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181.
The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical
data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited
in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory
networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of
many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance
evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient. 相似文献
182.
183.
In order to assess the effectiveness of government programs designed to reduce disparities in the health care minority groups receive relative to the majority white population, a proper statistical measure should be used. This article proposes a measure of and its accompanying graph, which is readily interpretable and is not affected by the number of minority subgroups examined. 相似文献
184.
In this paper, we deal with a discrete-time multiserver retrial queue with finite population. Firstly, we study the Markov chain at the epochs immediately after slot boundaries making emphasis on the computation of its steady-state distribution. Then, the main performance measures are investigated. Besides, we simulate the waiting time of a customer in the retrial group under three different queueing policies. Some numerical examples are given to illustrate the analysis. 相似文献
185.
D. R. Cox 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2003,166(2):241-246
Summary. Possible health hazards from mobile phones arise from the use of the phones themselves and via the base stations that relay signals. Except for an increase in traffic accidents induced by the use of mobile phones in cars the evidence for a health hazard is at most indirect, but it cannot be entirely dismissed; the phones have not been widely used for sufficiently long for direct epidemiological studies to have high sensitivity for detecting any induced incidence of cancer, for example. The background and evidence are briefly reviewed and the steps taken in the UK to make information widely available described. 相似文献
186.
Julia R. Irwin 《Infancy》2003,4(4):503-516
This study examined whether perceivers can detect infant distress in the visual and acoustic signals within the cry. Parent and nonparent perceivers rated distress in 3‐, 6‐, 8‐, and 12‐month‐old infants' cries that were manipulated to separate facial, vocal, and bodily action. Mean perceiver ratings differed for high‐ and low‐distress cries at each infant age on the basis of facial and vocal action, but not bodily movement. Perceivers rated the cry sound as more distressed and the cry face as less distressed with increasing infant age. Parents rated the cries as less distressed overall than did nonparents. The results suggest that information about distress is available for perceivers in the crying infant's face and voice. 相似文献
187.
This paper studies optimum designs for linear models when the errors are heteroscedastic. Sufficient conditions are given
in order to obtainD-, A- andE-optimum designs for a complete regression model from partial optimum designs for some sub-parameters. A result about optimality
for a complete model from the optimality for the submodels is included.
Supported by Junta de Andalucía, research group FQM244. 相似文献
188.
Christopher R. Browning Matisa Olinger‐Wilbon 《Journal of marriage and the family》2003,65(3):730-745
We examine the relationship between neighborhood structural characteristics, social organization, and the sexual partnering practices of adults. Analyses of 1990 census and 1995–1997 survey‐based data on Chicago neighborhoods and adult sexual activity reveal for men a number of neighborhood influences on sexual partnering practices. First, residential stability is negatively associated with having a short‐term sexual partner in the last year. Second, neighborhood social ties are positively associated with short‐term sexual partnering in neighborhoods with low levels of collective efficacy—the combination of cohesion and shared expectations for beneficial action among neighbors—but this effect is substantially reduced as collective efficacy increases. Moreover, neighborhood collective efficacy and social ties mediate the effect of residential stability on sexual partnering practices. Neighborhood characteristics were not associated with short‐term sexual partnering for women. 相似文献
189.
190.
Dwight R. Lee 《Journal of Labor Research》2003,24(3):437-446
Reverse mandated benefits is a government-mandated policy that requires employees to provide their employers with benefits
that workers would not provide otherwise. Of course, only those benefits would be mandated that are worth more to employers
than they cost, as determined by political authorities. My case for such a policy argues that it is at least as sensible as
policies mandating that employers provide benefits to their employees that would not be provided otherwise. 相似文献