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11.
Aging in the Era of Regenerative Medicine: Analysis of Aging‐Related Representations among Canadian Researchers 下载免费PDF全文
Céline Lafontaine 《The Sociological quarterly》2015,56(1):62-79
Explicitly aimed at understanding and controlling molecular and cellular processes at the root of senescence and biological aging, regenerative medicine aspires to artificially reproduce the biological processes that enable the body to regenerate itself. This no longer involves conserving the body's state of balance by combating disease, as in clinical medicine, but rather fighting degeneration itself. From stem cell research to gene therapy to the production of replacement tissues, regenerative medicine perfectly corresponds to the logic of biomedicalization specific to postmodern society. Based on a series of 18 interviews conducted with Canadian researchers and clinicians in the field of regenerative medicine, this article seeks to understand representations of the aging body among researchers in this field. Seen from a strictly negative angle, aging is assimilated by researchers to an inevitable catastrophe that nevertheless must be combated. More closely observing the theoretical model of regenerative biology and the types of treatments developed, it can be observed, however, that this medicine of the future does not target the elderly, but rather promises youth the ability to regenerate themselves to avoid aging. 相似文献
12.
Laurent Gardes Stéphane Girard Gilles Stupfler 《Scandinavian Journal of Statistics》2020,47(3):922-949
The conditional tail expectation (CTE) is an indicator of tail behavior that takes into account both the frequency and magnitude of a tail event. However, the asymptotic normality of its empirical estimator requires that the underlying distribution possess a finite variance; this can be a strong restriction in actuarial and financial applications. A valuable alternative is the median shortfall (MS), although it only gives information about the frequency of a tail event. We construct a class of tail Lp-medians encompassing the MS and CTE. For p in (1,2), a tail Lp-median depends on both the frequency and magnitude of tail events, and its empirical estimator is, within the range of the data, asymptotically normal under a condition weaker than a finite variance. We extrapolate this estimator and another technique to extreme levels using the heavy-tailed framework. The estimators are showcased on a simulation study and on real fire insurance data. 相似文献
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María del Carmen Méndez García 《Intercultural Education》2005,16(1):57-68
The sociocultural content of foreign language textbooks has become a concern of scholars and practitioners owing to the fact that the traditional emphasis on purely linguistic issues has been expanded to embrace a language in context approach. This paper studies the English‐speaking communities that are described in English language teaching textbooks marketed in Spain. It examines to what extent an international and/or intercultural approach is a constituent element in their design. 相似文献
15.
Computing maximum likelihood estimates from type II doubly censored exponential data 总被引:1,自引:0,他引:1
Arturo J. fernández José I. Bravo Íñigo De Fuentes 《Statistical Methods and Applications》2002,11(2):187-200
It is well-known that, under Type II double censoring, the maximum likelihood (ML) estimators of the location and scale parameters, θ and δ, of a twoparameter exponential distribution are linear functions
of the order statistics. In contrast, when θ is known, theML estimator of δ does not admit a closed form expression. It is shown, however, that theML estimator of the scale parameter exists and is unique. Moreover, it has good large-sample properties. In addition, sharp
lower and upper bounds for this estimator are provided, which can serve as starting points for iterative interpolation methods
such as regula falsi. Explicit expressions for the expected Fisher information and Cramér-Rao lower bound are also derived.
In the Bayesian context, assuming an inverted gamma prior on δ, the uniqueness, boundedness and asymptotics of the highest
posterior density estimator of δ can be deduced in a similar way. Finally, an illustrative example is included. 相似文献
16.
Conservation biology aims at assessing the status of a population, based on information which is often incomplete. Integrated population modelling based on state‐space models appears to be a powerful and relevant way of combining into a single likelihood several types of information such as capture‐recapture data and population surveys. In this paper, the authors describe the principles of integrated population modelling and they evaluate its performance for conservation biology based on a case study, that of the black‐footed albatross, a northern Pacific albatross species suspected to be impacted by longline fishing 相似文献
17.
Andrée Coulombe M.Ps. Robert Ladouceur Ph.D. Raymond Desharnais Ph.D. Jean Jobin Ph.D. 《Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming》1992,8(3):235-244
This study investigated the relationship between the level of arousal (Heart Rate) and the number of erroneous perceptions among video poker players. Twelve regular and twelve occasional gamblers participated in a gambling session conducted in a natural environment. It was hypothesised that 1) a significant positive correlation would be observed between arousal and the number of erroneous verbalizations, 2) regular players would show a higher level of arousal than occasional players, and 3) they would emit more erroneous verbalizations. Results showed that hypotheses one and three were confirmed. Theoretical and practical implications of these results for the psychology of gambling are discussed.This study was supported by a grant from Loto-Québec. 相似文献
18.
Demographic Shifts in the Czech Republic after 1989: A Second Demographic Transition View 总被引:1,自引:1,他引:0
A dramatic change in fertility,family formation and living arrangements tookplace in the Czech Republic over the 1990s. Theestablishment of democracy, profound socialtransformation and transition to the marketeconomy affected the values and demographicbehaviour of the young Czech generation. Thispaper examines whether these demographic shiftscan be interpreted within the framework of thesecond demographic transition. The theoreticalpart discusses the idea of the transition,outlining three distinctive conceptualisations.Two of them – the view of the transition as aprogression of characteristic interrelateddemographic changes and a broader viewstressing the importance of underlyingideational factors – fit the Czech situationvery well. A comparison with the Netherlandsreveals that the onset of the transition in theCzech Republic may be clearly located in thefirst half of the 1990s, lagging two decadesbehind the Netherlands. 相似文献
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Elisabeth Allès 《Asian Ethnicity》2005,6(2):121-134
Chinese-speaking Muslims, called Dungans in Central Asia and Huizu in China, were forced to migrate to present-day Kazakhstan, Kyrgyzstan and Uzbekistan at the end of the nineteenth century. They reconstructed their identity through interrelations with local populations and the soviet categorisation of nationality. But after 1991, their status has being gradually destabilised owing to the changes in economic, social and political rules as well as citizenship regulations in these countries. They have to readapt to the new situation created by the independence of the three former Soviet Republics, which has challenged their unity. 相似文献