Ticking fast or ticking slow, through Shc must you go?

Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66(shc) may be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins.     

After the fall: a conflict management program to foster open society

A conflict management program developed to support the transition from a closed to open society in postcommunist eastern and central Europe focuses on the future leaders of this region: adolescents.     

Processes of adjustment in organized out-of-school activities: opportunities and risks

Participation in organized out-of-school activities leads to long-term psychosocial and educational benefits for young people. Now we're learning which features of these activities best support individual children.     

Simulation for the complex Bingham distribution

The complex Bingham distribution is relevant for the shape analysis of landmark data in two dimensions. In this paper it is shown that the problem of simulating from this distribution reduces to simulation from a truncated multivariate exponential distribution. Several simulation methods are described and their efficiencies are compared.     

Nonverbal cues employed in discriminating between disabled persons and actors

Undergraduate subjects were seen to accurately discriminate between simulating actors and genuinely disabled males confined to wheelchairs. Judgments were based on skill in manipulating the wheelchair, poorer muscular development of the disabled, and on appearance of clothing. Implications for research on the disabled employing actors was discussed.This study was supported by a grant from the York University Faculty of Arts awarded to the first two authors. The project was performed as the third author's Honours thesis. The authors wish to thank all participants for their cooperation and assistance in making this research possible. The authors also wish to thank Gail Kenyon, Coordinator of the Centre for Handicapped Students who helped recruit participants for the videotaping and to Lucie Cantrell, Executive Officer of the York University Counselling and Development Centre who arranged for the use of the Centre's facilities and equipment.