Identifying the most successful dose (MSD) in dose-finding studies in cancer

For a dose finding study in cancer, the most successful dose (MSD), among a group of available doses, is that dose at which the overall success rate is the highest. This rate is the product of the rate of seeing non-toxicities together with the rate of tumor response. A successful dose finding trial in this context is one where we manage to identify the MSD in an efficient manner. In practice we may also need to consider algorithms for identifying the MSD which can incorporate certain restrictions, the most common restriction maintaining the estimated toxicity rate alone below some maximum rate. In this case the MSD may correspond to a different level than that for the unconstrained MSD and, in providing a final recommendation, it is important to underline that it is subject to the given constraint. We work with the approach described in O'Quigley et al. [Biometrics 2001; 57(4):1018-1029]. The focus of that work was dose finding in HIV where both information on toxicity and efficacy were almost immediately available. Recent cancer studies are beginning to fall under this same heading where, as before, toxicity can be quickly evaluated and, in addition, we can rely on biological markers or other measures of tumor response. Mindful of the particular context of cancer, our purpose here is to consider the methodology developed by O'Quigley et al. and its practical implementation. We also carry out a study on the doubly under-parameterized model, developed by O'Quigley et al. but not     

Child support and non-resident fathers’ contact with their children

The paper presents a model of a non-resident father’s child support and contact with his child, which combines the public good treatment of “child quality” with “trade” in father–child contact time in a setting of non-cooperative interaction. It predicts that father’s income and mother’s non-labour income should have exactly the same effect on the frequency of father–child contact if he chooses to make lump sum payments to the mother. If he does not or there is a binding child support payment order, they have effects opposite in direction. A higher binding support order reduces father–child contact but may well raise “child quality”.

Immigration: Not a Solution to Problems of Population Decline and Aging

Population and Environment - This article is a synopsis of a UN study, with emphasis on Italy and the United States. In March, 2000, the United Nations Population Division published a 143-page...     

Net migration and migration effectiveness: A comparison between Australia and the United Kingdom, 1976–96

This paper explores the impact of net migration in Australia and the United Kingdom using measures of migration effectiveness computed from period-age migration data for four consecutive five-year periods. Results reported in Part 1 of this paper (Stillwellet al. 2000) suggest that while the overall effectiveness of net migration at the scale of city regions has declined over the twenty-year period in both countries, important geographical variations are evident. Part 2 considers how patterns of migration effectiveness vary by age and presents a single classification of all the city regions on the basis of age-specific effectiveness. More detailed analysis includes spatial patterns for particular age groups and net migration profiles of selected regions. Cohort effects are shown to be important for explaining changes between time periods in these regions.     

Sociological Factors Affecting Agricultural Price Risk Management in Australia*

Abstract The highly volatile auction system in Australia accounts for 85 percent of ex‐farm wool sales, with the remainder sold by forward contract, futures, and other hedging methods. In this article, against the background of an extensive literature on price risk strategies, we investigate title behavioral factors associated with producers' adoption of price risk‐management strategies (specifically futures and forward contracts) for selling wool. This research presents a behavioral model based on Diffusion of Innovations, the Theory of Reasoned Action, and the Theory of Planned Behavior. We found that the auction system is used as a price risk‐management tool because other selling methods are considered more risky. We also report on a curious relationship between risk and complexity in terms of wool producers' intentions to use forward contracts. We explored sociological factors in conjunction with focus‐group data in an attempt to understand this relationship. This exercise yielded some interesting findings on the impact that trust, habit, social cohesion, and networks have on decision making in the rural community. The significance of this article lies in its application of core sociological theory in a new research context: the Australian wool industry.     

Increasing Vocal Variability in Children with Autism Using a Lag Schedule of Reinforcement

Variability has been demonstrated to be an operant dimension of behavior (Neuringer, 2002; Page & Neuringer, 1985). Recently, lag schedules have been used to demonstrate operant variability of verbal behavior in persons with a diagnosis of autism (e.g., Lee, McComas, & Jawor, 2002). The current study evaluated the effects of a Lag 1 schedule on the vocal variability of 2 nonverbal children with a diagnosis of autism. Results showed systematic increases in variability during the Lag 1 schedule. Implications of lag schedules for speech and language training are discussed.     

