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821.
822.
Judith Petts 《Risk analysis》2000,20(6):821-832
Like radioactive waste, municipal solid waste (MSW) requires consideration of a complex mix of intergenerational and intragenerational risks surrounded by uncertain science. Unlike radioactive waste, MSW is a common problem and hence one often perceived to be controllable, at least until a required facility is proposed in a particular community. The intragenerational risks focused on local communities rouse intense public pressures for management. Although some of the risks can be quantified, the risk assessment process cannot deal with all questions. This article examines the multiple dimensions of the decisions required to be made and the weaknesses of a number of decision tools traditionally used. A case is made for the need to integrate decision tools appropriate to the risks into reflexive and iterative decision processes open to public involvement. It is argued that this presents the best hope of both optimizing decisions about the intragenerational risks as well as raising public debate about the importance of sustainable waste management in transgenerational terms. 相似文献
823.
Ivy N. Defoe Judith Semon Dubas Marcel A. G. van Aken 《Journal of research on adolescence》2023,33(2):641-655
This longitudinal two-wave cross-national study investigated whether intentions, friends' substance use, and parent-adolescent substance-use specific communication predict adolescent alcohol and cannabis use 1 year later, while estimating reversed links. The temporal order between these two substances was also examined. We used multi-group cross-lagged panel modeling on data from 2 ethnically and socioeconomically diverse samples: Sint Maarten (N = 350; Mage = 14.19) and the Netherlands (N = 602; Mage = 13.50). Results showed that in the Netherlands, cannabis use predicts more subsequent problems (alcohol use, intention to use cannabis, and affiliation with cannabis-using friends). But for Sint Maarten, alcohol use predicts more subsequent problems (cannabis use, intention to use alcohol, and affiliation with alcohol-using friends). These opposing results demonstrate that caution is warranted when generalizing results across countries. 相似文献
824.
Wei Zhao Paolo Vicini Steven Novick Judith Anderton Gareth Davies Gina DAngelo Terrance O'Day Binbing Yu Jay Harper Rajesh Narwal Lorin Roskos Harry Yang 《Pharmaceutical statistics》2019,18(6):688-699
Linear models are generally reliable methods for analyzing tumor growth in vivo, with drug effectiveness being represented by the steepness of the regression slope. With immunotherapy, however, not all tumor growth follows a linear pattern, even after log transformation. Tumor kinetics models are mechanistic models that describe tumor proliferation and tumor killing macroscopically, through a set of differential equations. In drug combination studies, although an additional drug‐drug interaction term can be added to such models, however, the drug interactions suggested by tumor kinetics models cannot be translated directly into synergistic effects. We have developed a novel statistical approach that simultaneously models tumor growth in control, monotherapy, and combination therapy groups. This approach makes it possible to test for synergistic effects directly and to compare such effects among different studies. 相似文献
825.
This paper reports a nearly two-year intervention with staff at a major urban pediatric facility. The authors worked as trainers and consultants for two groups-the Emergency Department (ED) and Chronic Care units (CC). Following two days of training about grief and loss, highlighting skill building for work with traumatized and grieving children and parents, the consultants worked to develop teams which could provide a Winnicottian holding environment for staff. The efficacy of this staff training is analyzed and support needs of staff members are identified. Findings include varied willingness to make use of group support. Chronic care participants are more likely to express willingness to engage in on-going support for one another, while ED staff members seem to prefer structured, educational training and episodic support. The holding environment of the processing groups must be adapted to fit the needs of the medical sub-culture. 相似文献
826.
This paper focuses on the period in U.S. history that experienced the most rapid rate of increase of church membership—the decades between 1850 and 1930—in order to explain synchronic and diachronic variation in those rates. Using pooled cross-sectional time series analysis, different predictions are derived and tested from theories of secularization/social control, comparative disadvantage, resource mobilization, and pluralism. The effects of spatial diffusion and the momentum of religious tradition also are estimated. Our conclusion is that religious monopoly—not diversity—fuels religious expansion. This finding is bolstered by the complementary result that ethnic homogeneity is also conducive to religious expansion. Together these results highlight the importance for mobilization of religious and ethnocultural dominance in a particular niche. 相似文献
827.
This paper tests predictions of continuity and change in antisocial behavior over time as derived from population heterogeneity and life-course perspectives. These predictions are assessed with respect to a rarely studied form of delinquent/criminal behavior, cocaine use during the late-teenage and young adult years. We first examine the extent to which differential propensities toward antisocial behavior can be detected in a nationally representative sample of youth aged 14-16 in 1979. Based on self-reported delinquent and criminal activities in late adolescense, traditional cross-sectional latent-class analysis identifies three groups of antisocial/rebellious respondents and a group of non-offenders. We then follow these groups into early adulthood, examining age trajectories of cocaine usage between 1984 and 1998. Latent-class trajectory models identify clusters of respondents who show similar age trajectories of cocaine use over time and provide parameter estimates that predict membership in those clusters. In support of the population heterogeneity perspective, we find that antisocial/rebellious youth have higher probabilities of cocaine use throughout early adulthood than non-of-fending youth. There is, however, much variation in drug use patterns among the groups as they aged. In support of a life-course perspective, we find that social ties to schools, families, religion, and the labor market help differentiate youth who refrain from, maintain, or desist from using cocaine through early adulthood. 相似文献