Approximate Small-Sample Tests of Fixed Effects in Nonlinear Mixed Models

Nonlinear mixed effect models have been studied extensively over several decades, particularly in pharmacokinetic and pharmacodynamic applications. Here, we focus on investigating the performance of commonly applied tests of linear hypotheses about the fixed effect parameters under different approximations to the likelihood function and to the estimated covariance matrix of the estimators. Included are the first-order approximation (FIRO), first-order conditional approximation (FOCE), and Gaussian quadrature approximation (AGQ) estimation methods. There is no straightforward way to mimic the approximations and adjustments taken in linear mixed models, such as the Kackar–Harville–Jeske–Kenward–Roger approach. By simulations, we illustrate the accuracy of p-values for the tests considered here. The observed results indicate that FOCE and AGQ estimation methods outperform FIRO. The test with an adjustment coefficient that takes into consideration the number of sampling units and the number of fixed effect parameters (Gallant-type) seems to perform closest to desirable even for small-sample sizes.     

Benchmarks derived from quantitative endpoints - an approach accounting for litter effects

The use of quantitative variables for risk assessment suffers from the lack of a clear-cut definition of risk. The proposals of Chen and Gaylor (1992) and of Kodell and West (1993) showed a way out of this dilemma. Additional risk is defined as the increase in probability of being in an abnormal state for an exposed individual. In this paper we show how this approach can be generalized to situations where an additional source of variability, often called litter effect, is present. This occurs often in studies on teratogenicity. The coverage of confidence bounds on the additional risk is shown to be sufficient using a small simulation study.     

Taking Care of Later Life: A Matter of Justice?

Correspondence to: Julia Johnson, Senior Lecturer, School of Health and Social Welfare, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK. E-mail: j.s.johnson{at}open.ac.uk Summary This paper reviews current policies and practices regardingthe provision of long-term care for older people. In particularit focuses on three aspects which are central to social workand care management: current developments in residential andnursing home care; charging for care; and the shifting boundarybetween health and social care. It argues that, in all respects,these policies and the ways in which they are being implementedare incompatible with the notion of social justice. Over thelast fifty years, the older generation has invested heavilyin the welfare state and continues to make a significant contributionto it. The security and well-being of those in need of long-termcare is, however, being threatened by the marketization andcommodification of care provision.     

Bathing and the Politics of Care

Though providing baths in the community for disabled and older people has long been an area of service dispute, it has received little academic or policy attention. This is partly because bathing and washing are assumed to be common-sense activities. This paper suggests instead that washing and bathing are far from straightforward or common-sense and that specific meanings attach to them in ways that affect how people experience the receiving of help in these areas. It explores the history of bathing and washing and the significance of touch and nakedness in service provision. It then turns to the service providers who have traditionally undertaken such work—the community nursing and home care services—exploring the rationales that underlie such patterns and the implications of current changes in community care.     

Interactions Among Sexual Activity,Menstrual Cycle Phase,and Immune Function in Healthy Women

Past research has found menstrual-cycle-related changes in functional immune response; we examined if sexual activity also changed markers of immune defense. We followed 32 naturally cycling women (15 sexually active with a partner ≥ 1 time/week, 17 sexually abstinent for the last four months) over one menstrual cycle. Participants provided serum and saliva samples at menses and ovulation, and additional saliva samples at midfollicular and midluteal phases. At each phase, participants also self-reported symptoms associated with colds, flu, pain, menstrual discomfort, and premenstrual syndrome. We tested saliva and serum for ability to kill Escherichia coli or Candida albicans, and serum for complement protein activity. For serum-mediated pathogen killing, among sexually active women only, there was a significant midcycle decrease in killing of E. coli. For saliva-mediated pathogen killing, among abstinent women only, there was a significant midcycle decrease in killing of E. coli, and midcycle increase in killing of C. albicans. Sexually active women had significantly lower complement activity than abstinent women overall. Finally, both groups reported lower physical symptoms at midcycle and higher symptoms at menses. There may be important differences in immune function between healthy women who are sexually active versus abstinent. Further replication is warranted.     

Behind Closed Doors: An Exploration of Kinky Sexual Behaviors in Urban Lesbian and Bisexual Women

This study of 347 urban, self-identified lesbian (n = 289) and bisexual (n = 58) women examined women's engaging in 4 kinky sexual behaviors: bondage/domination, sadomasochism, photo/video exhibitionism, and asphyxiation/breath play. A cross-sectional, brief-intercept survey was administered at 2 New York City gay, lesbian, and bisexual community events. Over 40% reported engaging in at least 1 of these behaviors, and 25% reported engaging in multiple behaviors. Bisexual women were more likely to have engaged in any kinky sexual behavior and photo/video exhibitionism. White women were more likely than women of color to have engaged in bondage/domination. Compared to older women, younger women were more likely to have engaged in photo/video exhibitionism and asphyxiation/breath play. Participants who were younger when they came out to others, and younger at their same-sex sexual debut, were more likely to have engaged in any and each of the behaviors compared to women who were older at those developmental events.     

Demographic Predictors of Consistency and Change in Heterosexuals' Attitudes toward Homosexual Behavior over a Two-Year Period

This study investigated demographic predictors of consistency and change in heterosexual people's attitudes toward homosexual behavior. A nationally representative sample of Australian men and women were recruited via random digit dialling in 2004 through 2005. Participants completed annual computer-assisted telephone interviews over the next five years. Questions about attitudes toward male and female homosexual behavior were assessed at Wave 1 (2004–2005) and Wave 3 (2006–2007) of the study. The majority of the sample reported tolerance of both male and female homosexual behavior (with women slightly more tolerant than men). Multivariate analyses showed that those who regularly attended religious services were more likely to consistently disapprove of homosexual behavior and more likely to change from tolerant to disapproving. Among those who were initially tolerant, younger respondents and those with higher educations were less likely to become homophobic. The results of this study show that individual attitudes toward homosexual behavior are open to change, particularly toward a more tolerant position. Religiosity appears to be consistently associated with the development and reinforcement of homophobic tendencies.     

The curious absence of love stories in women's talk

Sociological debate has dealt with love in a number of different ways. For some, love offers a unique opportunity; it is a path to salvation (Jackson, 1993; Langford, 1999). Others, however, take a more sceptical approach to love in modern society: for Beck and Beck‐Gernsheim (1995) love represents the path to extreme individualization, for Illouz (1997) it is ultimately underpinned by consumerism, and perhaps most extreme, for Bauman (2003) love has been destroyed. Giddens offers a slightly different (and more hopeful) perspective and suggests that with growing choice and freedom, love has become ‘confluent’ and temporary subject to individuals' needs (Giddens, 1992). When adult women were asked about love and how they have experienced love in their own lives, however, few of these themes emerged. Instead many women found it difficult to talk about their feelings generally and love in particular. There was an absence of falling in love stories and rather, women explained that they ‘drifted’ into relationships, or they ‘just happened’. The discourses and languages that these women used to explain love and their relationships will be explored in this paper. Love was simultaneously loudly absent and quietly present.