Longitudinal assessment of the impact of multiple switches between a biosimilar and its reference product on efficacy parameters

Patients, physicians, and health care providers in Europe have more than 10 years of experience with biosimilars. However, there are still debates if switching between a biosimilar and its reference product influences the efficacy of the treatment. In this paper, we address this uncertainty by developing a formal statistical test that can be used for showing that switching has no negative impact on the efficacy of biosimilars. For that, we first introduce a linear mixed‐effects model that is used for defining the null hypothesis (switching influences the efficacy) and the alternative hypothesis (switching has no influence on the efficacy). Using this as the foundation of our work, we propose several approaches for testing for changes in the efficacy of the treatment due to switching and discuss the properties of these tests in an extensive simulation study. It is shown that all these methods have advantages and disadvantages and the decision regarding which method is preferred depends on the expectation of a switching assessment. To demonstrate the applicability of the methods in practice, the approaches were applied to the data of the EGALITY study, which compares the reference product Enbrel® (Amgen) with the approved biosimilar Erelzi® (Sandoz).     

Agenda Setting,Public Opinion,and the Issue of Immigration Reform*

Objective. Agenda‐setting theory is used to motivate hypotheses about how media coverage of immigration influences public perceptions of its importance. The authors seek to offer a more complete explanation of public opinion on immigration by exploring differences in the effects of immigration news in border and nonborder states. Method. This article employs content analyses of newspaper coverage of immigration and Gallup public opinion data over a 12‐month period (January–December 2006). Respondents' identification of immigration as a “Most Important Problem” is modeled as a conditional relationship between border state/nonborder state residence and media coverage, ethnic context, and individual‐level demographics. Results. Media attention to immigration is greater in border states than in nonborder states; as a result, residents of border states are more likely to identify immigration as a most important problem than are residents of nonborder states. Conclusions. The analyses point to the importance of geography and news coverage in explanations of public opinion on immigration.     

Women's Critical Responses to Sexually Explicit Material: The Role of Hyperfemininity and Processing Style

Previous research on women's responses to male-targeted sexually explicit material (SEM) suggests that women may be critical toward such content. However, women's critical responses to SEM have not been explained empirically. The present study had two goals: (1) to investigate whether women's critical responses to male-targeted SEM depend on individual differences in gender role orientation (i.e., hyperfemininity) and (2) to explain the effect of hyperfemininity on critical responses to SEM by looking at the way sexual material is processed. In an online experiment among women aged 18 to 30 (N = 195), both the type of SEM (a male- versus female-targeted erotic story) and processing style (stimulus- versus response-focused) were manipulated. In addition, participants were divided into three groups based on low, moderate, or high hyperfemininity. When using stimulus-focused processing (i.e., attending to the characters and situational context of the story), women were more critical toward male-targeted SEM (relative to female-targeted material), but only when they had low and moderate degrees of hyperfemininity.     

‘Do you really want me to tell ya!’ critical learning in engaging young people in contact with the justice system as peer educators with social work students

ABSTRACT

This paper outlines and evaluates an active and experiential learning project, which gave young people involved with the justice system, a voice as peer educators engaging with social work students outside of the traditional educational institution. The project had two key interconnecting elements. Firstly, by engaging a hidden population of young people in a realistic and meaningful way, it enabled them to share their experiences, and allowed students to understand the complexity of what it means to be socially excluded. Secondly, through this active participation process the young people began to see education as a desirable goal.

The project took place over three months and included 10 social work students and 13 young people involved with the justice system. Creative use of multimedia facilitated production of a learning resource to capture the young people’s lived experiences with statutory social work and justice systems. Young people were fundamentally challenged in their beliefs about themselves being involved in education to achieve a qualification. Students were challenged in their creativity and versatility responding to the task, when collaborating with ‘hard to reach’ young people. They were furthermore challenged in terms of their attitudes and assumptions in relation to offending and social justice.     