FOR MONEY OR GLORY? COMMERCIALIZATION,COMPETITION, AND SECRECY IN THE ENTREPRENEURIAL UNIVERSITY

Scholars have grown concerned that the commercialization of academic science is increasing secrecy at the expense of cooperation and information sharing. Using data from comparable surveys of academic scientists in three fields (experimental biology, mathematics, and physics), we test whether scientists have become more competitive and more secretive over the last 30 years. We also use the recent survey to test a multivariate model of the effects of scientific competition and commercialization (patenting, industry funding, and industry collaboration) on scientific secrecy. We find that secrecy has increased, and has increased particularly for experimental biologists. Only 13 percent of experimental biologists in 1998 felt safe discussing their ongoing research with all others doing similar work. Our multivariate analysis shows that this secrecy is most related to concerns about being anticipated (scientific competition). We find that patenting is associated with increased secrecy among mathematicians and physicists, but not for experimental biologists. We find that industry funding is associated with more secrecy, while industry collaboration is associated with less secrecy, across fields. Our results suggest that the recent concern over increasing scientific secrecy has merit. However, this increased secrecy seems to result from a combination of increasing commercial linkages and increased pressures from scientific competition. Our research highlights the central role that scientists' competition for priority plays in the system of science and that, while such competition spurs effort, it also produces negative effects that recent trends toward commercialization of academic science seem to be exacerbating.     

Activity transitions in the homoeopathic therapeutic encounter

Homoeopathy is one of the most widespread forms of complementary and alternative medicine (CAM) currently used in the UK. As an overtly holistic discipline, the homoeopathic consultation process is often regarded as being intrinsically patient-centred. This paper will argue that although an underlying mutualistic or collegial approach is often evident in homoeopathy, there are certain points in a consultation where these types of behaviour are more overt. It is suggested that these points are likely to be located where there is a predictable possibility of misalignment between letting the patient set the agenda, and the practical needs of the consultation process – ie the performance of certain essential consultation 'tasks'. In order to illustrate this, one particular aspect of the homoeopathic consultation will be examined – the 'treatment-giving' phase. Four broad transitional formats will be proposed: categorical ; open ; deferred ; and reversed . The relatively dynamic sequential positioning that the treatment phase occupies in the homoeopathic context will be highlighted, as will the implications that this may have in terms of encouraging patient / practitioner negotiation over treatment decisions.     

How Sunday, price, and social norms influence donation behaviour

We describe a natural field experiment investigating donation behaviour. The setting was an art gallery where donations could be deposited into a transparent box in the foyer. Two aspects of the donation environment were manipulated: signs on the donation box and the initial contents of the box. We used three sign treatments: a control with no sign, a sign that thanked donors, and a sign that indicated donations would be matched. We used two initial contents treatments: one with relatively little money ($50) and one with four times as much. The average donation per donor was significantly larger in the $200 treatments but this was offset by a decrease in the propensity to donate. In the matching treatments donations were significantly larger both at the per donor and per visitor level. A control variable turned out to have the largest influence on donation behaviour: the day of the week. The average donation per visitor was 51% higher on Sundays, when compared to every other day of the week.     

The Politics of Women's Economic Independence

We identify the political conditions that shape the economicposition of married/cohabiting women and of the economicallymost vulnerable group of women—single mothers. Specifically,we examine the determinants of reductions in single mothers'poverty rate due to taxes and transfers, and women's wages relativeto spouses'/ partners' wages. The Luxembourg Income Study archiveyields an unbalanced panel with 71 observations on 15 countries.The principal determinants of poverty reduction due to taxesand transfers are left government, constitutional veto points,and welfare generosity. The relative wage of women in couplesis a function mainly of female labor force participation, parttime work among women, and women's mobilization. In explainingthe causal pathways to these outcomes, we highlight the interrelationshipsof welfare state, care, and labor market policies.