Sex differences in the development of mild cognitive impairment and probable Alzheimer’s disease as predicted by hippocampal volume or white matter hyperintensities

This study examined biological sex differences in the development of mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) development as predicted by changes in the hippocampus or white matter hyperintensities. A secondary data analysis of the National Alzheimer’s Coordinating Center Uniform Data Set was conducted. We selected samples of participants with normal cognition at baseline who progressed to MCI (n = 483) and those who progressed to probable AD (n = 211) to determine if hippocampal volume or white matter hyperintensities (WMH) at baseline predicted progression to probable AD or MCI and whether the rate of progression differed between men and women. The survival analyses indicated that changes in hippocampal volumes affected the progression to probable AD (HR = 0.535, 95% CI [0.300–0.953]) only among women. White men had an increased rate of progression to AD (HR = 4.396, CI [1.012–19.08]; HR = 4.665, 95% CI [1.072–20.29]) compared to men in other race and ethnic groups. Among women, increases in hippocampal volume ratio led to decreased rates of progressing to MCI (HR = 0.386, 95% CI [0.166–0.901]). Increased WMH among men led to faster progression to MCI (HR = 1.048. 95% CI [1.011–1.086]). Women and men who were older at baseline were more likely to progress to MCI. In addition, results from longitudinal analyses showed that women with a higher CDR global score, older age at baseline, or more disinhibition symptoms experienced higher odds of MCI development. Changes in hippocampal volumes affect the progression to or odds of probable AD (and MCI) more so among women than men, while changes in WMH affected the progression to MCI only among men.     

蒙古尔部族的组织

本文介绍了蒙古尔部族的组成、形成和发展,并对其族长、土司的特点和承继作了详尽的描述。本文介绍了蒙古尔部族的组成、形成和发展,并对其族长、土司的特点和承继作了详尽的描述。     

蒙古尔部族的组织(续二)

本文对蒙古尔部族的组成、形成和发展作了介绍,其中对族长、土司的特点和承继作了详尽的描述。     

Education and Health Conditions Among the Currently Incarcerated and the Non-incarcerated Populations

Population Research and Policy Review - Previous research has found a strong link between educational attainment and health, where the highly educated live longer and healthier lives than those...     

Multidimensional Analysis of Deprivation and Fragility Patterns of Migrants in Lombardy,Using Partially Ordered Sets and Self-Organizing Maps

Social Indicators Research - In this paper, we present a multidimensional fuzzy analysis of the levels and the patterns of poverty and social fragility of migrants’ families, in the Italian...     

The Women’s Empowerment in Livestock Index

Social Indicators Research - The empowerment of women in the livestock sector is fundamental to achieve gender equality. It also is instrumental for increased household productivity and improved...     

Housing and Health in an Aboriginal Community in Bourke,New South Wales

Many aborigines in rural and in urban centres live in housing conditions which prevent them from leading a normal family life. This paper describes how a deficiency in number, type, quality and administration of housing in the rural town of Bourke, New South Wales, contributed to the poor morale of the aborigines as well as being a physical, psychological and social health hazard.     

Making the Randomized Response Technique Work

The ability of the randomized response technique to obtain sensitiveinformation on surveys was compared to two other methods involvingself-administered questionnaires. Using a national probabilitysample, and extending upon a number of developmental changeswhich have evolved over the years, the randomized response techniqueproved to be decidedly superior to the other methods.