Utopian thought: Re-visioning gender,family, and community

Utopian ideals are vital to sustained engagement in the struggle to create a better society. However, the problematic aspects of utopian traditions also need to be addressed as part of the work of social movements. This paper offers a framework for exploring the interplay of healthy and pathological forms of idealization in groups and for analyzing the non-rational dimensions of group life. In critiquing communitarian thought, the paper develops a socialist— feminist and psychoanalytic perspective focusing on the connections between family, sexuality, and democratic community. The paper concludes with political strategies for grounding utopian ideals in contemporary struggles for reform. Les visions d'utopie jouent un rôle très important dans les mouvements visant àfaire une transformation sociale. Pourtant, dans ces projets tranformatifs, il faut aussi tenir compte des aspects les plus problématiques des traditions utopiques. Dans cet article, les auteurs proposent une stratégie pour l'exploration de l'effet réciproque des formes d'idéalisation saines et pathologiques et pour analyser les aspects non-raisonnables en la vie des groupes sociales. En critiquant les idées des ‘communitarians’, une perspective socialist—feministe et psychoanalytique est présentée qui met au centre de l'analyse les rapports entre la famille, la sexualité et la communautédemocratique. Pour conclure, on propose quelques stratégies politiques pour intégrer des idéales utopiques dans les luttes actuelles pour la réforme.     

Should failure to protect laws include physical and emotional sibling violence?

Physical and emotional sibling violence is a problematic occurrence for many children, adults, and families, yet this form of violence rarely falls within the purview of state laws and policies. Failure to protect laws offer one avenue through which sibling violence can be addressed by holding parents and caregivers accountable for harm that occurs to a child in their custody. This article provides background information on physical and emotional sibling violence as well as a general overview of failure to protect laws in the context of intimate partner violence with particular consideration of these laws in addressing sibling violence. In addition, the role social work practitioners can play in intervening and addressing sibling violence through psychoeducation leading to policy (i.e., failure to act laws) is presented.     

The Mentoring FAN: A Promising Approach to Enhancing Attunement within the Mentoring System

ABSTRACT

Youth mentoring is a popular tool in positive youth development, with most programs utilizing a model through which youth and non-parental adults are “matched.” Using an adaptation of the Facilitating Attuned Interactions framework, this study sought to explore the effectiveness of the Mentoring FAN in enhancing interpersonal attunement among mentoring staff at two youth mentoring programs in the U.S. Upon completion of the Mentoring FAN training, quantitative (n = 28) and qualitative (n = 15) data were collected from program staff at both sites. Open-ended data from a subset of mentors (n = 27) was also gathered. Results revealed that mentoring staff experienced significant increases in empathy following the Mentoring FAN intervention. Participant interviews revealed increased attunement, increased listening ability, and increased collaboration in the supervisory relationship. Findings support the continued delivery and rigorous testing of Mentoring FAN training, with great promise for enhancing attunement across the mentoring system as a means of strengthening the relationships so critical to this intervention. The study also has important implications for the development of mentor support practices within mentoring organizations, as well as policies designed to meet the needs of youth served by mentoring programs in the U.S.     

Social workers' attitudes towards the unemployed in the Nordic countries

Kallio J, Blomberg H, Kroll C. Social workers' attitudes towards the unemployed in the Nordic countries In recent decades, municipal social workers have become the implementers of new types of social policy measures aimed at activating the unemployed. These policies put a greater emphasis on the individual's own responsibility for being unemployed. Little is known, however, about how social workers view the unemployed – one factor that might influence how policies are in fact implemented. Therefore, our purpose was to analyse Nordic social workers' attitudes towards the unemployed and their determinants: Do social workers' attitudes correspond with a more individualistic view on unemployment? We utilised the data from surveys of professional social workers in four Nordic countries. Our analyses showed that individualistic attitudes towards the unemployed appeared to be rather rare among Nordic social workers. However, attitudinal differences were found between and within countries.     

争议之地：无家可归者与亚特兰大市中心公园

在此项研究中,我们调查了公园利益相关方超过20年控制无家可归者在市中心公园活动规模的举措,以及无家可归拥护者对付这些举措的一系列回应。我们发现,伍德拉夫公园的用途和价值伴随一天的不同时间、一周的不同日子和不同季节而变化。此外,公园利益相关方虽会随时间而变更,但当局使用的策略不一定必然会朝着某个始终如一的方向发展,或者按一种常规模式变化。最终,虽然无家可归的拥护者比起过去已很少看到,但他们仍然保护了公园内的无家可归者。案例研究认为,一个公园应该是一个基础空间,即作为共有地向所有人开放;也应该是一个典范空间,在这里,没有人会被看作是入侵者。