Utilizing Bayesian predictive power in clinical trial design

The Bayesian paradigm provides an ideal platform to update uncertainties and carry them over into the future in the presence of data. Bayesian predictive power (BPP) reflects our belief in the eventual success of a clinical trial to meet its goals. In this paper we derive mathematical expressions for the most common types of outcomes, to make the BPP accessible to practitioners, facilitate fast computations in adaptive trial design simulations that use interim futility monitoring, and propose an organized BPP-based phase II-to-phase III design framework.     

The Effects of Corporate Elitism and Groupthink on Organizational Empathy in Crisis Situations

This study is to empirically testify that corporate elitism is an antecedent to groupthink, which prevents organizational empathy from working effectively in crises. The current study is expected to expand the boundary of crisis management literature into a company’s crisis-preparedness before a crisis occurs. The findings offer the useful guidance to organizations on how to better manage their crisis proneness through identifying the early signs of corporate elitism and groupthink.     

Likelihood ratio tests for multivariate normality

This paper presents some powerful omnibus tests for multivariate normality based on the likelihood ratio and the characterizations of the multivariate normal distribution. The power of the proposed tests is studied against various alternatives via Monte Carlo simulations. Simulation studies show our tests compare well with other powerful tests including multivariate versions of the Shapiro–Wilk test and the Anderson–Darling test.     

On nonparametric variogram estimation

A critical step for geostatistical prediction is estimation of variogram from the data. One of the popular methods estimating variogram is a smoothed version of classical nonparametric variogram estimator. In this paper we investigate its theoretical and empirical properties to provide useful information for using it. The main results are based on asymptotic theories (i.e., risk and central limit theorem) under nearly infill domain sampling. Simulation is also employed to make our points.     

Maternal Experiences of Parenting Girls who are Perceived as Overweight or at Risk for Becoming So: Narratives of Uncertainty,Ambivalence and Struggle

This work explored U.S. mothers’ experiences of parenting young adolescent girls who are perceived by their mothers as overweight or at risk for becoming so. Data were collected via in‐depth interviews with 13 mothers and were analysed using a constructivist grounded theory approach. Many mothers experienced socializing their daughters about issues of the body, weight, diet, and health as marked by uncertainty, ambivalence and struggle, particularly relative to four subthemes: mothers’ embodiment as challenge to ‘good mothering’, negotiating a dilemma of the ‘healthy mind’ versus the ‘healthy body’, managing discipline: how much to intervene?, and the challenge of interpersonal dynamics.     

The estimation of treatment effect for the censored bivariate data under the univariate censoring

This paper establishes a nonparametric estimator for the treatment effect on censored bivariate data under unvariate censoring. This proposed estimator is based on the one from Lin and Ying(1993)'s nonparametric bivariate survival function estimator, which is itself a generalized version of Park and Park(1995)' quantile estimator. A Bahadur type representation of quantile functions were obtained from the marginal survival distribution estimator of Lin and Ying' model. The asymptotic property of this estimator is shown below and the simulation studies are also given     

Temporal Disaggregation: Methods,Information Loss,and Diagnostics

This research provides a generalized framework to disaggregate lower-frequency time series and evaluate the disaggregation performance. The proposed framework combines two models in separate stages: a linear regression model to exploit related independent variables in the first stage and a state–space model to disaggregate the residual from the regression in the second stage. For the purpose of providing a set of practical criteria for assessing the disaggregation performance, we measure the information loss that occurs during temporal aggregation while examining what effects take place when aggregating data. To validate the proposed framework, we implement Monte Carlo simulations and provide two empirical studies. Supplementary materials for this article are available online.     

An exploratory data analysis in scale-space for interval-valued data

We propose an exploratory data analysis approach when data are observed as intervals in a nonparametric regression setting. The interval-valued data contain richer information than single-valued data in the sense that they provide both center and range information of the underlying structure. Conventionally, these two attributes have been studied separately as traditional tools can be readily used for single-valued data analysis. We propose a unified data analysis tool that attempts to capture the relationship between response and covariate by simultaneously accounting for variability present in the data. It utilizes a kernel smoothing approach, which is conducted in scale-space so that it considers a wide range of smoothing parameters rather than selecting an optimal value. It also visually summarizes the significance of trends in the data as a color map across multiple locations and scales. We demonstrate its effectiveness as an exploratory data analysis tool for interval-valued data using simulated and real examples.     

Development and evaluation of the physical activity questionnaire for elderly Japanese: the Nakanojo study

The Physical Activity Questionnaire for Elderly Japanese (PAQ-EJ) is a self-administered physical activity questionnaire for elderly Japanese; the authors report here on its repeatability and direct and indirect validity. Reliability was assessed by repeat administration after 1 month. Direct validation was based on accelerometer data collected every 4 s for 1 month in 147 individuals age 65-85 years. Indirect validation against a 10-item Barthel index (activities of daily living [ADL]) was completed in 3,084 individuals age 65-99 years. The test-retest coefficient was high (r = .64-.71). Total and subtotal scores for lower (transportation, housework, and labor) and higher intensity activities (exercise/sports) were significantly correlated with step counts and durations of physical activity <3 and >or=3 METs (r = .41, .28, .53), respectively. Controlling for age and ADL, scores for transportation, exercise/sports, and labor were greater in men, but women performed more housework. Sex- and ADL- or age-adjusted PAQ-EJ scores were significantly lower in older and dependent people. PAQ-EJ repeatability and validity seem comparable to those of instruments used in Western epidemiological studies.     

Pathways from workplace flexibility to turnover intention: Role of work–family conflict,family–work conflict,and job satisfaction

This study examined the prevalence of workplace flexibility and the mechanisms that allow workplace flexibility to influence turnover intentions through work–family and family–work conflicts and job satisfaction among low‐wage workers in South Korea. Participants included 250 low‐wage workers whose monthly salary was less than 2 million Korean won (approx. $1,900). The study results indicate that low‐wage workers have limited access to workplace flexibility and that workplace flexibility plays a significant protective role in reducing their turnover intention, indirectly by decreasing work–family conflicts and enhancing job satisfaction. This article also discusses the implications of these findings for labor policy and social work practice.