Statistical inference on censored data for targeted clinical trials under enrichment design

For the traditional clinical trials, inclusion and exclusion criteria are usually based on some clinical endpoints; the genetic or genomic variability of the trial participants are not totally utilized in the criteria. After completion of the human genome project, the disease targets at the molecular level can be identified and can be utilized for the treatment of diseases. However, the accuracy of diagnostic devices for identification of such molecular targets is usually not perfect. Some of the patients enrolled in targeted clinical trials with a positive result for the molecular target might not have the specific molecular targets. As a result, the treatment effect may be underestimated in the patient population truly with the molecular target. To resolve this issue, under the exponential distribution, we develop inferential procedures for the treatment effects of the targeted drug based on the censored endpoints in the patients truly with the molecular targets. Under an enrichment design, we propose using the expectation–maximization algorithm in conjunction with the bootstrap technique to incorporate the inaccuracy of the diagnostic device for detection of the molecular targets on the inference of the treatment effects. A simulation study was conducted to empirically investigate the performance of the proposed methods. Simulation results demonstrate that under the exponential distribution, the proposed estimator is nearly unbiased with adequate precision, and the confidence interval can provide adequate coverage probability. In addition, the proposed testing procedure can adequately control the size with sufficient power. On the other hand, when the proportional hazard assumption is violated, additional simulation studies show that the type I error rate is not controlled at the nominal level and is an increasing function of the positive predictive value. A numerical example illustrates the proposed procedures. Copyright © 2013 John Wiley & Sons, Ltd.     

Pushing back the margins: power,identity and marginalia in survey research with young people

The study of marginalia has not been widely discussed in social sciences research and occupies a marginal space in terms of methodological legitimacy. We highlight the value of paying attention to the ways in which participants speak back to the researcher. This paper draws on marginalia found in surveys written or drawn by young people in classrooms across South Wales, demonstrating how various notes and marks made spontaneously by participants can tell us something important and worthwhile about how young people engage with research. We position marginalia as a manifestation of complex power dynamics in the research process that illuminate participants’ negotiation of complex and multiple subjectivities in the literal margins and between the lines of the survey pages. Whilst the sensitive and rigorous analysis of marginalia is fraught with ethical and methodological challenges, we argue that paying closer attention to marginalia presents an opportunity for deeper engagement with participants when undertaking survey research.     

Promising practices and strategies for using trauma-informed child welfare practice to improve foster care placement stability: a breakthrough series collaborative

This paper will provide information on a recent Breakthrough Series Collaborative (BSC) conducted by the National Child Traumatic Stress Network on Using Trauma-Informed Child Welfare Practice to Improve Foster Care Placement Stability. Information on this particular BSC will be provided, followed by initial findings gathered from an evaluation of the BSC and metrics gathered by each of the nine participating teams throughout the BSC process. Specific trauma-informed promising strategies adopted by teams are presented along with recommendations for next steps.     

“When the money's low”: Economic participation among disadvantaged young Australians

As a generational group, children and young people are rarely independent financial actors but are nonetheless active consumers of goods and services related to their social identities and enduring orientations to learning, work and community. Many young Australians, however, do not have adequate access to the financial resources that permit their engagement with youth cultures constructed around commodity consumption nor with services and activities that support their future workforce and civic participation. Furthermore, they negotiate this lack of provision in an overarching political climate that individualises responsibility for disadvantage and its outcomes. This paper draws on stories from over 70 young Australians (11-17) to illustrate how they experience and manage the economic demands of family, schooling and peer cultures. Their accounts add to the growing literature that demonstrates how young people mobilise material and discursive resources but also points to the need for social policy that addresses the multiple material, social, discursive and institutional barriers to their full social inclusion.     

