Development and application of a dose–response model for Elizabethkingia spp

Elizabethkingia spp. are common environmental pathogens responsible for infections in more vulnerable populations. Although the exposure routes of concern are not well understood, some hospital-associated outbreaks have indicated possible waterborne transmission. In order to facilitate quantitative microbial risk assessment (QMRA) for Elizabethkingia spp., this study fit dose–response models to frog and mice datasets that evaluated intramuscular and intraperitoneal exposure to Elizabethkingia spp. The frog datasets could be pooled, and the exact beta-Poisson model was the best fitting model with optimized parameters α  = 0.52 and β = 86,351. Using the exact beta-Poisson model, the dose of Elizabethkingia miricola resulting in a 50% morbidity response (LD₅₀) was estimated to be approximately 237,000 CFU. The model developed herein was used to estimate the probability of infection for a hospital patient under a modeled exposure scenario involving a contaminated medical device and reported Elizabethkingia spp. concentrations isolated from hospital sinks after an outbreak. The median exposure dose was approximately 3 CFU/insertion event, and the corresponding median risk of infection was 3.4E-05. The median risk estimated in this case study was lower than the 3% attack rate observed in a previous outbreak, however, there are noted gaps pertaining to the possible concentrations of Elizabethkingia spp. in tap water and the most likely exposure routes. This is the first dose–response model developed for Elizabethkingia spp. thus enabling future risk assessments to help determine levels of risk and potential effective risk management strategies.     

Prosody and the Acquisition of Hierarchical Structure in Toddlers and Adults

Though language manifests linearly, one word at a time, children must learn that words are embedded in constituents, which are in turn embedded in larger constituents. That is, they must learn that syntax is hierarchically structured. Prosody—speech melody and rhythm—is likewise hierarchically organized, with smaller prosodic constituents embedded in larger ones. This paper presents results showing that 20‐month‐olds (N = 40) can use modifier + clause prosody to learn constituents at multiple levels in a hierarchically structured artificial grammar, but that they fail to learn from clause + modifier prosody. We consider several explanations for this asymmetry, and suggest that it may be due to the frequency of the two constructions in the input. Two parallel experiments with adults suggest that older learners may not be able to learn the prosodically marked constituents. Instead, adult responses are likely based on perceptually prominent boundary words.     

Association between sarcopenia and erectile dysfunction in males with type II diabetes mellitus

Background: The prevalence rates for both sarcopenia and erectile dysfunction (ED) gradually increase in middle-aged and elderly diabetic male population and they impair physical functioning, sexual functioning, and quality of life. The aim of the present study was to evaluate the sarcopenia in patients with diabetic ED.

Methods: The study included 98 male patients with type II diabetes mellitus (DM) aged 18–80?years. Blood chemistry and hormone levels were obtained. The International Index of Erectile Function (IIEF-5) questionnaire was administered to the patients. The patients were divided into three groups according to the IIEF-5 score; a score of 5–10 points indicated severe ED, a score of 11–20 indicated moderate ED, and a score of 21–25 points indicated no ED. The muscle mass, handgrip strength, timed up and go test, upper mid-arm circumference, calf circumference, and body mass index were obtained. The statistical analysis was performed using MedCalc Statistical Software version 12.7.7. All parameters were compared between the three groups.

Results: Of 98 patients included in the study, 84 patients had severe sarcopenia, 13 had moderate sarcopenia, while only one patient had normal muscle mass. The mean age was 56.59?±?11.46?years. When patients were divided into three groups according to IIEF-5 score, 38 had severe ED, 39 had moderate ED, and 21 had no ED. There was a significant difference between the three groups in terms of handgrip strength, timed up and go test scores, upper mid-arm circumference, and calf circumference (p?Conclusions: Although muscle mass remains unchanged, muscle strength and physical performance decrease in diabetic ED patients. Diabetic patients with severe and moderate ED have lower muscle strength and physical performance.     

Attitudes Toward Women in Health Care Organizations: A Turkish Case Study

Abstract

The aim of this article is to examine the health care employees’ attitudes toward women in health care organizations in Turkey. It was measured using a 25-item scale by Spence, Helmreich, and Stapp (1973 Spence, J. T., Helmreich, R., & Stapp, J. (1973). A short version of the Attitudes toward Women Scale (AWS). Bulletin of the Psychonomic Society, 2(4), 219–220. doi:10.3758/BF03329252[Crossref] , [Google Scholar]). The study was conducted on 541 employees: 279 males and 262 females. Structural equation model (SEM) was applied to analyze the relationship between gender, marital status, and income and attitudes toward woman. The result of this analysis showed that the relations between gender, marital status, and income and attitudes toward woman were statistically significant. All three hypotheses were statistically supported. This result indicated that employees’ marital status and (monthly) income significantly predicted their scores of attitudes toward woman in a positive direction. Besides, employees’ gender significantly predicted their scores of attitudes toward woman in an inverse direction. Future research can focus on investigating the effects of the attitudes toward women on other elements (e.g., performance, motivation, job satisfaction) or a wider sample to reach more generalized results.     

Infants' Ability to Distinguish Between Intentional and Accidental Actions and Its Relation to Internal State Language

The experiment reported here investigated infants' concept of intention, as well as the relation among intention understanding, general productive vocabulary, and internal state language production during the 2nd year. Results from an imitation task indicated that 18‐month‐olds are better able to differentiate between intentional and accidental actions than 14‐month‐olds. Although there was no relation between infants' performance on the intention task and their general productive vocabulary, internal state language production at 30 months was predicted by infants' ability to differentiate between intentional and accidental actions about a year earlier. These findings shed light on the developmental progression of infants' concept of intention, as well as on the continuity between infants' understanding of intentional action and their ability to use internal state words.     

Multimodal hub location and hub network design

Through observations from real life hub networks, we introduce the multimodal hub location and hub network design problem. We approach the hub location problem from a network design perspective. In addition to the location and allocation decisions, we also study the decision on how the hub networks with different possible transportation modes must be designed. In this multimodal hub location and hub network design problem, we jointly consider transportation costs and travel times, which are studied separately in most hub location problems presented in the literature. We allow different transportation modes between hubs and different types of service time promises between origin–destination pairs while designing the hub network in the multimodal problem. We first propose a linear mixed integer programming model for this problem and then derive variants of the problem that might arise in certain applications. The models are enhanced via a set of effective valid inequalities and an efficient heuristic is developed. Computational analyses are presented on the various instances from the Turkish network and CAB data set.     

Braving Human Suffering: Death Education and its Relationship to Empathy and Mindfulness

Social workers are likely to encounter clients dealing with traumatic grief and death in their practice. Though death education has gained in popularity and acceptance, few social work students receive coursework in this area and many are unprepared to deal with their clients' and their own emotions regarding death and grief. Though death-related content may evoke provider avoidance, mindfulness and empathy may help regulate provider emotions and responses. This United States-based study evaluates the effectiveness of experiential death education on mindfulness and empathy. Measures in three separate cohorts were given at the beginning and end of the course. Results show statistically significant increases on the Five Facet Mindfulness Questionnaire and the Questionnaire of Cognitive and Affective Empathy, indicating that such a course may be effective in increasing both mindfulness and empathy in social work students and those in related fields.