Motivated by a breast cancer research program, this paper is concerned with the joint survivor function of multiple event times when their observations are subject to informative censoring caused by a terminating event. We formulate the correlation of the multiple event times together with the time to the terminating event by an Archimedean copula to account for the informative censoring. Adapting the widely used two-stage procedure under a copula model, we propose an easy-to-implement pseudo-likelihood based procedure for estimating the model parameters. The approach yields a new estimator for the marginal distribution of a single event time with semicompeting-risks data. We conduct both asymptotics and simulation studies to examine the proposed approach in consistency, efficiency, and robustness. Data from the breast cancer program are employed to illustrate this research.
This paper aims at discussing some contributions, limitations and opportunities that efficiency and equity studies could make to form a better understanding of ethical issues involved in health technology assessment (HTA). Prenatal detection of Down syndrome is used as a case study for further discussions regarding efficiency and equity, as well as other ethical principles including beneficence, non-maleficence and autonomy. The development and use of adequate methods and the need for context appraisal are two imperative issues in this field of knowledge. The analysis of ethical implications in HTA should account for both. Economic evaluation methodologies have great potential in the assessment of some key ethical principles such as efficiency and equity but are of limited use concerning other fundamental principles. Social and individual values play a prominent role in this respect. 相似文献
This paper studies a single-product distribution channel where a supplier manufactures items of a given type, some of which are defective, that are sold by a retailer who only detects a subset of the defective items, passing the rest along to customers. We conjecture the structure of the demand and cost functions, assuming customers to have a decreasing marginal aversion to bad quality while both the supplier and the retailer make marginally increasing efforts to avoid bad quality. This allows us to deduce several implicit parameters of a cost model based on observable data, such as the share of the channel margin. Once the parameters of the model are available, we analyze the result of vertical integration. Although we confirm the well-known fact that vertical integration improves the quality perceived by the customer, we characterize the supplier's decision of whether or not to provide a better quality in terms of the individual channel margins. As an alternative, we derive the conditions under which the supplier and the retailer may devise a mutually beneficial transfer contract that simultaneously increases their profit and improves quality. 相似文献
AIDS education started very early in Zimbabwe and is now compulsory in all schools. This evaluation documents the development of the primary and secondary school AIDS Action Programme from 1991 to 1998. Six programme aspects were evaluated: programme start-up, planning and management, development of syllabi and materials, teacher training, research, monitoring and evaluation, and co-ordination. The Programme drew on resources from within the existing educational system. Due to broad-based consultation and participation, it was supported by Government and partners. Flexible management ensured implementation of mid-course corrections. It was concluded that school AIDS programmes should stress participatory teaching and learning methods and life-skills training. Curriculum writers and teachers needed training and supervision in participatory techniques. Cluster workshops between district and school levels were needed to strengthen the cascade model of teacher training that had been adopted. Systematic research, monitoring and evaluation were essential, including follow-ups to baseline surveys. The Zimbabwean programme was well-designed, relatively inexpensive and replicable. 相似文献
To examine flexible work scheduling of married workers a conceptual framework was developed and tested using the 1997 Current Population Survey Work Schedules Supplement. Odds of flextime use were higher for married males, non-Hispanic whites, those with relatively higher levels of education and income, those with a preschool aged child, residents of the Midwest or West (as compared with the South), managers or professionals, and employees of the federal government. 相似文献
This study examines the relationship between occupational status and fertility timing during a period of rapid development in Puerto Rico. Our fundamental hypothesis is that women with higher status occupations face greater opportunity costs than those with less valued jobs and therefore will be more likely to postpone parenthood until later ages than women without such high costs. We test this hypothesis using event history techniques with data from the 1982 Puerto Rico Fertility and Family Planning Assessment, an island-wide survey of women between the ages of 15 and 49. The analysis examines the effects of occupational status on the timing of first births, and finds strong support for the basic hypothesis, especially regarding the post-ponement of teen births. After the teen years, the effects are less pronounced. Overall, it appears that employment opportunities have played an important role in childbearing decisions in Puerto Rico.An earlier version of this paper was presented at the annual meeting of the Population Association of America, Denver, Colorado, 30 April–2 May 1992. 相似文献
The purpose of this paper is threefold. First, we obtain the asymptotic properties of the modified model selection criteria proposed by Hurvich et al. (1990. Improved estimators of Kullback-Leibler information for autoregressive model selection in small samples. Biometrika 77, 709–719) for autoregressive models. Second, we provide some highlights on the better performance of this modified criteria. Third, we extend the modification introduced by these authors to model selection criteria commonly used in the class of self-exciting threshold autoregressive (SETAR) time series models. We show the improvements of the modified criteria in their finite sample performance. In particular, for small and medium sample size the frequency of selecting the true model improves for the consistent criteria and the root mean square error (RMSE) of prediction improves for the efficient criteria. These results are illustrated via simulation with SETAR models in which we assume that the threshold and the parameters are unknown. 相似文献
Sex differences in expressiveness are well documented, but the reasons for and correlates of these important differences are not well studied. A comprehensive set of emotion-relevant personality measures was administered to 40 female and 39 male undergraduate participants, who were also videotaped in three situations: engaging in natural social interaction, describing a past emotional experience, and posing various emotions. Videotapes were judged by sets of naive observers as to emotion communicated and overall impression. Expressive females, who appeared friendly and dominant in social interaction, were found to have a hostile/aggressive personality (but this was not true of males). Expressive females also tended to look angry/disgusted when describing happy and sad experiences. The findings suggest that nonverbally skilled, charismatic women (but not men) may often possess a dominant/aggressive but self-controlled personality, in a new twist on the theory that sex differences in expressiveness result in part from the oppression of women in society.This research was supported in part by an intramural research grant from University of California, Riverside. 相似文献
‘Gender and organizations’, a fruitful connection between two previously separate areas of study, has had a relatively short but bountiful history. Much of the research and theorizing within the general rubric of ‘gender and organizations’ has required the breaking of conceptual boundaries and the forging of new connections that go beyond the coalescence of two fields of inquiry. We have not exhausted the possibilities suggested by broken boundaries and new connections. This may be a particularly auspicious time to be breaking boundaries, for the apparent worldwide changes in work and organizing are not well enough understood with many of our old intellectual tools. In this paper I discuss briefly what our studies of gender and organization have, in my view, accomplished so far, and then review some issues and questions stimulated by thinking about broken boundaries and new connections, possibilities that, for me, represent part of the future for ‘gender and organizations.’ 相似文献