A simple two-stage design for quantitative responses with application to a study in diabetic neuropathic pain

Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail.     

Bayesian model comparison for compartmental models with applications in positron emission tomography

We develop strategies for Bayesian modelling as well as model comparison, averaging and selection for compartmental models with particular emphasis on those that occur in the analysis of positron emission tomography (PET) data. Both modelling and computational issues are considered. Biophysically inspired informative priors are developed for the problem at hand, and by comparison with default vague priors it is shown that the proposed modelling is not overly sensitive to prior specification. It is also shown that an additive normal error structure does not describe measured PET data well, despite being very widely used, and that within a simple Bayesian framework simultaneous parameter estimation and model comparison can be performed with a more general noise model. The proposed approach is compared with standard techniques using both simulated and real data. In addition to good, robust estimation performance, the proposed technique provides, automatically, a characterisation of the uncertainty in the resulting estimates which can be considerable in applications such as PET.     

A fast algorithm for non-negativity model selection

An efficient optimization algorithm for identifying the best least squares regression model under the condition of non-negative coefficients is proposed. The algorithm exposits an innovative solution via the unrestricted least squares and is based on the regression tree and branch-and-bound techniques for computing the best subset regression. The aim is to filling a gap in computationally tractable solutions to the non-negative least squares problem and model selection. The proposed method is illustrated with a real dataset. Experimental results on real and artificial random datasets confirm the computational efficacy of the new strategy and demonstrates its ability to solve large model selection problems that are subject to non-negativity constrains.     

In Search of the Optimum Harvey Wallbanger Recipe via Mixture Experiment Techniques

A Harvey Wallbanger is an alcoholic drink composed of three ingredients: orange juice, vodka, and Galliano. One of the authors (Sahrmann), a connoisseur of the libation, was perplexed upon discovering that different bartender handbooks listed different recipes for the drink. Determined to shed some light on this irksome problem, he issued invitations for an evening workshop session (party) to former and current attendees of an experimental-design training course taught within his company. A mixture experiment was designed and data collected using the class participants. This article describes the experimental design and the analysis of the data. The results of the experiment indicate that reducing the proportion of vodka produces better-flavored drinks. The results of the experiment were not entirely conclusive, however, so recommendations are made for future experimentation.     

Dynamic Graphics for Exploring Spatial Data with Application to Locating Global and Local Anomalies

We explore the application of dynamic graphics to the exploratory analysis of spatial data. We introduce a number of new tools and illustrate their use with prototype software, developed at Trinity College, Dublin. These tools are used to examine local variability—anomalies—through plots of the data that display its marginal and multivariate distributions, through interactive smoothers, and through plots motivated by the spatial auto-covariance ideas implicit in the variogram. We regard these as alternative and linked views of the data. We conclude that the most important single view of the data is the Map View: All other views must be cross-referred to this, and the software must encourage this. The view can be enriched by overlaying on other pertinent spatial information. We draw attention to the possibilities of one-many linking, and to the use of line-objects to link pairs of data points. We draw attention to the parallels with work on Geographical Information Systems.     

Disabled Persons Support: The Serial Literature

Abstract

The authors anticipate that the primary use of this analysis will be to demonstrate journal price fluctuations by discipline and country of origin to department heads, university and hospital administrators, and others concerned (or who should be concerned) with the costs of health information. The authors expect to repeat this study on an annual basis and would welcome any comments.     

An algorithm for the minimum sum of weighted absolute errors regression

We propose an algorithm to estimate the unknown constants in a multiple linear regression model under the minimum sum of weighted absolute errors (MSWAE). The proposed algorithm, a generalization of an earlier algorithm, is compared to a bounded variable algorithm. Some somputational experience is reported.