MORE MISSING WOMEN,FEWER DYING GIRLS: THE IMPACT OF SEX‐SELECTIVE ABORTION ON SEX AT BIRTH AND RELATIVE FEMALE MORTALITY IN TAIWAN

This study finds that the introduction of sex‐selective abortion in Taiwan due to the legalization of abortion when prenatal sex‐detection technology was already available increased the fraction of males born at higher parities and changed the composition of mothers choosing to give birth. Controlling for compositional changes, we find that access to sex‐selective abortion reduced relative neonatal female mortality rates for higher‐parity births.     

大学生学习环境乐趣量表编制:方法与原则

本研究依据工作场所乐趣的相关理论,研拟讨论问题,透过大学生深入访谈,厘清大学生学习环境乐趣量表的各个因素与问题,并针对大学生问卷调查进行探索性因素分析与二阶验证性因素分析.研究结果表明,大学生学习环境乐趣量表可分三大因素:同侪互动、环境乐趣营造、学习气氛,量表具有良好的结构效度和效标关联效度,各项指针显示具有较好的稳定性和一致性.     

Assessing local capacity for health intervention

Because of their location within the practice realm, participatory, community-based public health coalitions offer many lessons about implementing and sustaining local interventions. This paper presents a case study of capacity assessment at the local level. Capacity evaluation methods are presented, with emphasis on the theoretical framework used to guide the evaluation. The capacity evaluation framework presented herein was theoretically based and designed to generate practical information to facilitate the adoption of a locally tailored youth obesity prevention program, VERB Summer Scorecard (VSS). Using multiple methods, four aspects of community capacity were assessed, including community, knowledge and skills, resources, and power. Within each category, factors that facilitated or impeded program implementation were distinguished. The evaluation protocol was designed to generate information increasing community capacity to sustain a community-based obesity prevention program. Capacity tables were used as a program-planning tool and as a system for sharing implementation and sustainability requirements with potential adopters. This case study also explores how to use capacity assessment results to empower coalitions to serve as catalysts for development of local programs in other communities.     

Gerontological Competencies among MSW Students: Evaluation of a Gerontology Specialization Program

ABSTRACT

The purpose of this study was to conduct a preliminary evaluation of a gerontology specialization program (GSP) within a Council on Social Work Education (CSWE)–accredited master of social work (MSW) program. This study utilized a pretest/posttest design with a three-group comparison: group 1—GSP students; group 2—students from the group 1 program but not in GSP; and group 3—students at two external MSW programs with no GSPs. The overall sample comprised 220 advanced year students. A CSWE Gero-Ed Center/Hartford Partnership empirical measure was used to assess overall, gero social work practice competency. Within-group analyses revealed a significant increase in gero competency scores from pretest to posttest among all groups, with GSP students showing the largest increase. Between-group analysis at pretest revealed that the GSP group showed lower gero competency scores than both non-GSP groups. At posttest, these results overturned: GSP students scored significantly higher gero competency scores than both non-GSP groups. These preliminary findings suggest that the GSP offers an impactful, positive role in development of practice skills for the next generation of gero social work practitioners and scholars. A follow-up study with additional years of data will increase longitudinal rigor and confidence in the long-range efficacy of this GSP.     

Vocational Identity Resources in Emerging Adulthood: Associations With Facets of Dispositional Mindfulness

The processes of career development and forming a crystallized identity can be fraught with emotional turmoil. One multidimensional construct known to reduce emotional reactivity is dispositional mindfulness (DM). We used canonical correlation analysis to examine relationships involving measures of resources for establishing a vocational identity (Hirschi, 2012a) and facets of DM in emerging adults (134 women, 38 men). Observing, describing, and nonreactivity to inner experiences contributed uniquely to the first canonical function with career agency and occupational engagement. Observing, describing, and nonjudging contributed uniquely to the second function with occupational engagement and negative career outlook. These results shed light on key facets of DM that help emerging adults to effectively utilize emotion within the context of career‐life planning. Future research should examine relationships between DM facets and additional constructs subsumed within the career resources model. Counselors may find utility in understanding how clients conceptualize conscious emotional experience and use it in career‐life planning.