance. Under the conditional versions of these designs several estimators of the population mean are considered: the Horvitz-Thompson statistic, ratio and regression type estimators. The unbiasedness and accuracy of the strategies are considered. The empirical example of the accuracy comparisons of strategies is developed. The conditional strategies could improve the accuracy of estimation and protect it against outliers observations.     

Lactational Transfer of Tetrachloroethylene in Rats

Tetrachloroethylene (PCE) is a commonly used organic solvent and a suspected human carcinogen, reportedly transferred to human breast milk following inhalation exposure. Transfer of PCE to milk may represent a threat to the nursing infant. A physiologically based pharmacokinetic (PBPK) model was developed to quantitatively assess the transfer of inhaled PCE into breast milk and the consequent exposure of the nursing infant. The model was validated in lactating rats. Lactating Sprague-Dawley female rats were exposed via inhalation to PCE at concentrations ranging from 20-1000 ppm, and then returned to their nursing, 10- to 11-day-old pups. Tetrachloroethylene concentrations in the air, blood, milk, and tissue were determined by gas chromatography and compared to model predictions. The model described the distribution of inhaled PCE in maternal blood and milk, as well as the nursed pup's gastrointestinal tract, blood, and tissue. Several computer simulations of PCE distribution kinetics in exhaled air, blood, and milk of exposed human subjects were run and compared with limited human data available from the literature. It is concluded that the PBPK model successfully described the concentration of PCE in both lactating rats and humans. Although predictions vs. observations were good, the model slightly underpredicted the peak whole pup PCE concentration and underpredicted systemic clearance of PCE from the pup.     

Negative situation appraisal and mental well-being among refugees in Germany: Serial mediation by religious coping and sense of coherence

It has been widely demonstrated that pre- and post-migration experiences can be highly traumatic for refugees. The purpose of this study was to assess the mediating effects of religious coping and sense of coherence on the association of negative dysfunctional situation appraisal and mental well-being among refugees. Paper surveys were completed by 600 people representing various refugee groups (mostly from Mashreq Countries) in German Bavaria, aged 18–65. Mediation analysis revealed that negative religious coping and sense of coherence singly and serially mediated the relationship between negative dysfunctional situation appraisal and well-being, whereas positive religious coping did not have statistically significant relationships with these variables. The data obtained suggest that the negative religious coping style and sense of coherence are two important targets for future experimental studies, and interventions on them may bring the synergistic effect on improving mental well-being in refugees.