An evaluation of the use of diaries in a study of medication in later life

This paper is based upon our experience of commissioning diaries to be kept by research subjects. First the paper reviews some previous research based on diaries, then it outlines the aims of our research and the method of data collection. Then the paper goes on to evaluate the design and use of a diary that participants in our research completed. In particular we consider the ways in which the diary may have biased our sample, caused the participants difficulties and generated poor data. There is also a discussion on how it may have affected behaviour and on the ethical issues that are raised by commissioned diaries. In conclusion, observations are made about the strengths and weaknesses of diaries as an investigative tool with a wider applicability. The diary proved particularly revealing and we recommend that other researchers consider diaries as a method of investigating everyday life.     

Randomized nomination sampling for finite populations

We propose a randomized minima–maxima nomination (RMMN) sampling design for use in finite populations. We derive the first- and second-order inclusion probabilities for both with and without replacement variations of the design. The inclusion probabilities for the without replacement variation are derived using a non-homogeneous Markov process. The design is simple to implement and results in simple and easy to calculate estimators and variances. It generalizes maxima nomination sampling for use in finite populations and includes some other sampling designs as special cases. We provide some optimality results and show that, in the context of finite population sampling, maxima nomination sampling is not generally the optimum design to follow. We also show, through numerical examples and a case study, that the proposed design can result in significant improvements in efficiency compared to simple random sampling without replacement designs for a wide choice of population types. Finally, we describe a bootstrap method for choosing values of the design parameters.     

Classical multilevel and Bayesian approaches to population size estimation using multiple lists

One of the major objections to the standard multiple-recapture approach to population estimation is the assumption of homogeneity of individual 'capture' probabilities. Modelling individual capture heterogeneity is complicated by the fact that it shows up as a restricted form of interaction among lists in the contingency table cross-classifying list memberships for all individuals. Traditional log-linear modelling approaches to capture–recapture problems are well suited to modelling interactions among lists but ignore the special dependence structure that individual heterogeneity induces. A random-effects approach, based on the Rasch model from educational testing and introduced in this context by Darroch and co-workers and Agresti, provides one way to introduce the dependence resulting from heterogeneity into the log-linear model; however, previous efforts to combine the Rasch-like heterogeneity terms additively with the usual log-linear interaction terms suggest that a more flexible approach is required. In this paper we consider both classical multilevel approaches and fully Bayesian hierarchical approaches to modelling individual heterogeneity and list interactions. Our framework encompasses both the traditional log-linear approach and various elements from the full Rasch model. We compare these approaches on two examples, the first arising from an epidemiological study of a population of diabetics in Italy, and the second a study intended to assess the 'size' of the World Wide Web. We also explore extensions allowing for interactions between the Rasch and log-linear portions of the models in both the classical and the Bayesian contexts.     

Do antidepressants work? Statistical significance versus clinical benefits

Ours has been called the Prozac generation but, earlier this year, newspaper front page headlines screamed Antidepressants don't work. Our authors' reanalysis of drug trials was widely reported as implying that antidepressant drugs such as Prozac are overprescribed and useless. The truth, as Blair T. Johnson and Irving Kirsch explain, is more complex, and more interesting.     

Tables to facilitate fitting lu distributions

This paper is concerned with estimating the parameters of Tadikamalla-Johnson's L_Udistributions based on the method of moments. Tables of the parameters of the L_U distribution are given for selected values of skewness (0.0(0.05) 1.0(0.1)2.0) and for twenty values of kurtosis at intervals of 0.2. The construction and use of these tables is explained with a numerical example.     

A comparison of estimators of the degree of insect control

The current estimator of the degree of insect control by an insecticide in a field experiment laid out in randomized blocks is equal to one minus the cross-product ratio of a two way table of total insect counts over blocks. Since much work has been done on estimation of the common odds ratio of a number of strata in medical studies, a series of Monte Carlo studies was performed to investigate the possible use of these estimators and their standard errors in estimating the common degree of inject control of a number of blocks. Maximum likelihood, Mantel-Haenszel, and empirical logit estimators were evaluated and compared with back-transformed means over blocks, of cross-product ratios on the arithmetic, logarithmic, and arcsine scales. Maximum likelihood and Mantel-Haenszel estimators had the smallest mean squared errors, but their standard error estimates were only appropriate when sampling distributions were approximately Poisson and there was little heterogeneity among plots within blocks in the natural rates of population change.     

Asymptotic distributions for quadratic forms with applications to censored data tests of fit

We obtain the asymptotic distributions of certain forms in observations that are possible Type I and Type II censored. This result is directly applicable to the study of asympototic distributions for censored data versions of the Shapiro- wilk test for normality. Moreove, it applies more generally than just to the null hypothesis of normality.     

A nonlinear regression model for describing averaged growth curves of mice

A general four parameter growth curve is presented as a model for the growth curve of a group of mice for which averaged weights of the group are available. Several data sets of mice weights obtained from experiments performed at the National Center for Toxicological Research are analyzed. The results are compared with traditional models for growth curves. Both additive and multiplicative error models are analyzed. It is shown that for this data the four parameter model gives a much better fit than traditional growth curve models and should be given serious consideration in model fitting.     

Letter to the editor the asymptotic distribution of the process capability index cpmk

In theorem 3.1 of Chen and Hsu (1995) an expressin for an upper confidence bound for C_pmk in the case when µ = M and so C_pmk = C_pm, is given as a multiple of C_pm. However, if the value µ = M known then it would be more reasonable to use the estimator obtained by replacing X_n by M.